EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Software Defined Networking: Transforming Emergency Operations. The project aims to improve the effectiveness and efficiency of Australia's emergency operations, for example, bushfire and rescue missions, by providing robust and integrated communications systems for police and the emergency services. Emergency communications systems are currently fragmented by the different technologies, creating disconnected islands of information. The project aims to provide techniques that allow multiple wire ....Software Defined Networking: Transforming Emergency Operations. The project aims to improve the effectiveness and efficiency of Australia's emergency operations, for example, bushfire and rescue missions, by providing robust and integrated communications systems for police and the emergency services. Emergency communications systems are currently fragmented by the different technologies, creating disconnected islands of information. The project aims to provide techniques that allow multiple wireless technologies to communicate seamlessly using modern software-defined networking solutions.Read moreRead less
Real-time internet of thing algorithms with performance guarantees. This project aims to provide efficient, distributed resource allocation algorithms that can perform satisfactorily within time limits imposed by real-time systems. Real-time Internet of Things (IoT) devices will play a significant role in future transport technologies, such as autonomous vehicles and smart traffic management, and will place significant demands upon distributed computing systems to provide timely information upda ....Real-time internet of thing algorithms with performance guarantees. This project aims to provide efficient, distributed resource allocation algorithms that can perform satisfactorily within time limits imposed by real-time systems. Real-time Internet of Things (IoT) devices will play a significant role in future transport technologies, such as autonomous vehicles and smart traffic management, and will place significant demands upon distributed computing systems to provide timely information updates. The computing challenge is to provide reliable, accurate and timely information to IoT devices. The outcomes of this project will directly be beneficial to a variety of IoT applications in transportation, autonomous vehicles, and smart cities. The valuable engineering insights and novel algorithms will support industry, government, and practitioners for future real-time IoT design and deployments.Read moreRead less
Tools and models for measuring and predicting growth in internet addressing and routing complexity. We analyse patterns in the allocation and actual use of Internet Protocol version 4 (IPv4) addresses to predict the technical and market pressures for deployment of IPv6. The utilisation models will help evaluate the potential for emerging markets in scarce IPv4 address prefixes to increase costs to the end-users of Australia's future national broadband network.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100028
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
A national facility for in situ testing of soft soils. A mobile in situ testing laboratory will permit the investigation of devices for measuring geotechnical conditions on soft and swampy sites which are often being encountered on key infrastructure projects. The new facility will improve the modelling and testing of soft soils and ensure the safe and economic development of Australian infrastructure.
Funding on the line: public transport financing and property value capture. This project aims to develop property value capture schemes that would provide alternative funding for public transport infrastructure. It plans to model the timing and spatial patterns of property value uplift from recent investments in rail, busways and ferries in Queensland and New South Wales. It then intends to conduct a survey of Australian stakeholders and discrete choice modelling to determine willingness-to-pay. ....Funding on the line: public transport financing and property value capture. This project aims to develop property value capture schemes that would provide alternative funding for public transport infrastructure. It plans to model the timing and spatial patterns of property value uplift from recent investments in rail, busways and ferries in Queensland and New South Wales. It then intends to conduct a survey of Australian stakeholders and discrete choice modelling to determine willingness-to-pay. This data is then expected to be used to develop an institutionally, legally and politically feasible scheme for implementation in Australia, focused on cases including extension to the Gold Coast light rail network.Read moreRead less
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
The National First Nations Research Network will mark a transformation in First Peoples livelihoods and Health Equity. Delivered and led by Indigenous Peoples for Indigenous Peoples, guided by self-determination, this Network will nurture culturally safe environments, connect expertise, catalyse research methods, training and development. The Network will create career pathways to achieve national capability and generational growth, for sustained health and wellbeing of our communities.
Post-GWAS Functional Characterisation Of Breast Cancer Susceptibility Loci
Funder
National Health and Medical Research Council
Funding Amount
$764,632.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known genes, suggesting that regulatory DNA sequences are responsible for the associated risk. The aim of this proposal is to identify and characterise these DNA sequences. Understanding how sequences variations in these regions contribute to breast cancer will provide novel avenues for therapy.