Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Integrated Kids Hubs - Ensuring Equity of Access for Children. The Integrated Kids Hubs - Ensuring Equity of Access for Children project aims to determine if integrated Hubs are effective in increasing access to child and family services for disadvantaged urban and regional families with children aged 3 years and under, thus improving early identification of developmental vulnerability, parental wellbeing and capacity, and addressing unmet psychosocial needs. If these issues are not identified a ....Integrated Kids Hubs - Ensuring Equity of Access for Children. The Integrated Kids Hubs - Ensuring Equity of Access for Children project aims to determine if integrated Hubs are effective in increasing access to child and family services for disadvantaged urban and regional families with children aged 3 years and under, thus improving early identification of developmental vulnerability, parental wellbeing and capacity, and addressing unmet psychosocial needs. If these issues are not identified and addressed early, these children will go on to struggle in school and life. We will use a pragmatic trial design (meaning the research is embedded in our usual practice), determine the social return on investment, and establish what is needed to scale up the Hubs across NSW and Australia.Read moreRead less
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Stewarding thin markets: improving public sector market effectiveness. This project aims to develop methodologies to identify thin markets in the public service sector. Thin markets, where there are a low number of buyers or low number of sellers, are a major risk for governments utilising a personalised approach to service delivery. This project will develop new methodologies for identifying thin markets and determine ways emerging markets can be stewarded to better achieve their aims.
Creating pathways to child wellbeing in disadvantaged communities. This project aims to test, in nine disadvantaged communities, a model for action that blends new human and digital resources to support respectful, data-driven collaborations between schools, families and community agencies.
The project expects to generate new knowledge in the area of translational prevention science about how to influence risk and protective factors for child wellbeing in a cost-efficient manner and at a scale ....Creating pathways to child wellbeing in disadvantaged communities. This project aims to test, in nine disadvantaged communities, a model for action that blends new human and digital resources to support respectful, data-driven collaborations between schools, families and community agencies.
The project expects to generate new knowledge in the area of translational prevention science about how to influence risk and protective factors for child wellbeing in a cost-efficient manner and at a scale within existing service systems. Project benefits should include a methodology for achieving lasting improvements in child wellbeing, behaviour and school success.
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