ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Driving Change: Using Emergency Department Data To Reduce Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,468,026.00
Summary
The proposed project is a system change within partner emergency departments, providing them the information and tools to act on both risky alcohol consumption in individual patients and the sources of alcohol in the community which cause the harm they experience. Most importantly, the proposed public health interventions act as a tool for emergency departments to regularly raise awareness with the public and policymakers regarding the impact of alcohol on patients, clinicians and hospitals.
Mechanisms Of Glucocorticoid Resistance In Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.
A Multi-setting Intervention To Reduce Sedentary Behaviour, Promote Physical Activity And Improve Childrens Health
Funder
National Health and Medical Research Council
Funding Amount
$860,343.00
Summary
Sedentary behaviours and physical inactivity play a major role in the rising prevalence of obesity among children in Australia. This intervention study will take place in the school and family settings which play a critical role in shaping children's health behaviours. The objective is to determine whether a 2-year behavioural intervention reduces sedentary behaviour and promotes physical activity and results in improved health among 8-9 year old children.
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
Understanding and responding to online child sexual exploitation offenders. The development of online communication technologies has facilitated a growth in online child sexual exploitation over the past two decades. Using a data-linkage framework, this project aims to enhance understanding of online child sexual exploitation, the legal frameworks surrounding this issue, and the unique characteristics, risks and needs of online sexual offenders. Expected outcomes include increased knowledge to i ....Understanding and responding to online child sexual exploitation offenders. The development of online communication technologies has facilitated a growth in online child sexual exploitation over the past two decades. Using a data-linkage framework, this project aims to enhance understanding of online child sexual exploitation, the legal frameworks surrounding this issue, and the unique characteristics, risks and needs of online sexual offenders. Expected outcomes include increased knowledge to inform current law enforcement and sentencing practices and the development of risk assessment and intervention protocols for clinical use with online offenders. This should increase evidence-based practice with online sexual offenders and assist in preventing the sexual exploitation of children online and in the community.Read moreRead less
Understanding Australia by analysing wastewater during the Census 2021 . This project aims to utilise the Australian Census 2021, a unique opportunity to link exposure to chemical and biological hazards with catchment socio-demographic data via systematic wastewater analysis. The project is expected to advance our capabilities to identify emerging hazards and understand factors that affect spatiotemporal trends in hazards across Australia. Moreover, in a world first, the project aims to assess c ....Understanding Australia by analysing wastewater during the Census 2021 . This project aims to utilise the Australian Census 2021, a unique opportunity to link exposure to chemical and biological hazards with catchment socio-demographic data via systematic wastewater analysis. The project is expected to advance our capabilities to identify emerging hazards and understand factors that affect spatiotemporal trends in hazards across Australia. Moreover, in a world first, the project aims to assess chemical fate on a national level by linking sales/use with fate and release from wastewater treatment plants and assess treatment efficiency at >100 plants around Australia. The project expects to provide insight for government, wastewater managers and industry into hazards that may affect environmental and human health.Read moreRead less
Parole in crisis? Public opinion on the use of parole. Serious crimes committed by parolees in Australia have brought parole into the public eye. Without concrete evidence, governments often act on the assumption that the public holds punitive attitudes. This project is expected to develop an evidence base to inform policy on parole at a crucial time when governments are under pressure to restrict its use. Three mixed-method studies aim to assess: what public views on parole are; why the public ....Parole in crisis? Public opinion on the use of parole. Serious crimes committed by parolees in Australia have brought parole into the public eye. Without concrete evidence, governments often act on the assumption that the public holds punitive attitudes. This project is expected to develop an evidence base to inform policy on parole at a crucial time when governments are under pressure to restrict its use. Three mixed-method studies aim to assess: what public views on parole are; why the public holds these views; and what influence these views have on policy and practice. The project is expected to make contributions to: creating information strategies that properly inform the public; supporting prisoner reintegration strategies; and shaping criminal justice policies based on informed community feedback.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100035
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Critical Resources for the Future. The proposed ARC Training Centre in Critical Resources aims to train the next generation of geoscientists needed to enable resourcing of the transition to a high-tech, clean energy society. Training of PhD students and postdoctoral scientists will primarily focus on bridging the gap between mineral systems science, mineral exploration protocols and ore processing/metallurgical extraction. This will provide geoscientists with an essential ....ARC Training Centre in Critical Resources for the Future. The proposed ARC Training Centre in Critical Resources aims to train the next generation of geoscientists needed to enable resourcing of the transition to a high-tech, clean energy society. Training of PhD students and postdoctoral scientists will primarily focus on bridging the gap between mineral systems science, mineral exploration protocols and ore processing/metallurgical extraction. This will provide geoscientists with an essential understanding of the whole value chain of the critical resources of the future.
Read moreRead less
Reducing direct greenhouse gas emissions from urban wastewater systems. This project aims to develop a systematic framework for water utilities to monitor and reduce direct greenhouse gas (GHG) emissions from wastewater systems. A standardised monitoring protocol will be developed to conduct an unprecedented nationwide sampling campaign. The obtained data, with microbial characterisation and mechanism analysis, will be used to develop novel models for accurate prediction of GHG emissions. Expect ....Reducing direct greenhouse gas emissions from urban wastewater systems. This project aims to develop a systematic framework for water utilities to monitor and reduce direct greenhouse gas (GHG) emissions from wastewater systems. A standardised monitoring protocol will be developed to conduct an unprecedented nationwide sampling campaign. The obtained data, with microbial characterisation and mechanism analysis, will be used to develop novel models for accurate prediction of GHG emissions. Expected outcomes include protocol to accurately monitor emissions, models to predict emission under various conditions, and mitigation guideline for typical plant configurations. The anticipated benefit is a significant reduction in GHG emissions from urban water industry and support it to meet net-zero-emission goal by 2050.Read moreRead less