Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specif ....Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specificity and develop state-of-the-art modelling technologies to improve knowledge of environmental influence on endothelial cell fate and function. This should provide a new framework to modulate the adaptive capacities of endothelial cells and can potentially enable more predictive and targeted drug efficacy and safety testing.Read moreRead less
Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The kn ....Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The knowledge gained from this work will inform and guide future novel approaches, such as in assisted reproductive technologies or regenerative medicine.Read moreRead less
Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and reg ....Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and regeneration. Ultimately, this work aims to identify metabolic dependencies required for organ growth and regeneration. Expected outcomes include scholarly publications revealing fundamental principles underlying tissue growth, new resources for the research community and training for research students.Read moreRead less
Engineering solutions for the next generation of offshore oil and gas infrastructure. Offshore extraction of oil and gas reserves is a key industry for Australia, annually contributing A$21 billion to the economy, and underpinning much of our prosperity. With reserves close to shore being exhausted and A$1 trillion of gas reserves (four times that already developed) known to be 'stranded' in deep and remote locations, the outcomes of the proposed research programme will help scientifically under ....Engineering solutions for the next generation of offshore oil and gas infrastructure. Offshore extraction of oil and gas reserves is a key industry for Australia, annually contributing A$21 billion to the economy, and underpinning much of our prosperity. With reserves close to shore being exhausted and A$1 trillion of gas reserves (four times that already developed) known to be 'stranded' in deep and remote locations, the outcomes of the proposed research programme will help scientifically underpin the reliable design of the next generation of Australia's exploration and development infrastructure. It continues Australia's leadership in the field of offshore geotechnics and engineering, fostering tomorrow's engineering leaders and ensuring the future competitiveness of Australia's offshore oil and gas industry.Read moreRead less
Seabed engineering to unlock Australia's deepwater oil and gas resources. The development of offshore petroleum contributes $25 billion annually to the Australian economy. The majority of our $1 trillion of reserves are currently untapped, being in deep water, remote from shore. This Fellowship will generate a scientific understanding of the mechanics of seabed sediments when disturbed by infrastructure and ocean storms, and lead to procedures for designing the seabed pipelines and facilities ne ....Seabed engineering to unlock Australia's deepwater oil and gas resources. The development of offshore petroleum contributes $25 billion annually to the Australian economy. The majority of our $1 trillion of reserves are currently untapped, being in deep water, remote from shore. This Fellowship will generate a scientific understanding of the mechanics of seabed sediments when disturbed by infrastructure and ocean storms, and lead to procedures for designing the seabed pipelines and facilities needed to unlock Australia's isolated deep water petroleum reserves. These procedures will provide economic solutions for safely transmitting the hydrocarbons to shore. The resulting expertise will enhance Australia's global reputation in offshore geotechnics and engineering and raise the competitiveness of our petroleum industry.Read moreRead less
Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be ca ....Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be catastrophic. By establishing an improved understanding of internal erosion as a sequence of processes on various scales, from the onset of erosion until the failure of the structure, this project will place Australia at the forefront of dam safety assessment.Read moreRead less
Behaviour and design of concrete-filled stainless steel tubular columns at ambient and elevated temperatures. Stainless steel is recognised as an advanced construction material for its merits of corrosion resistance, attractive appearance and ease of maintenance. It has enormous potential for use in steel-concrete composite construction, which will provide the structural engineering community with greater choice in terms of aesthetics, constructability, cost and sustainability. The research put ....Behaviour and design of concrete-filled stainless steel tubular columns at ambient and elevated temperatures. Stainless steel is recognised as an advanced construction material for its merits of corrosion resistance, attractive appearance and ease of maintenance. It has enormous potential for use in steel-concrete composite construction, which will provide the structural engineering community with greater choice in terms of aesthetics, constructability, cost and sustainability. The research put forward in this proposal will promote the better use of stainless steel in Australia's building, bridge and offshore infrastructure, thereby providing significant socio-economic benefits to Australia. Moreover it will greatly increase Australia's infrastructure maintenance capability.Read moreRead less
Bottom-up multiscale modelling of expansive soils in natural environments . Expansive soils, highly sensitive to the environment, undergo dramatic strength and volume changes. This project aims to advance our understanding of expansive soils under different temperatures, hydraulic conditions, mechanical loads, and aqueous salinities. The project expects to use a combination of multidisciplinary knowledge, multiscale experiments and numerical simulations. The outcomes are a new multiscale model a ....Bottom-up multiscale modelling of expansive soils in natural environments . Expansive soils, highly sensitive to the environment, undergo dramatic strength and volume changes. This project aims to advance our understanding of expansive soils under different temperatures, hydraulic conditions, mechanical loads, and aqueous salinities. The project expects to use a combination of multidisciplinary knowledge, multiscale experiments and numerical simulations. The outcomes are a new multiscale model and advanced analysis/design tool for evaluating the performance of expansive soils under different conditions. The outcomes should provide the efficient way to mitigate the significant damage caused to infrastructure by expansive soils and facilitate the application of expansive soil products in waste disposal systems.Read moreRead less
Direct geothermal energy: harnessing an emerging technology. To mitigate the impacts of climate change, the demand for renewable energy technologies with low greenhouse gas (GHG) emissions is rapidly becoming a global priority. Direct geothermal systems use shallow ground as a heat source and sink for heating and cooling buildings, using ground heat exchangers (GHEs) and heat pumps. Substituting common heating and cooling systems with geothermal ones can reduce energy consumption by up to 75 per ....Direct geothermal energy: harnessing an emerging technology. To mitigate the impacts of climate change, the demand for renewable energy technologies with low greenhouse gas (GHG) emissions is rapidly becoming a global priority. Direct geothermal systems use shallow ground as a heat source and sink for heating and cooling buildings, using ground heat exchangers (GHEs) and heat pumps. Substituting common heating and cooling systems with geothermal ones can reduce energy consumption by up to 75 per cent and thus greenhouse gas emissions, since 91 per cent of electricity comes from fossil fuels in Australia. This project aims to develop new full scale physical and numerical models which will allow studying the effects of GHE configuration and intermittent use on efficiency and which will lead towards improving the poor and scarce existing design techniques.Read moreRead less
Designing functional biomaterials with superior cellular interactions. This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffo ....Designing functional biomaterials with superior cellular interactions. This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffolds with a superior ability to promote the development of new tissue, and 2) create surfaces that will enable us to answer fundamental scientific questions regarding cell adhesion and cell/material interactions.Read moreRead less