Immuno-polymeric Drugs For Prostate Cancer Therapy
Funder
National Health and Medical Research Council
Funding Amount
$626,995.00
Summary
Prostate cancer is the most common cancer in men over 50 and the second most frequent cause of cancer deaths in Western society. Docetaxel is the first line of chemotherapy when other intervention strategies are unsuccessful, but 30% of patients suffer from severe side-effects. To address this problem, we will utilise carriers for docetaxel that directly target prostate tumours using a novel antibody approach. This increases accumulation at the tumour site while decreasing off-target toxicity.
Characterisation Of Two Novel Markers Of Osteosarcoma Metastasis As Potential Therapeutic Targets
Funder
National Health and Medical Research Council
Funding Amount
$624,500.00
Summary
Osteosarcoma (OS) is the most common bone tumour in children and adolescents. In spite of aggressive chemotherapy, OS tumours that metastasise to the lungs result in dismal long-term survivals of only 10-20%. For these patients, new treatment options are desperately needed. In this proposal we show compelling data identifying two new markers of OS metastasis. This research aims to validate the suitability of these novel markers as therapeutic targets to prevent OS metastasis.
Development Of A Novel Drug For Chronic And Infected Wounds
Funder
National Health and Medical Research Council
Funding Amount
$482,362.00
Summary
Chronic wounds affect more than 9 million people worldwide and demand for wound care is increasing. The annual cost to healthcare systems in the US and Australia in treating such wounds is US$25 billion and AU$3 billion, respectively, and there is urgent need for more effective approaches.
An optimally integrated treatment process for food waste and wastewater to maximise sustainability in a decentralised treatment plant. Decentralised small scale treatment plants are required for remote communities, resort locations and 'rural residential' developments. This project has access to an operational plant in urban Brisbane serving 21 houses, the first development in urban Australia with full approval for an onsite treatment facility. The plant has been designed to treat an integrate ....An optimally integrated treatment process for food waste and wastewater to maximise sustainability in a decentralised treatment plant. Decentralised small scale treatment plants are required for remote communities, resort locations and 'rural residential' developments. This project has access to an operational plant in urban Brisbane serving 21 houses, the first development in urban Australia with full approval for an onsite treatment facility. The plant has been designed to treat an integrated kitchen waste and blackwater stream, with upstream anaerobic digestion that reduces the survival of wastewater pathogens and generates soluble organic carbon for the biological removal of nitrogen and phosphorous. The project will produce expertise in decentralised treatment systems, including the development of two PhD students in this area.Read moreRead less
Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to ....Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to improve radiotherapy treatments in patients with small lesions with sizes of up to a few centimetres. This will lead to an improved outcome for some cancer patients.Read moreRead less
Infrastructure project delivery: a life cycle evaluation model for public private partnerships. Governments continue to embrace public-private partnerships so as to obtain value for money and provide financial accountability to taxpayers. This project will determine the most appropriate way to engage the private sector in infrastructure delivery and develop a dynamic life cycle evaluation model to ensure projects are delivered effectively and efficiently.
Poly(amino acids) as immune stimulators. This project aims to develop nanoparticles built from natural hydrophobic amino acids as an immune stimulatory delivery system for peptide antigens. Currently available immune stimulants (adjuvants) are often toxic and/or are poorly chemically defined fragments of bacteria or toxins and vary from batch-to-batch. New adjuvants are in high demand; especially to facilitate the use of optimal, but weakly immunogenic, peptide antigens. It is expected that the ....Poly(amino acids) as immune stimulators. This project aims to develop nanoparticles built from natural hydrophobic amino acids as an immune stimulatory delivery system for peptide antigens. Currently available immune stimulants (adjuvants) are often toxic and/or are poorly chemically defined fragments of bacteria or toxins and vary from batch-to-batch. New adjuvants are in high demand; especially to facilitate the use of optimal, but weakly immunogenic, peptide antigens. It is expected that the proposed project will develop a novel efficient, safe and notably biodegradable self-adjuvanting delivery system that can be fully customised to match an antigen of choice. This foundational research should provide important advances for commercial immune stimulatory applications.Read moreRead less
Development of therapeutic agents that target carbonic anhydrase enzymes. This research will discover new chemical entities (compounds) that may lead to therapies for the treatment of cancer, glaucoma and malaria. The research underpins a mechanism to add value to our compounds before partnering with industry to transform the discoveries made here to deliverable therapies that could benefit the health of millions, thus offering a potentially high value contribution to the Australian economy. The ....Development of therapeutic agents that target carbonic anhydrase enzymes. This research will discover new chemical entities (compounds) that may lead to therapies for the treatment of cancer, glaucoma and malaria. The research underpins a mechanism to add value to our compounds before partnering with industry to transform the discoveries made here to deliverable therapies that could benefit the health of millions, thus offering a potentially high value contribution to the Australian economy. The experience and commitment of the multi-disciplinary network of researchers offers exceptional training and employment opportunities for tomorrow's scientists in techniques for discovery and characterisation of novel chemicals, and their interaction with disease targets.Read moreRead less
Eventful learning in quality pre-service science teacher education. The study aims to build a theory that explains quality in science teacher education by identifying successful learning-teaching events across programs of university science teacher education. This theory will guide wider application of eventful learning practices at university to enhance the successful entry of new teachers to the profession.
Assessing and enhancing the resilience of Australian beaches to sea level rise. Accurate forecasting of coastal recession due to sea level rise is required for planning and the design of coastal defences, but the existing method is widely disputed. With collaboration with world leading research partners, this study will perform unique laboratory experiments to determine the vulnerability of Australian beaches to sea level rise and to test environmentally sustainable measures to increase their re ....Assessing and enhancing the resilience of Australian beaches to sea level rise. Accurate forecasting of coastal recession due to sea level rise is required for planning and the design of coastal defences, but the existing method is widely disputed. With collaboration with world leading research partners, this study will perform unique laboratory experiments to determine the vulnerability of Australian beaches to sea level rise and to test environmentally sustainable measures to increase their resilience. The research will address longstanding uncertainties and significantly enhance the ability of communities to plan for a changing climate. The project will deliver new data and models of immediate benefit to professional engineers to enable robust engineering decisions which enhance the safety of coastal communities.Read moreRead less