Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model ....Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model of phylogenetic branching,
analyses of nucleic acid structure and content (spin chain models of
RNA binding and of DNA open reading frames), and insights into the
origin of the code itself (via numerical codon similarity measures).
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Markov invariants and phylogenetic tree reconstruction. The project will assist Australia to progress as an innovator in the production phylogenetic tree reconstruction techniques.
Identifying species is a difficult task with environmental, social and economic benefits to Australia. DNA evidence and phylogenetic methods clearly achieve this task. Conservation of rare species depends upon identification and hence robust phylogenetic analysis. Phylogenetically identifying fish species has econom ....Markov invariants and phylogenetic tree reconstruction. The project will assist Australia to progress as an innovator in the production phylogenetic tree reconstruction techniques.
Identifying species is a difficult task with environmental, social and economic benefits to Australia. DNA evidence and phylogenetic methods clearly achieve this task. Conservation of rare species depends upon identification and hence robust phylogenetic analysis. Phylogenetically identifying fish species has economic importance as different fish species are all managed separately, having different catch limits, catch areas and market values. Using effective phylogenetic methods, epidemiologists can track the spread of a disease through a population. Read moreRead less
Binuclear palladium motifs in synthetic transformations. Reactions involving palladium compounds with organic reagents are important for synthesis of new materials, pharmaceuticals, and molecules of value in medical research. This project will provide a better understanding of applications of palladium in these fields, and structural features of compounds containing chemical bonds linking metal atoms.
Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in sit ....Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in situ. This will enable the control of stereochemistry in photoredox reactions – not possible with standard catalysts - and establish other useful synthetic transformations. These strategies will make it easier to prepare valuable classes of organic molecules – efficiently, safely, and cost-effectively.
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Outflows, Jets and Plumes. This project studies how fluid flows out from a small concentrated object into a second surrounding fluid. New solution methods will be provided, and new results about how these fluid flows evolve will be obtained. These are important problems with significance in modelling underwater explosions. They are also important in astrophysics, and will help explain the shapes of outflows from some stars or galaxies. The outcomes of the project will be a deeper mathematical un ....Outflows, Jets and Plumes. This project studies how fluid flows out from a small concentrated object into a second surrounding fluid. New solution methods will be provided, and new results about how these fluid flows evolve will be obtained. These are important problems with significance in modelling underwater explosions. They are also important in astrophysics, and will help explain the shapes of outflows from some stars or galaxies. The outcomes of the project will be a deeper mathematical understanding of which outflow shapes are stable, and under what circumstances they might become unstable. This will provide valuable information about galaxy shapes, and a new suite of computational methods for solving such problems.Read moreRead less
Study of molecular interactions between wood pitch fixatives and components of wood pitch. Wood resins, released in pulping, agglomerate in the papermaking process to cause pitch deposits. These deposits adversely affect paper machine efficiency and product quality and limit further recycling of process water. This project aims to investigate the interactions between the components of the wood resins and different fixatives using capillary electrophoresis and other techniques. This knowledge w ....Study of molecular interactions between wood pitch fixatives and components of wood pitch. Wood resins, released in pulping, agglomerate in the papermaking process to cause pitch deposits. These deposits adversely affect paper machine efficiency and product quality and limit further recycling of process water. This project aims to investigate the interactions between the components of the wood resins and different fixatives using capillary electrophoresis and other techniques. This knowledge will provide a better understanding of the role of the physical and chemical properties of the fixatives in fixing the different compounds in wood resins. Molecular modelling will be used to design new fixatives that will be selective to a mixture of wood resins.
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Reduced water usage in the Australian pulp and paper industry through novel process chemistry. Norske Skog Paper Mill operates two paper mills on major rivers in Australia. For these mills to reduce water consumption greater recycling of the process water is needed which results in a build-up of detrimental substances that will affect paper machine performance and efficiency. The knowledge gained from this project will help the paper mills to find strategies to control the build-up of the detr ....Reduced water usage in the Australian pulp and paper industry through novel process chemistry. Norske Skog Paper Mill operates two paper mills on major rivers in Australia. For these mills to reduce water consumption greater recycling of the process water is needed which results in a build-up of detrimental substances that will affect paper machine performance and efficiency. The knowledge gained from this project will help the paper mills to find strategies to control the build-up of the detrimental material and deal with it in such a way that the process water can be recycled and the paper mills can reduce water consumption.Read moreRead less
Mathematical and computational analysis of ship wakes. This project aims to develop mathematical and computational tools to compute the energy in a given ship wake and to determine a range of properties of a ship by taking simple measurements of the water height as the ship travels past. The expected outcomes of this project include a suite of algorithms that back-calculate the hull shape and operating conditions of a moving ship given only the surface height data measured at a single point. The ....Mathematical and computational analysis of ship wakes. This project aims to develop mathematical and computational tools to compute the energy in a given ship wake and to determine a range of properties of a ship by taking simple measurements of the water height as the ship travels past. The expected outcomes of this project include a suite of algorithms that back-calculate the hull shape and operating conditions of a moving ship given only the surface height data measured at a single point. These results should have direct implications for measuring damage to coastal zones by ship wakes and for surveillance of shipping channels.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
Transient Astronomical Sources at Radio Frequencies. Australian radio telescopes are among the finest and most modern anywhere in the world, and they are the only such instruments that can study the Southern Hemisphere sky. The University of Tasmania operates two radio observatories, at Hobart, Tas, and Ceduna, SA, that are used together to detect astronomical pulses arriving simultaneously at the two sites. The techniques of interference suppression, dispersion searching, fast sampling over b ....Transient Astronomical Sources at Radio Frequencies. Australian radio telescopes are among the finest and most modern anywhere in the world, and they are the only such instruments that can study the Southern Hemisphere sky. The University of Tasmania operates two radio observatories, at Hobart, Tas, and Ceduna, SA, that are used together to detect astronomical pulses arriving simultaneously at the two sites. The techniques of interference suppression, dispersion searching, fast sampling over broad bandwidths, and high speed data transmission between Ceduna and Hobart that will be implemented in this project have direct applications in science and the communications industry. The students who will develop this equipment will carry over their expertise to the private sector.Read moreRead less