Endocrine And Molecular Regulation Of Placental CRH Expression
Funder
National Health and Medical Research Council
Funding Amount
$466,980.00
Summary
Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotr ....Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotrophin releasing hormone, CRH) in the placenta and the length of time the baby is carried in the mother. In women who will deliver prematurely a rise in CRH occurs earlier in the pregnancy and more rapidly, while in women who deliver late the rise occurs more slowly. This work has given rise to the concept of a biological clock that determines the length of time the fetus will be carried by the mother before birth, and in which production of CRH in the placenta plays a central role. We have been studying how the CRH gene is controlled in placental cells. We have discovered some regions in the DNA of the CRH gene which have important roles in controlling how much CRH is made by the placenta. The experiments described in this research project will determine the molecular mechanisms that control the production of CRH in the human placenta. This will be done in two ways: (1) by examining the DNA sequences involved in controlling expression of the CRH gene and (2) by identifying the proteins that actually perform the regulating functions that result in either increased or decreased amounts of CRH being produced by the placenta. This important information will help us better understand how normal and abnormal birth is controlled, and from that knowledge new ways to detect and prevent premature birth can be invented.Read moreRead less
Overseeing the internet: new paradigms of network measurement. Like the electricity network, the internet is a core infrastructure, and so must be reliable and efficient. A gap in bandwidth supply is like a blackout in terms of lost business and productivity. This project will provide the measurement breakthroughs to ensure that network behaviour can be accurately and comprehensively monitored.
Low-Complexity Capacity-Scalable Multiple Antenna Wireless Communications. The project aims to develop innovative solutions for low-complexity, capacity-scalable multiple antenna wireless communications, in order to meet future data rate requirements whilst maintaining a practical system at a sustainable cost. By leveraging delay-Doppler domain channel properties and geometric reciprocity, pragmatic transceiver technologies and innovative delay-Doppler domain signal processing algorithms for cha ....Low-Complexity Capacity-Scalable Multiple Antenna Wireless Communications. The project aims to develop innovative solutions for low-complexity, capacity-scalable multiple antenna wireless communications, in order to meet future data rate requirements whilst maintaining a practical system at a sustainable cost. By leveraging delay-Doppler domain channel properties and geometric reciprocity, pragmatic transceiver technologies and innovative delay-Doppler domain signal processing algorithms for channel prediction and multi-user transmissions will be developed. The outcomes of the project are expected to significantly improve users' data rates with low system complexity and reduced signalling overhead for future wireless communications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100028
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
A national facility for in situ testing of soft soils. A mobile in situ testing laboratory will permit the investigation of devices for measuring geotechnical conditions on soft and swampy sites which are often being encountered on key infrastructure projects. The new facility will improve the modelling and testing of soft soils and ensure the safe and economic development of Australian infrastructure.
Fatigue Strengthening of Metallic Bridges using Carbon Fibre Reinforced Polymer System. A large number of metallic structures such as bridges, offshore platforms and large mining equipment are aging. Retrofitting such structures is becoming increasingly important in the 21st century. Using an advanced material, Carbon Fibre Reinforced Polymer (CFRP), to strengthen metallic structures is very promising. This project aims to develop reliable CFRP strengthening systems for aging metallic bridges. I ....Fatigue Strengthening of Metallic Bridges using Carbon Fibre Reinforced Polymer System. A large number of metallic structures such as bridges, offshore platforms and large mining equipment are aging. Retrofitting such structures is becoming increasingly important in the 21st century. Using an advanced material, Carbon Fibre Reinforced Polymer (CFRP), to strengthen metallic structures is very promising. This project aims to develop reliable CFRP strengthening systems for aging metallic bridges. It aims to make a breakthrough in understanding of the fatigue crack propagation in CFRP-metal composite system under combined loading. It intends also to produce practical guidelines for engineers to strengthen aging metallic bridges.Read moreRead less
ARC Centre of Excellence for Geotechnical Science and Engineering. To pioneer new scientific approaches for geotechnical design of Australia's energy and transport infrastructure. Australia will spend over $250 billion during the next five years on the provision of physical infrastructure for energy and transport, which is the critical importance to the nation's future prosperity. The Centre for Geotechnical Science and Engineering will develop new computational and experimental approaches to un ....ARC Centre of Excellence for Geotechnical Science and Engineering. To pioneer new scientific approaches for geotechnical design of Australia's energy and transport infrastructure. Australia will spend over $250 billion during the next five years on the provision of physical infrastructure for energy and transport, which is the critical importance to the nation's future prosperity. The Centre for Geotechnical Science and Engineering will develop new computational and experimental approaches to underpin the geotechnical design of this infrastructure and provide a national focus for geotechnical research. New scientific approaches and software for designing cheaper and safer infrastructure in the energy and transport sectors.Read moreRead less
Containment and Reduction of Rework in Transport Mega Projects. Mega transport projects (>$1 billion) are poorly managed during their construction with significant cost and schedule overruns and benefit shortfalls regularly being experienced. Having to perform rework has been identified as a major factor that contributes to these unintended consequences. As there has been limited research that has empirically examined rework causation, an inability to develop effective rework containment and red ....Containment and Reduction of Rework in Transport Mega Projects. Mega transport projects (>$1 billion) are poorly managed during their construction with significant cost and schedule overruns and benefit shortfalls regularly being experienced. Having to perform rework has been identified as a major factor that contributes to these unintended consequences. As there has been limited research that has empirically examined rework causation, an inability to develop effective rework containment and reduction strategies prevails. This research aims to develop a theoretical model that can be used to develop robust containment and reduction strategies to mitigate the adverse economic, productivity and safety consequences that materialize from performing rework during the construction of mega transport projects.Read moreRead less
The National First Nations Research Network will mark a transformation in First Peoples livelihoods and Health Equity. Delivered and led by Indigenous Peoples for Indigenous Peoples, guided by self-determination, this Network will nurture culturally safe environments, connect expertise, catalyse research methods, training and development. The Network will create career pathways to achieve national capability and generational growth, for sustained health and wellbeing of our communities.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.