The contribution of South Asia to the peopling of Australasia. This project focuses on the human fossil record from three regions critical to understanding the origins of our species, Homo sapiens. Australia is crucial in view of its diverse array of "gracile" and "robust" human remains of Late Pleistocene/early Holocene age. Equally important are South and Southeast Asia as they lined the tropical route between Africa, our species' Late Pleistocene homeland according to the Out of Africa theory ....The contribution of South Asia to the peopling of Australasia. This project focuses on the human fossil record from three regions critical to understanding the origins of our species, Homo sapiens. Australia is crucial in view of its diverse array of "gracile" and "robust" human remains of Late Pleistocene/early Holocene age. Equally important are South and Southeast Asia as they lined the tropical route between Africa, our species' Late Pleistocene homeland according to the Out of Africa theory, and Australia. Osteological and archaeological evidence of the selection pressures that operated on earlier hunter-gatherers will be employed to explain the observed patterns of morphological evolution throughout the study region.Read moreRead less
Small vertebrates from the Albian-Cenomanian of Queensland - testing hypotheses of provincialism among Australia's mid-Cretaceous dinosaur faunas. This project will add to our knowledge of Australian dinosaurs and the world they inhabited. Dinosaurs are often the means through which many people, especially children, are introduced to science. This project has the potential to greatly enhance this attraction to science, using the results of research on Australian dinosaurs. It has direct links wi ....Small vertebrates from the Albian-Cenomanian of Queensland - testing hypotheses of provincialism among Australia's mid-Cretaceous dinosaur faunas. This project will add to our knowledge of Australian dinosaurs and the world they inhabited. Dinosaurs are often the means through which many people, especially children, are introduced to science. This project has the potential to greatly enhance this attraction to science, using the results of research on Australian dinosaurs. It has direct links with a number of national and international museum exhibitions, and in western Queensland the results will be incorporated into a newly developed regional interpretive centre in Isisford. The enormous social and economic benefits linked to this initiative will open up numerous opportunities for local businesses, and increase the appreciation for science and exploration in outback areas.Read moreRead less
Understanding how the primate brain processes visual information. Being able to see is a crucial aspect of our daily lives, which happens so effortlessly that it tends to be taken for granted. In comparison with other animals and artificial systems, the primate visual cortex is unsurpassed in its capacity to interpret complex and dynamic environments, in a manner that is fast and computationally robust. Discovering how this happens in terms of interactions between cells in the brain can help us ....Understanding how the primate brain processes visual information. Being able to see is a crucial aspect of our daily lives, which happens so effortlessly that it tends to be taken for granted. In comparison with other animals and artificial systems, the primate visual cortex is unsurpassed in its capacity to interpret complex and dynamic environments, in a manner that is fast and computationally robust. Discovering how this happens in terms of interactions between cells in the brain can help us design more efficient artificial systems capable of vision. This in turn can have profound implications for the creation of new technologies such as artificial eyes, autonomous robots, and intelligent sensors, and may also result in future benefits for medical science.Read moreRead less
To flee or not to flee: surviving on incomplete information. Even lowly animals, like the Australian fiddler crabs we will be investigating, are surprisingly competent in making the right decisions in complex situations. They actively acquire information and make good use of it to assure their immediate safety and their long term gains. Animals are exquisitely honed by evolution and we would benefit greatly by understanding what makes them so competent: on a theoretical level, we may learn about ....To flee or not to flee: surviving on incomplete information. Even lowly animals, like the Australian fiddler crabs we will be investigating, are surprisingly competent in making the right decisions in complex situations. They actively acquire information and make good use of it to assure their immediate safety and their long term gains. Animals are exquisitely honed by evolution and we would benefit greatly by understanding what makes them so competent: on a theoretical level, we may learn about efficient rules of good decision making and on a practical level, we may be able to design more flexible, robust and clever machines. Besides being useful in this wider context, the results of our research will thus also contribute to a new and 'sophisticated' appreciation of the cognitive design of animal.Read moreRead less
Colour vision in marsupials. The ability to distinguish colours is a crucial aspect of vision, providing vital data for sexual selection, predator detection and food acquisition. Studies of mammalian colour vision have largely overlooked marsupials. Our recent investigation of spectral sensitivity in two Australian species revealed a colour discrimination capacity beyond that of placentals (excluding primates), implying disparate evolutionary pressures in the two groups. We will provide the fi ....Colour vision in marsupials. The ability to distinguish colours is a crucial aspect of vision, providing vital data for sexual selection, predator detection and food acquisition. Studies of mammalian colour vision have largely overlooked marsupials. Our recent investigation of spectral sensitivity in two Australian species revealed a colour discrimination capacity beyond that of placentals (excluding primates), implying disparate evolutionary pressures in the two groups. We will provide the first comprehensive description of colour vision in marsupials, studying species with differing rhythmicities, habitats and diets. Wavelength sensitivity and molecular structure of retinal visual pigments will be assessed in relation to evolutionary influences and ecological demands.
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Anti-ageing role for relaxin in blood vessels. Arteries stiffen with age. This is due to increased arterial smooth muscle tone and alterations in the extracellular matrix. In a sense, the artery undergoes ?fibrosis? with aging. In light of the anti-fibrotic attributes of the peptide hormone relaxin observed in other tissues, this collaborative project will investigate the potential role for relaxin in opposing arterial ?fibrosis? associated with aging. We will test the hypothesis that a reductio ....Anti-ageing role for relaxin in blood vessels. Arteries stiffen with age. This is due to increased arterial smooth muscle tone and alterations in the extracellular matrix. In a sense, the artery undergoes ?fibrosis? with aging. In light of the anti-fibrotic attributes of the peptide hormone relaxin observed in other tissues, this collaborative project will investigate the potential role for relaxin in opposing arterial ?fibrosis? associated with aging. We will test the hypothesis that a reduction in arterial relaxin expression in older animals is a major cause of arterial stiffening. Further studies will investigate the mechanisms by which relaxin administration can alleviate this phenomenon.Read moreRead less
Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action ....Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action in these organs. Our findings will provide important basic information on relaxin physiology and enable us to implement a long-term partnership with Connetics to understand how relaxin regulates collagen production and/or the development of fibrosis.Read moreRead less
Target detection in visual clutter. The interdisciplinary nature of the project will offer a stimulating environment for training a postdoctoral worker in the hot topic of computational neuroscience. While computationally expensive solutions to moving target detection in clutter have been implemented using conventional engineering, this project will offer insight into the efficiency of the biological brain (with benefit of millions of years of evolution towards compact, economical and optimal so ....Target detection in visual clutter. The interdisciplinary nature of the project will offer a stimulating environment for training a postdoctoral worker in the hot topic of computational neuroscience. While computationally expensive solutions to moving target detection in clutter have been implemented using conventional engineering, this project will offer insight into the efficiency of the biological brain (with benefit of millions of years of evolution towards compact, economical and optimal solutions). The results will assist development of efficient artificial intelligence. It will also assist our ongoing collaborations with defence partners to develop and apply algorithms in artificial vision systems. Read moreRead less
Regenerating lizard tails: A model for understanding the process of lymphangiogenesis. In humans, impaired lymphatic drainage in limbs causes the debilitating swelling termed lymphoedema. Lymphoedema affects 500,000,000 people worldwide. In the developed world lymphoedema predominantly results from surgery for cancer, and occurs in approximately 25% of breast cancer patients. We will examine lymph vessel regeneration (lymphangiogenesis) in a naturally regenerating, complex structure (the lizard ....Regenerating lizard tails: A model for understanding the process of lymphangiogenesis. In humans, impaired lymphatic drainage in limbs causes the debilitating swelling termed lymphoedema. Lymphoedema affects 500,000,000 people worldwide. In the developed world lymphoedema predominantly results from surgery for cancer, and occurs in approximately 25% of breast cancer patients. We will examine lymph vessel regeneration (lymphangiogenesis) in a naturally regenerating, complex structure (the lizard tail), to describe the regrowth process and determine the abundance, location, functional properties and molecular control of the new lymphatics. Furthermore, if reptilian lymphatic growth factors can promote lymphangiogenesis in mammals, we can design novel therapeutic approaches using reptilian ligands to promote lymphangiogenesis in lymphoedematous human tissues.Read moreRead less
Organisation of the cerebral cortex- what, if anything, is a cortical area? Currently, much effort is being directed towards elucidating the roles of different regions of the cerebral cortex. "Maps" of cortical areas have become essential points of reference, exerting a powerful influence on the way we think about the brain. However, is it really appropriate to model the cortex as a mosaic of well-defined areas? This project will challenge the assumptions underlying current brain mapping efforts ....Organisation of the cerebral cortex- what, if anything, is a cortical area? Currently, much effort is being directed towards elucidating the roles of different regions of the cerebral cortex. "Maps" of cortical areas have become essential points of reference, exerting a powerful influence on the way we think about the brain. However, is it really appropriate to model the cortex as a mosaic of well-defined areas? This project will challenge the assumptions underlying current brain mapping efforts. Its main benefits will be the refinement of strategies for brain mapping, including potential for better
application/interpretation of available medical technology, and unique insights on the mechanisms of development and evolution of the nervous system.
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