Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.
Identifying Target Genes For Novel Anti-epileptic Therapies In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$469,802.00
Summary
Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not respo ....Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not responding to current therapy. This project is designed to identify new biologic pathways which may be interrupted with drugs to prevent seizures in people with epilepsy. This project uses a procedure to induce mutations into genes in mice and then screens for mice which do not seize when challenged with a drug which generates seizures in mice. Genetic studies will identify the mutated genes and these will be used as potential targets for new therapies or will identify new biological pathway which should expand the use of future anti-epileptic drugs.Read moreRead less
Targeting RCAN1 To Treat Type 2 Diabetes And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$814,468.00
Summary
Obesity and impaired insulin secretion are significant contributors to Type 2 diabetes. In this project we demonstrate that a protein called RCAN1 contributes to both fat mass and insulin secretion and that this contribution is exacerbated in obesity and in Type 2 diabetes. We will identify how RCAN1 controls these major metabolic pathways with outcomes including the development of new therapeutics for obesity and Type 2 diabetes.
Topical peptide delivery for cosmetic and therapeutic benefits. Milk is a major Australian agricultural commodity and is now used in a number of topical products for the management of various skin conditions including chafing in babies, eczema and ageing skin. Hence, this work hopes to contribute to promoting and maintaining good health of Australians.
In addition, there is considerable research being conducted on peptide development for a range of diseases and there may be a possibility of ....Topical peptide delivery for cosmetic and therapeutic benefits. Milk is a major Australian agricultural commodity and is now used in a number of topical products for the management of various skin conditions including chafing in babies, eczema and ageing skin. Hence, this work hopes to contribute to promoting and maintaining good health of Australians.
In addition, there is considerable research being conducted on peptide development for a range of diseases and there may be a possibility of delivering these by the skin.
This work, in seeking to understand some of the fundamental determinants governing how exogenously applied peptides distribute in the skin, is also contributing to the development of Australian pharmaceutical and cosmetic industries.Read moreRead less
Effective and efficient corporate tax enforcement. This project uses economic theory and experimental tests in order to inform tax authorities on how to best audit tax receipts from corporations. The project will result in advice on how audit resources should be allocated across firms, if minimising corporate tax evasion and at the same time maximising social welfare are the authority's objective.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100079
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered o ....A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered ocean where waves and ice interact, causing ice-breaking and wave attenuation. This unique facility will enable experiments in sea-ice-wave interactions in a controlled environment. Water and air temperature, thermal stratification, water waveform and ice properties will be adjusted in order to preserve key characteristics of the complex ocean environment.Read moreRead less
Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits a ....Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits also include the development of new cutting-edge methodologies for the investigation of Australian desert landscapes, comprehensive baseline data of how this region has evolved prior to European colonization and resolving why no Pleistocene aged archaeological sites have been found in the region.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100220
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Sonic drilling to provide contamination-free core sampling of rock and unconsolidated sediment. Australia is the world's driest inhabited continent. Understanding environmental and climatic changes, from the temperate period when humans arrived about 50,000 years ago to the present state of widespread aridity, is crucial for modelling future climate change. This facility will provide new generation drilling equipment which is necessary to obtain accurate records.
Palaeoclimate reconstructions from the isotopic signatures of fossilised leaf waxes. This project develops a method for using the chemical signature of fossilised leaf waxes to reconstruct hydrologic change in south-eastern Australia during the Holocene (last 10,000 years) and Eocene (56-34 million years ago). Understanding climate in the geologic past is essential for testing models and projecting future climate with rising carbon dioxide.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100028
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes ....Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes include understanding past global environmental change on multiple time scales, the deep biosphere, plate tectonics, formation and distribution of resources, and generation of hazards. These outcomes are paramount to Australia’s national science and research priorities, and societal and economic prosperity.Read moreRead less