Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Advancing vegetation classification and mapping to meet conservation needs. The project aims to develop advanced statistical and modelling techniques to classify and map vegetation over very large areas, using the most extensive and detailed vegetation data set in Australia and new methods to evaluate these classifications. Such classifications and maps provide the data needed to make biodiversity conservation decisions, yet current operational methods are limited over very large areas, and cann ....Advancing vegetation classification and mapping to meet conservation needs. The project aims to develop advanced statistical and modelling techniques to classify and map vegetation over very large areas, using the most extensive and detailed vegetation data set in Australia and new methods to evaluate these classifications. Such classifications and maps provide the data needed to make biodiversity conservation decisions, yet current operational methods are limited over very large areas, and cannot deal with varied sources of uncertainty. Expected outcomes and benefits include a fine-scale vegetation classification and map for almost a million square kilometres, and associated analytical tools and guidelines for large-scale vegetation classification and global mapping.Read moreRead less
Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, ....Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, unprecedented in scope and resolution. Outcomes include an open access database to quantify and visualise intra-urban air pollution and human exposure and develop air quality maps and smoke pollution management tools. It is expected to advance the evidence-based management of air as a resource, increasing economic prosperity and enhancing human health and quality of life.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian po ....Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian population. Accurate and objective per-capita based consumption and release estimates for a wide range of chemicals is intended to provide a baseline against which to measure changes in our chemosphere.Read moreRead less
Saving Nemo: Reducing animal use in toxicity assessments of wastewater. Every day, Australians produce ~5 billion litres of wastewater, which contains a cocktail of chemicals. Industries that discharge wastewater are required to assess chemical risks to the receiving environments by conducting whole animal direct toxicity assessments (DTA), which are expensive and pose an ethical dilemma. Our preliminary research shows that new in vitro bioassays provide an ethical and cost effective alternative ....Saving Nemo: Reducing animal use in toxicity assessments of wastewater. Every day, Australians produce ~5 billion litres of wastewater, which contains a cocktail of chemicals. Industries that discharge wastewater are required to assess chemical risks to the receiving environments by conducting whole animal direct toxicity assessments (DTA), which are expensive and pose an ethical dilemma. Our preliminary research shows that new in vitro bioassays provide an ethical and cost effective alternative that could be incorporated into DTA programs if their ecological relevance can be demonstrated. This project will develop and validate a new and internationally significant suite of in vitro bioassays for incorporation into DTA programs, leading to more ethical, cost effective and improved environmental protection.Read moreRead less
Unravelling how aquatic coastal networks regulate nitrogen removal . The aim of this project is to determine the nitrogen removal pathways of the coastal zone using a number of innovative field and modelling approaches. Little is known about how the complex coastal landscape controls trade-offs that maximise nitrogen removal but minimise nitrous oxide (a potent greenhouse gas) emissions. The outcomes of this study will significantly advance our understanding of the coastal zone in regional and g ....Unravelling how aquatic coastal networks regulate nitrogen removal . The aim of this project is to determine the nitrogen removal pathways of the coastal zone using a number of innovative field and modelling approaches. Little is known about how the complex coastal landscape controls trade-offs that maximise nitrogen removal but minimise nitrous oxide (a potent greenhouse gas) emissions. The outcomes of this study will significantly advance our understanding of the coastal zone in regional and global nitrogen budgets. This will provide significant benefits such as a new science-based quantitative framework to facilitate best practice management to reduce terrestrial nitrogen loads and associated downstream impacts such as eutrophication, and reduce nitrous oxide emissions and associated global warming.
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New metrics to measure and track fauna community condition in Australia. This project aims to improve how biodiversity is measured by developing a system to describe the condition of animal communities, analogous to those used for plant communities. It develops and tests the system for Australia’s birds, then extends the approach to other animal groups. The project expects to develop a data-driven typology of bird communities, accompanying community condition metrics that are scalable from site ....New metrics to measure and track fauna community condition in Australia. This project aims to improve how biodiversity is measured by developing a system to describe the condition of animal communities, analogous to those used for plant communities. It develops and tests the system for Australia’s birds, then extends the approach to other animal groups. The project expects to develop a data-driven typology of bird communities, accompanying community condition metrics that are scalable from site to national levels, and guidance for using these metrics in practice. These metrics will enable holistic and relevant measures of the biodiversity value of sites, improve evaluation of restoration actions, reveal trends in community condition, and inform monitoring and evaluation tools for emerging biodiversity markets.Read moreRead less
Re-EValuating The Inhibition Of Stress Erosions (REVISE): Gastrointestinal Bleeding Prophylaxis In ICU
Funder
National Health and Medical Research Council
Funding Amount
$2,955,164.00
Summary
Around 50,000 patients in Australian Intensive Care Units receive a drug called pantoprazole each year with the aim of preventing bleeding from the gut. Recent research suggests this practice is ineffective and may harm patients by increasing their risk of serious infections. We will perform a definitive study to determine whether the widespread use of pantoprazole is beneficial or harmful.