Defining The Role Of GATA2 In Lymphatic Vascular Development As A Means To Understanding How GATA2 Mutations Predispose To Human Lymphedema.
Funder
National Health and Medical Research Council
Funding Amount
$718,890.00
Summary
We have discovered that mutations in the transcription factor GATA2 result in human primary lymphedema, a debilitating disorder resulting from the failure of lymphatic vessels to return tissue fluid to the bloodstream. The goal of this application is to define the role of GATA2 in lymphatic vessels, in order to understand how GATA2 mutations cause lymphedema. Ultimately, we aim to identify targets to which desperately needed therapeutics for the treatment of lymphedema could be generated.
Deciphering The Transcriptional Program That Instructs Lymphatic Endothelial Cell Fate.
Funder
National Health and Medical Research Council
Funding Amount
$541,950.00
Summary
Lymphatic vessels are essential to maintain fluid balance in most tissues of the human body. Further the lymphatic vasculature plays a central role during cancer and contributes to tumour metastasis. Despite this integral function in health and disease little is known about the molecular programs that coordinate gene expression to build a functional vasculature. This research project will address this gap in our knowledge and will open up new therapeutic avenues for lymphatic vascular disorders
Brain Repair Following Stroke: The Role Of Npas4, A Neural-specific Transcription Factor
Funder
National Health and Medical Research Council
Funding Amount
$611,053.00
Summary
Stroke is the #1 cause of adult disability in Australia and #2 cause of death. About 60,000 Australians suffer a stroke each year while about 250,000 live with the disabilities of stroke, costing over $2B/year. The Queen Elizabeth Hospital and University of Adelaide will study why the Npas4 gene switches on after stroke and the role it plays in brain repair. Future health benefits may be tests to help improve stroke outcome in patients and therapy to decrease loss of brain cells after stroke.
Software Defined Networking: Transforming Emergency Operations. The project aims to improve the effectiveness and efficiency of Australia's emergency operations, for example, bushfire and rescue missions, by providing robust and integrated communications systems for police and the emergency services. Emergency communications systems are currently fragmented by the different technologies, creating disconnected islands of information. The project aims to provide techniques that allow multiple wire ....Software Defined Networking: Transforming Emergency Operations. The project aims to improve the effectiveness and efficiency of Australia's emergency operations, for example, bushfire and rescue missions, by providing robust and integrated communications systems for police and the emergency services. Emergency communications systems are currently fragmented by the different technologies, creating disconnected islands of information. The project aims to provide techniques that allow multiple wireless technologies to communicate seamlessly using modern software-defined networking solutions.Read moreRead less
Characterising Signals Important For Lymphangiogenesis During Development And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$604,938.00
Summary
Lymphatic vessels are a vital component of the cardiovascular system. Abnormalities in the growth and development of lymphatic vessels are associated with human disorders including cancer, lymphoedema and inflammatory diseases. The focus of this application is to characterise signals that direct the construction of lymphatic vessels, with the aim of identifying targets to which novel therapeutics for the treatment of lymphatic vascular diseases could be generated.
Autoconfiguration of critical network infrastructure. In 2000, Vitek Boden hacked into Maroochy Shire's sewerage system, causing hundreds of kilolitres of raw sewage to flow into a public area, causing financial and environmental damage, and the potential for the spread of life-threatening disease. The goal of this project is to improve the security of Australia's critical infrastructure, for instance, electricity and water supply. The project’s approach is to simplify the critical bottlenecks i ....Autoconfiguration of critical network infrastructure. In 2000, Vitek Boden hacked into Maroochy Shire's sewerage system, causing hundreds of kilolitres of raw sewage to flow into a public area, causing financial and environmental damage, and the potential for the spread of life-threatening disease. The goal of this project is to improve the security of Australia's critical infrastructure, for instance, electricity and water supply. The project’s approach is to simplify the critical bottlenecks in communication between plant equipment and company management, namely, the firewall that protects the critical plant equipment from viruses and hackers. Simplification will improve transparency and hence reduce the possibility that security holes allow an incident similar to that of this incident, or worse.Read moreRead less
Internet traffic-matrix synthesis. This project will enhance research and development in Internet engineering by providing basic inputs to test and validate new ideas. The result will be a more efficient, reliable, and robust Internet.
Physical layer security techniques for multiuser wireless networks. This project will develop innovative new security techniques for wireless networks. The novel techniques we develop will exploit the natural variability of wireless communication channels in order to deliver much-enhanced data security to a whole range of applications over the mobile internet.
Discovery Early Career Researcher Award - Grant ID: DE120100016
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Reliable transmission for wireless control. While wireless communication can bring great benefits for control systems, current communication technologies are not competent. This project aims to revolutionise wireless control systems through novel communication strategies. The project will deliver fundamental theories and cutting-edge technologies for communications in control applications.
Intelligent Resource Allocation Techniques for Next Generation Wireless Mobile Communication Networks. The project will develop radio and network resource allocation techniques to maximise network utilisation and to offer guaranteed Quality of Service (QoS) for multimedia traffic in 3G/4G wireless mobile communication networks. In particular, this work will study the problem of radio channel allocation in wireless IP (Internet protocol) multimedia networks. The project will develop resource allo ....Intelligent Resource Allocation Techniques for Next Generation Wireless Mobile Communication Networks. The project will develop radio and network resource allocation techniques to maximise network utilisation and to offer guaranteed Quality of Service (QoS) for multimedia traffic in 3G/4G wireless mobile communication networks. In particular, this work will study the problem of radio channel allocation in wireless IP (Internet protocol) multimedia networks. The project will develop resource allocation algorithms based on traffic conditions, link qualities and service requirements using statistical traffic models, mobile software agents and neural network techniques.
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