Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Industrial Transformation Research Hubs - Grant ID: IH120100021
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Pathways to market: transforming food industry futures through improved sensing, provenance and choice. Pathways to market: transforming food industry futures through improved sensing, provenance and choice. This Research Hub aims to transform the Australian food industry by demonstrating how new knowledge on food production and consumption generated through novel sensing technologies and advanced modelling techniques can be implemented in smart applications to power competitiveness, sustainabil ....Pathways to market: transforming food industry futures through improved sensing, provenance and choice. Pathways to market: transforming food industry futures through improved sensing, provenance and choice. This Research Hub aims to transform the Australian food industry by demonstrating how new knowledge on food production and consumption generated through novel sensing technologies and advanced modelling techniques can be implemented in smart applications to power competitiveness, sustainability and innovation in food value chains.Read moreRead less
Transforming charity to reduce persistent poverty. This project aims to produce empirical knowledge to assist charities to reduce persistent poverty in Australia. In Australia people in poverty use charity to subsidise limited incomes and survive on a day-to-day basis. Recently charities are expected to assist in disrupting poverty in addition to poverty relief. However there is limited knowledge about how charities work with people who are poor and how they can change to work better. This proje ....Transforming charity to reduce persistent poverty. This project aims to produce empirical knowledge to assist charities to reduce persistent poverty in Australia. In Australia people in poverty use charity to subsidise limited incomes and survive on a day-to-day basis. Recently charities are expected to assist in disrupting poverty in addition to poverty relief. However there is limited knowledge about how charities work with people who are poor and how they can change to work better. This project expects to provide knowledge that governments, social service providers, and charities can use to transform their work with people in poverty. Read moreRead less
Integrated Kids Hubs - Ensuring Equity of Access for Children. The Integrated Kids Hubs - Ensuring Equity of Access for Children project aims to determine if integrated Hubs are effective in increasing access to child and family services for disadvantaged urban and regional families with children aged 3 years and under, thus improving early identification of developmental vulnerability, parental wellbeing and capacity, and addressing unmet psychosocial needs. If these issues are not identified a ....Integrated Kids Hubs - Ensuring Equity of Access for Children. The Integrated Kids Hubs - Ensuring Equity of Access for Children project aims to determine if integrated Hubs are effective in increasing access to child and family services for disadvantaged urban and regional families with children aged 3 years and under, thus improving early identification of developmental vulnerability, parental wellbeing and capacity, and addressing unmet psychosocial needs. If these issues are not identified and addressed early, these children will go on to struggle in school and life. We will use a pragmatic trial design (meaning the research is embedded in our usual practice), determine the social return on investment, and establish what is needed to scale up the Hubs across NSW and Australia.Read moreRead less
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Transforming Primary Healthcare Service Delivery: A Digital-Human Approach. This project aims to address the urgent need for a transformational shift in thinking and actions in primary healthcare service delivery. Primary care clinics, the front door of Australia's healthcare, are under considerable strain. By using a four-phase mixed methodology design across four Australian states, this project expects to generate a national evidence-based framework which takes a dual approach combining the us ....Transforming Primary Healthcare Service Delivery: A Digital-Human Approach. This project aims to address the urgent need for a transformational shift in thinking and actions in primary healthcare service delivery. Primary care clinics, the front door of Australia's healthcare, are under considerable strain. By using a four-phase mixed methodology design across four Australian states, this project expects to generate a national evidence-based framework which takes a dual approach combining the use of digital technology with humanness. Expected outcomes include the development of an Australian-first evidence-based digital resource kit, including two new tools, and a new co-designed roadmap to better facilitate this important change journey to enhance patient experience, employee wellbeing and clinic performance.
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ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.