Roles Of The EMT Transcription Factors In Epigenetic Remodelling And Myeloid Cell Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$809,520.00
Summary
This project is based upon our novel discoveries that identified ZEB2 and SNAI1 as novel genes involved in the development of aggressive forms of blood cancer. During the course of this proposal we will find new drug targets and new drug treatment options using existing drugs that will specifically target cancer initiating cells in order to kill aggressive forms of blood cancers that are currently refractory to treatment.
Transcriptional Effectors Of Oncogenic ERK Signaling In Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$820,776.00
Summary
This project aims to unravel how one of the most frequently deregulated molecular pathways in colorectal cancer controls the expression of genes required for these tumours to grow and spread. We expect this work to uncover novel therapeutic targets to effectively inactivate this pathway and biomarkers to select patients most likely to benefit from existing therapies.
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Molecular Basis For Stress-induced Gene Regulation—a Model System To Understand Transcriptional Deregulation In Cancer And Neurological Disease
Funder
National Health and Medical Research Council
Funding Amount
$384,076.00
Summary
Deregulated gene transcription plays a critical role in cancer formation. It is therefore important to understand the molecular basis of gene transcription and how tumour cells hijack the process. In this Project, we will study the molecular basis of stress-inducible gene expression. This is particularly important for understanding the molecular basis of cancer as stress-inducible genes are activated by transcription factors implicated in breast, colon, lung, and prostate cancers.
Endocrine And Molecular Regulation Of Placental CRH Expression
Funder
National Health and Medical Research Council
Funding Amount
$466,980.00
Summary
Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotr ....Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotrophin releasing hormone, CRH) in the placenta and the length of time the baby is carried in the mother. In women who will deliver prematurely a rise in CRH occurs earlier in the pregnancy and more rapidly, while in women who deliver late the rise occurs more slowly. This work has given rise to the concept of a biological clock that determines the length of time the fetus will be carried by the mother before birth, and in which production of CRH in the placenta plays a central role. We have been studying how the CRH gene is controlled in placental cells. We have discovered some regions in the DNA of the CRH gene which have important roles in controlling how much CRH is made by the placenta. The experiments described in this research project will determine the molecular mechanisms that control the production of CRH in the human placenta. This will be done in two ways: (1) by examining the DNA sequences involved in controlling expression of the CRH gene and (2) by identifying the proteins that actually perform the regulating functions that result in either increased or decreased amounts of CRH being produced by the placenta. This important information will help us better understand how normal and abnormal birth is controlled, and from that knowledge new ways to detect and prevent premature birth can be invented.Read moreRead less
Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.
Real-time internet of thing algorithms with performance guarantees. This project aims to provide efficient, distributed resource allocation algorithms that can perform satisfactorily within time limits imposed by real-time systems. Real-time Internet of Things (IoT) devices will play a significant role in future transport technologies, such as autonomous vehicles and smart traffic management, and will place significant demands upon distributed computing systems to provide timely information upda ....Real-time internet of thing algorithms with performance guarantees. This project aims to provide efficient, distributed resource allocation algorithms that can perform satisfactorily within time limits imposed by real-time systems. Real-time Internet of Things (IoT) devices will play a significant role in future transport technologies, such as autonomous vehicles and smart traffic management, and will place significant demands upon distributed computing systems to provide timely information updates. The computing challenge is to provide reliable, accurate and timely information to IoT devices. The outcomes of this project will directly be beneficial to a variety of IoT applications in transportation, autonomous vehicles, and smart cities. The valuable engineering insights and novel algorithms will support industry, government, and practitioners for future real-time IoT design and deployments.Read moreRead less
Tools and models for measuring and predicting growth in internet addressing and routing complexity. We analyse patterns in the allocation and actual use of Internet Protocol version 4 (IPv4) addresses to predict the technical and market pressures for deployment of IPv6. The utilisation models will help evaluate the potential for emerging markets in scarce IPv4 address prefixes to increase costs to the end-users of Australia's future national broadband network.
Optical wireless frontier: Design challenges of multi gigabit wireless. This project aims to improve the coverage, mobile access, miniaturisation, bandwidth and networking of optical wireless. As connected machines become the primary consumers of the Internet, technologies for wirelessly connecting devices, processors, storage and display devices at very high speeds become necessary for mission critical services and applications. Gigabit wireless access needs to overcome shortages in the radio-f ....Optical wireless frontier: Design challenges of multi gigabit wireless. This project aims to improve the coverage, mobile access, miniaturisation, bandwidth and networking of optical wireless. As connected machines become the primary consumers of the Internet, technologies for wirelessly connecting devices, processors, storage and display devices at very high speeds become necessary for mission critical services and applications. Gigabit wireless access needs to overcome shortages in the radio-frequency spectrum and provide scalable bandwidth and wider coverage. Optical wireless transmission is a real alternative to current wireless systems because its connection speed of tens of gigabits/second means it can work efficiently with wired optical networking technologies. This project is expected to lead to optical wireless technology.Read moreRead less
Photonics Platform to Transform Mobile Fronthaul Infrastructure. Future wireless systems of mobile networks and defence platforms will need to offer high-speed, low-delay, reliable connectivity and high bandwidth. With the explosive growth of wireless systems, this creates significant challenges in fronthaul - the link connecting antennas with the signal processors and core network. This project aims to design and develop an innovative fronthaul for wireless systems based on a dynamically reconf ....Photonics Platform to Transform Mobile Fronthaul Infrastructure. Future wireless systems of mobile networks and defence platforms will need to offer high-speed, low-delay, reliable connectivity and high bandwidth. With the explosive growth of wireless systems, this creates significant challenges in fronthaul - the link connecting antennas with the signal processors and core network. This project aims to design and develop an innovative fronthaul for wireless systems based on a dynamically reconfigurable, software-defined photonic platform capable of meeting diverse requirements. The outcomes of this project will help build a scalable fronthaul solution to overcome fundamental challenges and realise cost-effective pathways for transforming how future wireless networks and defence platforms are realised.Read moreRead less