Improving Health Outcomes In The Tropical North: A Multidisciplinary Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$5,997,916.00
Summary
Improving Health Outcomes in the Tropical North will strengthen partnerships with research institutions in the NT, Qld, WA, NSW, Vic and SA, by undertaking a research agenda that will help close the gap in Indigenous health disadvantage, protect the north from emerging infectious threats and engage regional neighbours. We will establish a northern Australian network that incorporates Indigenous engagement, mentoring and knowledge translation, and facilitates collaboration with southern partners.
Immunity And Pathogenesis In Tropical And Infectious Diseases: Implications For Vaccines And
Funder
National Health and Medical Research Council
Funding Amount
$15,794,553.00
Summary
Malaria, streptococcal diseases, helminthiases and scabies are diseases of indigenous people on a massive scale, which lack vaccines. We aim to understand the pathogenesis of these diseases and develop vaccines and other treatments to combat them. Team includes senior experts on infectious diseases with long collaborative histories and younger members with impressive credentials. The work proposed also concerns inventive new ways of making such vaccines by novel chemical methods and aspects of d ....Malaria, streptococcal diseases, helminthiases and scabies are diseases of indigenous people on a massive scale, which lack vaccines. We aim to understand the pathogenesis of these diseases and develop vaccines and other treatments to combat them. Team includes senior experts on infectious diseases with long collaborative histories and younger members with impressive credentials. The work proposed also concerns inventive new ways of making such vaccines by novel chemical methods and aspects of delivery.Read moreRead less
The Darwin Prospective Melioidosis Study: Years 27-31
Funder
National Health and Medical Research Council
Funding Amount
$1,281,718.00
Summary
The Darwin Prospective Melioidosis Study has documented 914 cases since 1989, with 115 fatalities. A surge in Darwin melioidosis cases over the past 5 years has been linked to urban development and the discovery of a new bacterial strain. Whole genome sequencing of our unique 25+ year set of bacteria and their linked patient data will unravel the changing epidemiology and identify important virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.
Generation of bananas with resistance to Fusarium wilt. Bananas are an important fruit crop in Australia, but the industry is continually threatened by numerous diseases such as Fusarium wilt. This project aims to generate transgenic banana plants with resistance to Fusarium wilt, a disease for which no effective control strategies currently exist.
Manipulation of apoptosis-related genes to generate novel disease resistances in banana. Bananas are one of Australia's most important fruit crops. However, the industry is continually threatened by numerous diseases including yellow and black Sigatoka, Fusarium wilt and bunchy top. Control of these diseases currently requires either extensive pesticide treatments or complex agronomic procedures, of which most are ineffective, expensive or environmentally damaging. The aim of this project is to ....Manipulation of apoptosis-related genes to generate novel disease resistances in banana. Bananas are one of Australia's most important fruit crops. However, the industry is continually threatened by numerous diseases including yellow and black Sigatoka, Fusarium wilt and bunchy top. Control of these diseases currently requires either extensive pesticide treatments or complex agronomic procedures, of which most are ineffective, expensive or environmentally damaging. The aim of this project is to utilise a novel strategy to generate transgenic bananas with resistance to these diseases. The benefit will be both economic and environmental as implementation should significantly reduce or eliminate pesticide use. Importantly, this strategy can potentially be extrapolated to many other crops.Read moreRead less
Maximising pineapple production for Australian farmers using genome editing. This project addresses the single biggest issue affecting the viability of pineapple farming in Australia and internationally: premature flowering leading to supply collapse. We aim to develop CRISPR technology to breed new pineapple varieties using non-GM approaches. Expected outcomes include the production of pineapples with resistance to premature flowering, as well as the technologies to deliver additional improveme ....Maximising pineapple production for Australian farmers using genome editing. This project addresses the single biggest issue affecting the viability of pineapple farming in Australia and internationally: premature flowering leading to supply collapse. We aim to develop CRISPR technology to breed new pineapple varieties using non-GM approaches. Expected outcomes include the production of pineapples with resistance to premature flowering, as well as the technologies to deliver additional improvements in the future. The new varieties will benefit farmers through increased production, maximising supply capability for a rapidly growing internal demand. This will benefit Australian pineapple producers through higher profitability in existing markets, as well as enabling expansion into international and future markets.Read moreRead less
Molecular Epidemiology Of Melioidosis In Australia
Funder
National Health and Medical Research Council
Funding Amount
$357,875.00
Summary
Melioidosis is an important infection in northern Australia. It is a common cause of fatal pneumonia and blood infection in the region. Two outbreaks of melioidosis with fatalities occurring in remote Aboriginal communities have been linked to contamination of the community water supply with the melioidosis bacteria, Burkholderia pseudomallei. In addition, a rare form of melioidosis affecting the brain and spinal cord has resulted in a number of deaths in healthy Aboriginal people and also a num ....Melioidosis is an important infection in northern Australia. It is a common cause of fatal pneumonia and blood infection in the region. Two outbreaks of melioidosis with fatalities occurring in remote Aboriginal communities have been linked to contamination of the community water supply with the melioidosis bacteria, Burkholderia pseudomallei. In addition, a rare form of melioidosis affecting the brain and spinal cord has resulted in a number of deaths in healthy Aboriginal people and also a number left living in remote communities with severe disabilities such as complete paralysis of both legs. Melioidosis has also been identified in two outbreaks occurring over many years in separate locations in southern Australia. It is thought that it may have been introduced to these regions by imported animals, eg via cattle drives, and human fatalities have occurred after local flooding in these temperate locations. This project is built on the ongoing melioidosis collaboration between researchers in Western Australia, the Northern Territory and Queensland. The aim is to use new DNA fingerprinting methods developed specifically for the melioidosis bacteria to understand better why melioidosis can be such a severe disease and how it spreads from the environment to humans and animals and also how it has possibly spread within Australia and overseas. Better recognition and treatment of melioidosis has resulted in a halving of the death rate from this disease in northern Australia (mortality decreased from 40%-18%). This study aims to give us a better understanding of how this soil and water bacteria interacts with humans to cause such severe disease and will hopefully result in new primary preventative measures to complement the improved diagnosis and treatment.Read moreRead less
Molecular tracing of spectacled flying-fox (Pteropus conspicillatus) movements in rainforests and orchards of wet tropical Queensland. This project uses molecular markers to trace movements of spectacled flying-foxes in the wet tropics of north Queensland. The intention is to determine the origins of bats visiting orchards, determine patterns of seasonal and intra-seasonal migration of bats and to document the significance of such migrations to estimation of population numbers and trends. These ....Molecular tracing of spectacled flying-fox (Pteropus conspicillatus) movements in rainforests and orchards of wet tropical Queensland. This project uses molecular markers to trace movements of spectacled flying-foxes in the wet tropics of north Queensland. The intention is to determine the origins of bats visiting orchards, determine patterns of seasonal and intra-seasonal migration of bats and to document the significance of such migrations to estimation of population numbers and trends. These data are critical to conservation of bat populations, to the ecologically sustainable development of fruit growing in the region and the long term sustainable management of the Wet Tropics World Heritage Area.Read moreRead less
Strength in uniformity - novel clonal technologies for a more productive avocado industry. Cost and time efficient clonal propagation protocols to multiply elite avocado rootstocks for increased productivity is a major industry gap. This project will develop novel approaches coupling tissue culture with recent advances in root induction, which will profitably deliver large numbers of uniform and high yielding avocado plants to national and international growers.
High-value horticulture and global production networks in coastal Australia. High-value horticulture is booming in Australia’s north-eastern coastal strip, where a multifunctional landscape also provides various recreational, cultural and environmental services. This project aims analyses how incorporation within agricultural global production networks interacts with diverse drivers of landscape change to shape regional development outcomes. This will contribute to global production network theo ....High-value horticulture and global production networks in coastal Australia. High-value horticulture is booming in Australia’s north-eastern coastal strip, where a multifunctional landscape also provides various recreational, cultural and environmental services. This project aims analyses how incorporation within agricultural global production networks interacts with diverse drivers of landscape change to shape regional development outcomes. This will contribute to global production network theory by developing the territorial nexus of these networks. Expected outcomes include improved policy formulations capable of orchestrating a sustainable and equitable future for rural regions and livelihoods within Australia, with broader contributions to understanding rural development pathways elsewhere in the world.Read moreRead less