Discovering Molecular Signatures Of Human T Follicular Helper Cells And Antibody Producing B Cells To Improve Vaccine Efficacy And Transplation Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
A key way the body can fight off infections is to produce antibodies, a process that requires the coordinated efforts of multiple types of specialised immune cells. A more detailed understanding the factors that govern robust antibody responses is critically needed and will be investigated in this project in the context of vaccination and transplant rejection.
Tumor Targeted T Cells To Enhance Anti-tumor Efficacy And Dictate Umbilical Cord Blood (UCB) Engraftment In The Setting Of Double UCB Transplant.
Funder
National Health and Medical Research Council
Funding Amount
$376,002.00
Summary
Currently, despite cord blood transplantation, most leukemia patients will ultimately die of disease relapse. Therefore, my proposal is focused on improving the effectiveness of cord blood transplantation by further infusion of gene modified umbilical cord derived immune blood cells designed to specifically target and lyse residual leukemia tumor cells. This novel approach this will decrease disease relapse and lead to better patient survival following cord blood transplant therapy.