Targeted Pelvic Floor Muscle Training For Urinary Incontinence After Radical Prostatectomy: A Randomised Controlled Trial With Embedded Physiological Studies
Funder
National Health and Medical Research Council
Funding Amount
$966,377.00
Summary
Prostatectomy is a common treatment for the most common cancer in men. Survival is good, but many develop debilitating urinary incontinence. Past pelvic floor muscle training has had limited effect, but recent work has changed understanding of how muscles control continence and compensate for surgery. This clinical trial compares innovative training individually tailored to optimise continence, usual exercise and no treatment, and aims to identify men most likely to benefit from treatment.
Neonatal Cranial Ultrasound: Safety, Knowledge And Practice Of Prolonged Or Repeated Exposure To Acoustic Waves
Funder
National Health and Medical Research Council
Funding Amount
$255,055.00
Summary
Ultrasound is routinely used for diagnosis of brain lesions amongst newborns. Animal studies have shown that ultrasound can sometimes be harmful to the brain. We currently have very little information on the characteristics of neonatal cranial scans. This project will investigate current knowledge of safety and training via a nationwide survey, analyse the elements of 'typical' scans and measure brain surface heating after ultrasound amongst neonates.
Developing Functionalised Microbubbles For Molecular Ultrasound Imaging And Targeted Delivery Of Drugs And MicroRNA Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$677,229.00
Summary
We aim to develop gas-filled microbubbles that are directed to markers of thrombosis and inflammation and will allow visualisation of blood clots and early inflammatory reactions via ultrasound. This will allow early and timely treatment. We will systematically test for the best method of microbubble coating with recombinant antibodies in various animal models of thrombosis and inflammation. In addition, we plan to load microbubbles with drugs and target these to areas where they are needed.