Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. ....Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. This project will develop new cost-effective methods for designing against rock fall events using a combination of advanced testing and computer modelling.Read moreRead less
Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and ....Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and remediation. Development of accurate predictions is expected to be achieved through physical model testing, numerical modelling and analysis of field data. Predictions should improve subsea reliability and lead to omission of scour protection in some situations, increasing international competitiveness of our offshore oil and gas industry.Read moreRead less
Vaporization of heavier gas oil in Fluid Catalytic Cracking risers. Fluid Catalytic Cracking (FCC) is an important refinery operation responsible for about 45 per cent of the total petrol produced. The project is aimed at improving production efficiency of Australian refineries by applying fundamental modelling to the FCC. The outcomes will enable refiners to produce cleaner fuel and decrease greenhouse gas emissions.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100053
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an underst ....State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an understanding of the various methods available, and their capabilities and limitations, through systematic research projects. Very little research has been done in Australia and overseas in this area due to lack of facilities. This state-of-the-art testing equipment will provide Australian institutions with a cutting edge facility with portable equipment for NDT related research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100130
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure ....An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure and the ground under such loading. The shaking table will simulate earthquakes and enable controlled testing of three-tonne models of foundation and soil-structure interaction systems typical of Australia's infrastructure. The discoveries made are expected to be integral to the modernisation of Australia's seismic design standards so that earthquake-induced damage and risk exposure can be minimised.Read moreRead less
Harnessing the power of oceans: anchors for floating energy devices. This project aims to establish a geotechnical design framework for shared anchoring systems subjected to multidirectional cyclic loading for large integrated arrays of floating wind turbines and floating wave energy converters. This is expected to facilitate new, economic foundation solutions, generating radical cost savings to help unlock Australia's renewable ocean energy resources. The project aims to utilise a blend of stat ....Harnessing the power of oceans: anchors for floating energy devices. This project aims to establish a geotechnical design framework for shared anchoring systems subjected to multidirectional cyclic loading for large integrated arrays of floating wind turbines and floating wave energy converters. This is expected to facilitate new, economic foundation solutions, generating radical cost savings to help unlock Australia's renewable ocean energy resources. The project aims to utilise a blend of state-of-the-art centrifuge modelling techniques and numerical modelling, incorporating an energy-based method and yield envelopes. This innovative methodology aims to establish a validated framework for understanding and predicting foundation performance under the complex load histories arising in renewable ocean energy applications.Read moreRead less
Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization ....Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization tools and numerical models. The final outcome of the project will be a set of designs of the columns, which should be more efficient, safer and cheaper to operate, and have smaller physical and environmental footprints, thus helping the Australian LNG industry to stay globally competitive.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100058
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materi ....Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materials are often subjected to existing confining stresses. The full-field optical techniques, with an ultra-high speed and resolution camera in the system, aims to assist the quantitative measurement of deformation fields including small strain induced in brittle material's failure and identification of constitutive parameters.Read moreRead less