Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
New tools to detect ecological effects of contaminants in estuaries. Identifying risks to estuarine environments from pollutants is difficult for environmental managers, who must choose between laboratory toxicity testing that is precise, but hard to generalise to field situations, and more realistic field-based monitoring, which is expensive, with a high signal to noise ratio. New molecular techniques may provide more options. Metabolomics can provide insights into the health of animals, and ec ....New tools to detect ecological effects of contaminants in estuaries. Identifying risks to estuarine environments from pollutants is difficult for environmental managers, who must choose between laboratory toxicity testing that is precise, but hard to generalise to field situations, and more realistic field-based monitoring, which is expensive, with a high signal to noise ratio. New molecular techniques may provide more options. Metabolomics can provide insights into the health of animals, and ecogenomics offers a way to rapidly assess the composition of an ecological community. These techniques offer great promise, but they must be cross-validated against existing methods to derive the best ’toolbox’. Working with Melbourne Water and CSIRO the investigators aim to do this using demonstration estuaries in Victoria.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100155
Funder
Australian Research Council
Funding Amount
$648,000.00
Summary
NanoMin; Quantitative Mineral Mapping of Nanoscale Processes. NanoMin: quantitative mineral mapping of nanoscale processes:
The project seeks to establish an electron microscope-based mineral mapping and analysis facility to provide rapid, quantitative and statistically reliable mineralogical, petrographic and metallurgical data unobtainable by other means in fine-grained materials. The proposed equipment can identify minerals in complex mixtures of sub-µm-grain size materials by virtue of an i ....NanoMin; Quantitative Mineral Mapping of Nanoscale Processes. NanoMin: quantitative mineral mapping of nanoscale processes:
The project seeks to establish an electron microscope-based mineral mapping and analysis facility to provide rapid, quantitative and statistically reliable mineralogical, petrographic and metallurgical data unobtainable by other means in fine-grained materials. The proposed equipment can identify minerals in complex mixtures of sub-µm-grain size materials by virtue of an integrated software and hardware system called NanoMin which incorporates a spectral deconvolution engine combined with a mineral spectra database. A key limitation in understanding complex materials is sub-micron to nanometer scale spatial variability of mineralogical phases. Imaging and quantifying these phases is now possible with the NanoMin system. This promises to open up petrological, geobiological, and materials science research in complex fine-grained materials.Read moreRead less
Modern statistical methods for clustering community ecology data. This project will develop statistical methods and software for clustering community ecology data, and use them to analyse systematic survey and citizen science program data collected along the Great Barrier Reef. By doing so, the project will address the dearth of statistical classification techniques for high-dimensional, multi-response data with complex relationships. When the resultant clustering methods are used to construct b ....Modern statistical methods for clustering community ecology data. This project will develop statistical methods and software for clustering community ecology data, and use them to analyse systematic survey and citizen science program data collected along the Great Barrier Reef. By doing so, the project will address the dearth of statistical classification techniques for high-dimensional, multi-response data with complex relationships. When the resultant clustering methods are used to construct bioregions and characterise species’ environmental responses, they should significantly enhance evaluations of the impact of human activity and environmental change on coral diversity. Ultimately, these evaluations can underpin future decisions in the conservation and management of the Great Barrier Reef.Read moreRead less
Mechanisms Of Glucocorticoid Resistance In Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.
Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less