Growth Regulatory Transcriptional Networks And Novel Therapies In Vascular Pathobiology
Funder
National Health and Medical Research Council
Funding Amount
$576,760.00
Summary
Cardiovascular disease and cancer together account for the majority of all deaths. Underpinning both these conditions are cellular and molecular changes in our blood vessels. This Fellowship will enable Professor Khachigian to enhance our understanding of fundamental mechanisms regulating the pathogenesis of vascular disease, and by harnessing this new knowledge in preclinical and human trials, generate novel strategies to combat a range of diseases through strategic partnership, collaboration a ....Cardiovascular disease and cancer together account for the majority of all deaths. Underpinning both these conditions are cellular and molecular changes in our blood vessels. This Fellowship will enable Professor Khachigian to enhance our understanding of fundamental mechanisms regulating the pathogenesis of vascular disease, and by harnessing this new knowledge in preclinical and human trials, generate novel strategies to combat a range of diseases through strategic partnership, collaboration and training.Read moreRead less
Assessing The Capacity For Sustainable Finfish Aquaculture In The Vicinity Of Seagrasses
Funder
Fisheries Research and Development Corporation
Funding Amount
$478,825.00
Summary
Globally, aquaculture accounts for over 50% of fish production. However, if poorly planned, rapid expansion to meet the ever increasing demand for seafood brings with it an environmental risk associated with eutrophication and organic enrichment of the seabed, adversely affecting marine coastal ecosystems. Approximately 75-85% of the nitrogen discharged from finfish aquaculture is dissolved and dispersed to nearby habitats. A major spatial constraint on aquaculture in nearshore areas around much ....Globally, aquaculture accounts for over 50% of fish production. However, if poorly planned, rapid expansion to meet the ever increasing demand for seafood brings with it an environmental risk associated with eutrophication and organic enrichment of the seabed, adversely affecting marine coastal ecosystems. Approximately 75-85% of the nitrogen discharged from finfish aquaculture is dissolved and dispersed to nearby habitats. A major spatial constraint on aquaculture in nearshore areas around much of Australia is the potential for these dispersed nutrients to negatively affect seagrasses. Seagrasses can be sensitive to increases in nitrogen, which can lead to habitat loss. This loss can have significant environmental and economic impacts with potential losses of ecosystem services including decreases in commercial and recreational fisheries catches, increases in sand instability and erosion, reduced biodiversity, loss of nitrogen assimilation and cycling, and loss of carbon sequestration.
In other situations, small increases in nutrients may have a positive effect on seagrasses, and thus it is not clear what the consequences of aquaculture derived nutrients will be. Subsequently, we can’t robustly determine the level of finfish aquaculture that can be sustainably supported by seagrass ecosystems. There is therefore a need to develop a process to determine the likelihood of seagrass growth (or loss) due to aquaculture derived nutrient inputs. This work will develop metrics that can be used in other aquaculture developments and in long-term regional monitoring.
Clean Seas Seafood Pty Ltd are developing a new lease for the sea-cage aquaculture of 4500 tonnes of yellowtail kingfish (YTK) in the Fitzgerald Bay region. The nearshore habitats throughout the region are dominated by long-lived Posidonia seagrass. While Fitzgerald Bay was the original focus of YTK aquaculture in SA, it has not been utilised for ~10 years, essentially giving us the potential to study this system prior to the commencement of aquaculture (currently planned for ~ July 2019), as well as while production is increasing, and it thus provides an ideal case study for assessing how to sustainably farm finfish in a seagrass dominated ecosystem.
Objectives: 1. Determine cost-effective approaches to assessing the influence of finfish aquaculture derived nutrients on seagrasses, and using Fitzgerald Bay as a case study, what that influence is. 2. Develop a predictive modelling ability to estimate carrying capacity and allow scenario analysis of future aquaculture development and how it might affect seagrasses, to allow managers to make informed decisions about where to place future developments, and how much to allow existing developments to expand. 3. Use Fitzgerald Bay as a case study to document seagrass condition using a range of metrics both before the commencement of finfish aquaculture, and once production has reached a substantial level. 4. Develop a range of cost-effective indicators for monitoring the effects of aquaculture on adjacent seagrass beds. Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100441
Funder
Australian Research Council
Funding Amount
$474,443.00
Summary
Sounds of change: using ecological knowledge to advance acoustic monitoring. To recover biodiversity, conservation actions must be informed by robust ecological data. In partnership with Bush Heritage Australia, this project aims to transform ecological monitoring with eco-acoustic technologies by developing new acoustic metrics to measure biodiversity at various levels, from individual species through to whole communities. This project will combine advanced computer methods with theories of ani ....Sounds of change: using ecological knowledge to advance acoustic monitoring. To recover biodiversity, conservation actions must be informed by robust ecological data. In partnership with Bush Heritage Australia, this project aims to transform ecological monitoring with eco-acoustic technologies by developing new acoustic metrics to measure biodiversity at various levels, from individual species through to whole communities. This project will combine advanced computer methods with theories of animal sounds and communities to generate metrics that are informed by animal ecology and directly address monitoring needs of conservation organisations. By experimentally testing the metrics on long-duration real-world sound data, this project will provide new tools to measure conservation impact and prioritise actions.Read moreRead less
Integrating Recreational Fishing Information Into Harvest Strategies For Multi-sector Fisheries
Funder
Fisheries Research and Development Corporation
Funding Amount
$444,676.00
Summary
Integration of recreational fishing (RF) into harvest strategies (HS) is necessary for many fisheries in Australia, to account for catches that can equal or exceed commercial catch for some key species and to address biological and experiential objectives of the RF sector. Both the Productivity Commission’s report Marine Fisheries and Aquaculture (2016) and the ICES Report from the Working Group Recreational Fishing Surveys (2018) recommend formal integration of RF into stock assessments and har ....Integration of recreational fishing (RF) into harvest strategies (HS) is necessary for many fisheries in Australia, to account for catches that can equal or exceed commercial catch for some key species and to address biological and experiential objectives of the RF sector. Both the Productivity Commission’s report Marine Fisheries and Aquaculture (2016) and the ICES Report from the Working Group Recreational Fishing Surveys (2018) recommend formal integration of RF into stock assessments and harvest strategies. Failure to do so puts sustainable management goals and legislated state and Commonwealth fisheries requirements at risk.
Equitable and quantitative inclusion of RF in harvest strategies is rare. This stems from a traditional focus on the commercial sector and budgetary challenges involved with representatively sampling RF. It is therefore unclear: 1) what types of RF data and monitoring best service stock assessments, (2) which data also track indicators of recreational objectives (often related to the fishing experience), and (3) how to integrate harvest strategy components for multiple sectors. The need to address these knowledge gaps was highlighted by the FRDC priority research call in 2018 - “Integrating recreational fishery data into harvest strategies for multi-sector fisheries in New South Wales”. NSW provides an important test case for addressing issues around RF integration that are faced by most jurisdictions.
Harvest strategy development for multi-sector fisheries requires a transparent and defensible process due to complexities in addressing diverse objectives and apprehension among stakeholder groups. Structured workshops that use easily-understandable, interactive decision support tools and involve independent experts and stakeholder representatives are likely to provide best outcomes. ‘FishPath’ is a leading harvest strategy decision support tool and “bottom up” engagement philosophy that allows experts and stakeholders to interactively contribute to harvest strategy development in a transparent workshop setting. However, it requires additional development in recreational and multi-sector contexts.
Objectives: 1. Obtain information on recreational fishing objectives and facilitate improved understanding among recreational fishers of the role of harvest strategies. 2. Identify types of recreational fishing data and monitoring that provide reliable measures of both the biological and experiential performance of fished populations. 3. Interrogate and extend the FishPath decision support software tool to better characterise and integrate recreational fishing information into harvest strategy development for multi-sector fisheries. 4. Develop guidelines and recommendations for the integration of recreational fishing information into harvest strategies for multi-sector fisheries. 5. Develop draft harvest strategies for key multi-sector fisheries using outcomes from Objectives 1-4. Read moreRead less
Identifying Population Connectivity Of Shark Bycatch Species In NT Waters
Funder
Fisheries Research and Development Corporation
Funding Amount
$66,430.00
Summary
This project is needed for three main reasons:
1. It directly addresses a NT RAC priority in the 2019 call for funding applications relating to improving sustainable yield estimates to inform stock assessment programs for undefined target species and protected species in the Offshore Net and Line Fishery. The project will support sustainable fishing practices for important commercial fisheries in the NT and the development of new commercial opportunities within these fisheries: The impa ....This project is needed for three main reasons:
1. It directly addresses a NT RAC priority in the 2019 call for funding applications relating to improving sustainable yield estimates to inform stock assessment programs for undefined target species and protected species in the Offshore Net and Line Fishery. The project will support sustainable fishing practices for important commercial fisheries in the NT and the development of new commercial opportunities within these fisheries: The impacts of fishery activities on these species, either through bycatch or targeted harvest, are difficult to assess in the absence of information on population connectivity and stock structure.
2. The project will develop capacity for fisheries research and monitoring in NT waters. Genetics methods are widely applied to fisheries research and monitoring and training of an early career fisheries scientist in the application and interpretation of genetic data will be a key outcome of this project.
3. The project will provide key information to support the transition of these species from bycatch to a harvested byproduct species, including an evaluation of leading-edge genetic techniques in fisheries assessment and monitoring.
Objectives: 1. To develop population connectivity model for Whitecheek and Milk Shark 2. To develop capacity for research and monitoring of shark species within the Northern Territory 3. To evaluate the utility of genetic techniques in fisheries monitoring Read moreRead less
Novel Nanotechnology Strategies For Drug Co-delivery And Combined Therapies In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$1,512,250.00
Summary
Key challenges for treating brain diseases include effective delivery of drugs into the brain and targeted delivery to pathogenic areas. I have developed two world-first drug delivery systems that address these challenges. This project will expand their loading and brain delivery capability to deliver a broad range of novel multiple therapeutics to target sites in the brain. Human brain disease models will be used for systematic preclinical evaluation of novel delivery systems and therapeutics.
A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to develop a novel silica nanoparticle-based delivery system for long-lasting oral drug delivery. The particles will be engineered with a spiky morphology that will increase adhesion to the gastrointestinal tract enabling sustained drug release for days or even weeks. Longer lasting oral drug formulations would make it much easier for patients to adhere to the treatment schedules required in chronic diseases like HIV and increase the effectiveness of therapy.
Estimating The Biomass Of Fish Stocks Using Novel And Efficient Genetic Techniques
Funder
Fisheries Research and Development Corporation
Funding Amount
$494,794.00
Summary
The effective management of fisheries resources implicitly requires accurate abundance estimates. But, even after more than a century of effort, this prerequisite need remains one of the greatest challenges facing fisheries scientists. Traditional methods of estimating abundance include parametric and empirical approaches that often rely on extensive time-series of size-at-age data (e.g. from otoliths). Acquiring these data can be expensive and therefore restricted to species that are most econo ....The effective management of fisheries resources implicitly requires accurate abundance estimates. But, even after more than a century of effort, this prerequisite need remains one of the greatest challenges facing fisheries scientists. Traditional methods of estimating abundance include parametric and empirical approaches that often rely on extensive time-series of size-at-age data (e.g. from otoliths). Acquiring these data can be expensive and therefore restricted to species that are most economically important or of conservation concern. Due to the cost of independent sampling, indicators of abundance usually involve fishery-dependent data, which have numerous biases that can affect accurately quantifying population trends.
The clear need for accurate and rapid stock assessments is increasingly apparent in the current climate of competing commercial, recreational and conservation interests. Specifically, marine protected areas have been implemented across all NSW coastal bioregions and are a source of political and public contention as a result of perceived inequalities in access to (and allocation of) fisheries resources, particularly among species shared by commercial and recreational fishers. Also, recent fish kills in NSW due to hypoxic water have sparked debate over the cause of poor water quality and longer-term effects on freshwater habitats. Rapidly quantifying existing and/or changing stock abundances of key species will be essential to inform recovery actions, and advise on the sustainable exploitation of commercial and recreational species. Sampling eDNA could meet these needs by directly facilitating cost-effective biomass and/or relative abundance estimates for population assessments in NSW where fishery-dependent data are scarce or unavailable.
Objectives: 1. Assess the species-specific precision and importance of key influencing abiotic and biotic factors for determining abundances of mulloway and Murry cod using eDNA under controlled conditions. 2. Compare the utility of eDNA against directed fishery-dependant methods for assessing relative abundances of mulloway and Murray cod across appropriate spatio-temporal scales in the wild. 3. Based on results of phase 2, determine what additional factors affect concentration of eDNA such as depth of eDNA water sampling. 4. Assess if eDNA of other selected species collected from samples obtained during 2 above, correspond to routinely collected catch-and-effort data in New South Wales. Read moreRead less
Quantifying And Reducing The Burden Of New And Emerging Psychoactive Substances In Australia
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
The public health threat posed by emerging drugs of concern (e.g., new psychoactive substances (NPS) and crystalline methamphetamine) requires timely and effective public health interventions. This research program will strengthen estimates of the global NPS health burden, enhance the surveillance of unwitting drug consumption, and develop and evaluate novel harm reduction responses. Findings will inform policy and health service delivery, both globally and within Australia.
Systems-based Study, Intervention, Diagnosis And Control Of Gastrointestinal Parasites
Funder
National Health and Medical Research Council
Funding Amount
$2,538,220.00
Summary
Gastrointestinal parasites cause billions of infections and hundreds of thousand of deaths globally each year. Even in developed countries, these parasites remain an important public health risk, through the cost of their control, the acute impacts of infection and their contribution to post-infectious irritable bowel syndrome and chronic fatigue. My team employs cutting-edge methods to improve their diagnosis, surveillance, treatment and control.