Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Heparin Induced Thrombocytopenia (HIT): Further Characterization Of Disease Mechanism Will Improve Patient Treatment
Funder
National Health and Medical Research Council
Funding Amount
$456,484.00
Summary
Thrombus formation occurs as a side effect of heparin treatment in many patients. This condition is called Heparin Induced Thrombocytopenia (HIT). The clots may be stabilised by secretions from cells called neutrophils. In this project we will study this possibility using a mouse model of HIT and will explore therapeutic approaches to inhibit clot stabilisation.
Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anti ....Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anticancer drugs. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project.Read moreRead less
Signalling Networks As Targets For Antibody Therapy In Glioma.
Funder
National Health and Medical Research Council
Funding Amount
$526,683.00
Summary
Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. It is also possible to generate antibodies that bind to receptors on the surface of can ....Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. It is also possible to generate antibodies that bind to receptors on the surface of cancer cells and block their function. If you target a receptor critical to the growth or survival of a cancer cell in this way, then swtiching-off this signal may inhibit tumor growth. In this proposal we plan to test a panel antibodies that recognize receptors important to the growth of brain cancer. Two of these antibodies have been generated and the other two will be made as part of this proposal. A key aspect of this proposal will be testing these antibodies in combination to determine how many receptors need to be targeted in order to get complete tumor regressions in animal models. Overall this work will help us identify new therapeutic strategies for the treatment of brain cancer. Finally, we will also analyze the way different receptors interact together in brain cancer cells.Read moreRead less
Quantifying the impact of infiltration on dune erosion under waves & surge. Through a series of controlled laboratory experiments and numerical model development, this project aims to determine and quantify for the first time the role of water infiltration on sandy soil stability at actively eroding coastal sand dunes. This project expects to generate much-needed understanding of fundamental dune erosion processes using innovative instrumentation to obtain continuous measurements of wave-dune in ....Quantifying the impact of infiltration on dune erosion under waves & surge. Through a series of controlled laboratory experiments and numerical model development, this project aims to determine and quantify for the first time the role of water infiltration on sandy soil stability at actively eroding coastal sand dunes. This project expects to generate much-needed understanding of fundamental dune erosion processes using innovative instrumentation to obtain continuous measurements of wave-dune interactions, dune profile evolution, and water infiltration. Expected outcomes of this project include improved coastal engineering models to predict dune erosion under waves and increasing water levels. This should provide significant benefit to the future management of coastal assets using nature-based solutions.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
A Robotic System for Steel Bridge Maintenance. This research will bring enormous benefits to Australian community by significantly reducing the environmental impact of civil infrastructure maintenance operations, and improving the working conditions of maintenance workers by minimising their exposure to dust containing hazardous materials. Bridges are a key link that supports rural communities. Besides the 426 steel road bridges in NSW, many hundreds steel road/rail bridges and other steel infra ....A Robotic System for Steel Bridge Maintenance. This research will bring enormous benefits to Australian community by significantly reducing the environmental impact of civil infrastructure maintenance operations, and improving the working conditions of maintenance workers by minimising their exposure to dust containing hazardous materials. Bridges are a key link that supports rural communities. Besides the 426 steel road bridges in NSW, many hundreds steel road/rail bridges and other steel infrastructure in Australia need regular paint stripping and repainting. Australia will gain significant economic and health benefits from commercialising the advanced technologies developed by this project, and become a world leader in developing autonomous systems for infrastructure maintenance.Read moreRead less
Infrastructure project delivery: a life cycle evaluation model for public private partnerships. Governments continue to embrace public-private partnerships so as to obtain value for money and provide financial accountability to taxpayers. This project will determine the most appropriate way to engage the private sector in infrastructure delivery and develop a dynamic life cycle evaluation model to ensure projects are delivered effectively and efficiently.
Real-time analysis of tumour-infiltrating T cells using novel analytical tools. By dynamic visualization of immune cells within intact tumours, we have shown that active screening for target cells optimises their anti-tumour effect. This project will develop novel mathematical/analytical tools to unravel the basic strategies that enable immune cells to position themselves at the right location at the right time.