A Comparison Of Arthroscopic Synovial Biopsy Based Targeted Biologic Therapy Versus Conventional Therapy In Rheumatoid Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better dise ....This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better disease control than the currently prevalent approach.Read moreRead less
The mortality rate from community-acquired pneumonia has not improved over the past four decades. New pulmonary infectious diseases such as due to non tuberculous mycobacteria are causing increasing problems and bronchiectasis is responsible for an ever increasing mortality, morbidity and economic burden on our health system. This grant will support Professor Waterer in continuing to reduce the personal and society burden of pulmonary infections.
Improving Alcohol Treatment Outcomes: The Impact Of Client, Intervention And System Variables On Treatment Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$1,525,879.00
Summary
Patient outcomes are significantly influenced by a number of factors including the characteristics of the patient, the type of treatment provided, and the characteristics of the system in which care is delivered. This study aims to determine how these factors influence outcomes for people seeking treatment for alcohol dependence. It will provide critical information for policy makers on which to base minimum service standards.
Optimising Therapy In Anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
ANCA vasculitis is a rare autoimmune condition causing inflammation in small blood vessels, that can lead to organ failure and death. This research will help identify the best treatment approach for different subgroups of patients and the best timing of certain treatments. We will also explore patient symptoms and experience of this condition, and how this relates to disease activity, damage and medication effects.
Deep Brain Stimulation For Treatment Resistant Major Depression: Neural Correlates And Neuropsychological Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$257,561.00
Summary
Major depression is a prevalent and devastating mental illness. While there are numerous pharmacological and psychological antidepressant therapies available, many patients do not respond to these treatments. Deep Brain Stimulation (DBS) is emerging as a potential treatment option for individuals with chronic severe treatment resistant major depression. The current project will investigate the cognitive and neurobiological outcomes associated with the use of DBS to treat depression.
Fracture Associated Premature Mortality; An International Consortium
Funder
National Health and Medical Research Council
Funding Amount
$579,807.00
Summary
Following an osteoporotic fracture there is an increased premature mortality compared with someone who has not fractured. There is also evidence that anti-osteoporosis medication reduces this premature mortality. This study will determine the size of the fracture-mortality relationship and the effect of treatment on this mortality for different fracture types and in different populations by integrating data from multiple international epidemiology studies of osteoporosis.
A Comparative Clinical Efficacy Trial Of Treatments For Melancholia
Funder
National Health and Medical Research Council
Funding Amount
$309,711.00
Summary
This study seeks to improve treatment of melancholic depression by comparing three treatments, i) a selective serotonin reuptake inhibitor (SSRI), ii) cognitive behaviour therapy (CBT) and, iii) a broad-spectrum antidepressant sequencing treatment approach. We hypothesize that the latter will be superior to both i) SSRI monotherapy, and ii) CBT monotherapy, over a 12-week trial period. Comparisons will be made with the US-based Sequenced Treatment Alternatives to Relieve Depression trial.
Osteoporosis is a common problem with increased premature mortality associated with hip and even more minor fractures. The cause of increased mortality is debated although osteoporosis treatment may decrease this risk. This study will be the first to examine survival of all subjects in NSW admitted for a fracture including cause for subsequent hospitalisation and treatment taken. This study will help define the cause of the mortality and the role of anti osteoporosis treatment on outcome.
Reducing The Burden Of Breast Cancer Through Precision Prevention, Targeted Treatment And Enhanced Survivorship
Funder
National Health and Medical Research Council
Funding Amount
$1,491,192.00
Summary
Breast cancer affects 1 in 8 Australian women. Of all the cancers, breast cancer results in the largest number of years of healthy life lost from death and illness. My research will reduce this unacceptable burden of breast cancer for women and their families. Spanning prevention, through treatment to survivorship, it will facilitate reduced breast cancer incidence, more effective treatments and enhanced understanding of the effects of new treatments on ovarian function and fertility.