Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Rethinking auditory alarms. This project aims to investigate whether auditory displays that give listeners background information about the status of monitored processes will lead to better situation awareness than conventional auditory alarms. Recent efforts to combat alarm fatigue by reducing auditory alarms may cause listeners to lose awareness of early process deterioration and its context. This project will investigate benefits of intermittent displays summarising process status with sound ....Rethinking auditory alarms. This project aims to investigate whether auditory displays that give listeners background information about the status of monitored processes will lead to better situation awareness than conventional auditory alarms. Recent efforts to combat alarm fatigue by reducing auditory alarms may cause listeners to lose awareness of early process deterioration and its context. This project will investigate benefits of intermittent displays summarising process status with sound or time-compressed speech while participants perform specific ongoing tasks. Anticipated outcomes are safer, more effective and better tolerated ways of monitoring processes than conventional auditory alarms. Results apply to healthcare, transportation and process industries.Read moreRead less