Special Research Initiatives - Grant ID: SR0354474
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Metals in Medicine. Metal-based drugs account for several billion dollars of pharmaceutical sales worldwide, but proportionally much less research and development has focussed on this area than organic drugs. Australia has played a pivotal role in the early development of metal-based pharmaceuticals, which remains a research strength. The dual aims of the initiative are to provide a network for a vibrant industry based around metals in medicine and to improve the health of Australians. The ini ....Metals in Medicine. Metal-based drugs account for several billion dollars of pharmaceutical sales worldwide, but proportionally much less research and development has focussed on this area than organic drugs. Australia has played a pivotal role in the early development of metal-based pharmaceuticals, which remains a research strength. The dual aims of the initiative are to provide a network for a vibrant industry based around metals in medicine and to improve the health of Australians. The initiative will foster national and international cross-disciplinary collaborations to address the impediments holding back Australia's potential to take full advantage of our research strength in metals in medicine.Read moreRead less
Molecular toxinology of Australia's lesser known venomous snakes. This proposal represents a tremendous opportunity for biodiscovery from venomous snakes. This will be achieved through the researchers' unique approach of investigating previously unmapped venom systems for divergent, bioactive proteins. An understanding of venomous animal protein evolution great potential in drug discovery and other commercial applications. This project will provide Australian graduate and post-graduate stude ....Molecular toxinology of Australia's lesser known venomous snakes. This proposal represents a tremendous opportunity for biodiscovery from venomous snakes. This will be achieved through the researchers' unique approach of investigating previously unmapped venom systems for divergent, bioactive proteins. An understanding of venomous animal protein evolution great potential in drug discovery and other commercial applications. This project will provide Australian graduate and post-graduate students with finely tuned skills in cutting edge methodological techniques and a fluent understanding of molecular evolution, preparing them to be internationally competitive scientists.Read moreRead less
Natural Therapeutic Products from Shark Bile. Scymnol and its sulfate are natural therapeutic products from shark bile with highly potent anti-oxidant and liver-protective activities. The Industry Partner and Macrides have co-patented the synthesis of scymnol to avoid using scarce natural resources. However, unresolved problems in scale-up of production have prevented them from supplying the growing demands of cosmetic and health food companies. Our research group has recently developed a potent ....Natural Therapeutic Products from Shark Bile. Scymnol and its sulfate are natural therapeutic products from shark bile with highly potent anti-oxidant and liver-protective activities. The Industry Partner and Macrides have co-patented the synthesis of scymnol to avoid using scarce natural resources. However, unresolved problems in scale-up of production have prevented them from supplying the growing demands of cosmetic and health food companies. Our research group has recently developed a potential synthetic route for scymnol sulfate. The present project aims to develop a commercially-viable scale-up of this synthesis for manufacturing scymnol and scymnol sulfate to solve current supply problems; and to provide essential safety information for their appropriate use; and evaluate potential new therapeutic uses.Read moreRead less
Pharmacological and biochemical characterisation of Australian mygalomorph spider venoms. This project will increase our limited knowledge of Australian mygalomorph venoms by isolation, identification and characterisation of novel toxins in theraphosid and Northern mouse-spider venoms. Thereby, the scientific basis for the treatment of mygalomorph spider bites might be improved. Secondly, new insights into pharmacology and the potential development of novel therapeutics and molecular probes of t ....Pharmacological and biochemical characterisation of Australian mygalomorph spider venoms. This project will increase our limited knowledge of Australian mygalomorph venoms by isolation, identification and characterisation of novel toxins in theraphosid and Northern mouse-spider venoms. Thereby, the scientific basis for the treatment of mygalomorph spider bites might be improved. Secondly, new insights into pharmacology and the potential development of novel therapeutics and molecular probes of target molecules might be expected.Read moreRead less
Understanding And Ameliorating The Human Health Effects Of Exposure To Air Pollution: From Knowledge To Policy And Public Health Practice
Funder
National Health and Medical Research Council
Funding Amount
$2,584,848.00
Summary
Urban consolidation and sprawl, traffic congestion, mining, climate change, heating and cooling living environments, and power generation – these manifestations of modernity produce regular headlines. Air pollution and its effects on human health are the focus of much popular concern. This CRE will build an integrated research capacity in the field of air pollution and its effects on human health that will allow Australia to address these major challenges - now and in the future.
Mindfulness and coping in chronic illness: insights from a study of joint replacement surgery. This study investigates whether participation in a mental health enhancement program (mindfulness) will improve the recovery of patients undergoing total joint replacement. This will benefit patients by promoting psychological well-being which has direct effects on pain and physical function after surgery.
Program evaluation of the osteoarthritis awareness hub. Persons with osteoarthritis generally have poor knowledge about their disease and its appropriate management. The aim of this project is to evaluate whether improved knowledge, and management decisions of persons with osteoarthritis, can ultimately lead to improved health outcomes.
The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present a ....The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present an opportunity to control hypertension whilst simultaneously limiting fibrosis in the kidney. Renal failure is steadily increasing and is now the single largest health care cost to the community. These studies will provide the proof of concept required to ultimately bring this novel preventative therapy to the community.Read moreRead less
Deakin Family Options: engaging youth with high prevalence mental health problems using family based interventions. Youth depression, anxiety and substance abuse are prevalent, distressing and costly problems impacting one in five young Australians. This collaborative project - called ‘Deakin Family Options’ - will evaluate a family based intervention in order to broaden the therapeutic approaches used for young people and their families.
Reg growth factors in gastric regeneration and disease. This project will obtain a more detailed knowledge of the role that growth factors play in helping the lining of the stomach repair itself after damage caused by disease. Growth factors may also play a role in causing stomach cancer. To do this we will examine the expression of growth factors in number of stomach diseases and cancer and assay the ability of growth factors to promote the growth of stomach cells.
This work is that it will co ....Reg growth factors in gastric regeneration and disease. This project will obtain a more detailed knowledge of the role that growth factors play in helping the lining of the stomach repair itself after damage caused by disease. Growth factors may also play a role in causing stomach cancer. To do this we will examine the expression of growth factors in number of stomach diseases and cancer and assay the ability of growth factors to promote the growth of stomach cells.
This work is that it will contribute to our knowledge of how cell growth in the stomach is controlled under normal circumstances and in the very common pathological conditions of tissue damage, inflammation and cancer. It may also help us understand how inflammation can in some circumstances lead to cancer.Read moreRead less