Development Of Therapeutically Useful Human Artificial Chromosomes For Gene Delivery And Optimal Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$496,986.00
Summary
Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in ....Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in terms of infection, immune response, and germline modification. We have developed the first stage of a new technology for gene delivery that does not require the use of viruses. This technology is based on the generation of human artificial chromosomes, which are smaller versions of the naturally occurring chromosomes that carry all the genes inside our cells. Safety in these artificial chromosomes comes from the use of entirely human materials for their engineering. These artificial chromosomes also have other advantages over the viral approaches, including allowing large genes to be carried, and providing a permanent cure in a single treatment. We have already successfully constructed, published, and patented a number of first-generation human artificial chromosomes. The current project aims to complete the next proof-of-concept milestone towards the further development of this technology. Specifically, we propose to demonstrate the ability of the artificial chromosomes to carry genes and provide sustainable expression of these genes in cells and in animal models. Success in this study will allow the technology to proceed rapidly into commercialisation and clinical trial as a new improved tool for gene delivery and gene therapy.Read moreRead less
The Awakening of Faith and New Confucian Philosophy. This project aims to provide a new understanding of how New Confucian philosophy was constructed in modern China. It proposes to debunk the prevailing myth that modern Chinese philosophy owes its identity as a continuation of Confucianism, to the exclusion of the fundamentally ‘foreign’ influence of Buddhism. It is anticipated that this project will substantially advance the knowledge base of Chinese philosophy both in Australia and internatio ....The Awakening of Faith and New Confucian Philosophy. This project aims to provide a new understanding of how New Confucian philosophy was constructed in modern China. It proposes to debunk the prevailing myth that modern Chinese philosophy owes its identity as a continuation of Confucianism, to the exclusion of the fundamentally ‘foreign’ influence of Buddhism. It is anticipated that this project will substantially advance the knowledge base of Chinese philosophy both in Australia and internationally, and will also contribute to a more informed understanding of the philosophical and religious traditions our neighbours use to define national and cultural identity.Read moreRead less
Governance for Gender Inclusion: Levelling the Field in Australian Sport. This project aims to understand why, despite gains in women's sport participation, gender inclusion efforts in Australian sport have not yet led to gender parity in leadership roles or broad accessibility for marginalised groups. It seeks to generate new knowledge about the regulatory mechanisms and social conditions that facilitate change through the development of a new interdisciplinary conceptual framework. Expected ou ....Governance for Gender Inclusion: Levelling the Field in Australian Sport. This project aims to understand why, despite gains in women's sport participation, gender inclusion efforts in Australian sport have not yet led to gender parity in leadership roles or broad accessibility for marginalised groups. It seeks to generate new knowledge about the regulatory mechanisms and social conditions that facilitate change through the development of a new interdisciplinary conceptual framework. Expected outcomes include enhanced analytic guidelines and robust recommendations for governance strategies, which can be applied to study other domains. This should provide significant theoretical and policy benefits by supporting equity in professional settings and health promotion through wider inclusion.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100561
Funder
Australian Research Council
Funding Amount
$452,936.00
Summary
Solving the disability data puzzle to ensure progress towards equity. In South Korea, the average age of death for people with disability is 16 years younger than people without disability. In Australia, we do not have the data infrastructure to generate life expectancy statistics for people with disability. This fellowship aims to solve this disability data challenge, identified as a critical problem by the Australian Government. It will develop a validated methodology for producing disability ....Solving the disability data puzzle to ensure progress towards equity. In South Korea, the average age of death for people with disability is 16 years younger than people without disability. In Australia, we do not have the data infrastructure to generate life expectancy statistics for people with disability. This fellowship aims to solve this disability data challenge, identified as a critical problem by the Australian Government. It will develop a validated methodology for producing disability statistics from linked data; generate a whole population disability data resource to build capacity in disability research; and for the first time, produce life expectancy statistics for people with disability - the ultimate policy tool to monitor progress towards equity and improve the lives of disabled Australians. Read moreRead less
Gender after conflict: a gendered analysis of the international community's engagement in post-conflict zones. Efforts by the international community to transition post-conflict societies into peaceful democracies can be fraught with complex politics. This project seeks to examine the role that the international community's ideas and policies about gender have on the failures and successes of this transition.
Reducing health disparities for older LGBTI Australians. Reducing health disparities for older LGBTI Australians. This project aims to optimise health and aged care services throughout Australia, by bringing together researchers and key organisations in the health, aged, and lesbian, gay, bisexual, transgender and intersex (LGBTI) sectors to build a much-needed evidence base. Older LGBTI Australians have vastly poorer health outcomes than the broader population. This project will provide detaile ....Reducing health disparities for older LGBTI Australians. Reducing health disparities for older LGBTI Australians. This project aims to optimise health and aged care services throughout Australia, by bringing together researchers and key organisations in the health, aged, and lesbian, gay, bisexual, transgender and intersex (LGBTI) sectors to build a much-needed evidence base. Older LGBTI Australians have vastly poorer health outcomes than the broader population. This project will provide detailed quantitative and qualitative data on the challenges and needs of older LGBTI Australians and service providers, and develop essential resources so policymakers and service providers can reduce older LGBTI Australians’ health disparities.Read moreRead less
Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preven ....Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preventative health perspective, the investigation of platelet calcium signalling will greatly accelerate the development of new pharmaceuticals to tackle acute and chronic cardiovascular diseases, such as stroke, heart attack and artherosclerosis. Read moreRead less
A Buddhist Debate and Its Contemporary Relevance. The aim of this project is to engage with one of the central debates in Tibetan philosophy concerning truth, realism and epistemic justification. It plans to explore the implications of this debate for subsequent Tibetan thought and for contemporary Western analytic philosophy. The project plans to analyse previously unstudied texts and demonstrate the fecundity of a traditional method of collaborative cross-cultural philosophy today in which Tib ....A Buddhist Debate and Its Contemporary Relevance. The aim of this project is to engage with one of the central debates in Tibetan philosophy concerning truth, realism and epistemic justification. It plans to explore the implications of this debate for subsequent Tibetan thought and for contemporary Western analytic philosophy. The project plans to analyse previously unstudied texts and demonstrate the fecundity of a traditional method of collaborative cross-cultural philosophy today in which Tibetan and Western scholars work together to develop joint analyses. It may also demonstrate that the metaphysical and epistemological ideas and arguments developed in these debates can contribute to Western philosophy.Read moreRead less
Work, care, retirement and health: ageing agendas. This project will undertake a gendered analysis of how Australians can retire well, taking account of their key resources (such as work, superannuation, the aged pension, and other assets) and key demands (such as to work longer and to care for others in the context of an ageing population and a more feminised workforce).
microRNAs and the control of T lymphocyte differentiation, function and malignant transformation. The molecular mechanism of the immune system is not completely understood. This project will investigate how transcription factors and microRNAs, two major types of regulatory molecules work together to control immune responses. The results from this research will assist in the design of better vaccination strategies and treat certain lymphomas.