Linking individual traits, the gut microbiome and parasite load in wildlife. This project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project wi ....Linking individual traits, the gut microbiome and parasite load in wildlife. This project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project will provide a new, yet crucial, perspective on how and why diseases spread. Our discoveries will help understand and manage the burden of infectious diseases from parasites in and beyond our cities and across the human-wildlife interface; essential for improving human and wildlife health in an increasingly urbanised Australia.Read moreRead less
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668026
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
The Australian Dictionary of Biography Online and Emerging National Information Systems: Networking Research Capability. The Australian Dictionary of Biography Online and Emerging National Information Systems Project will link the dictionary's scholarly biographical articles with the resources of national cultural institutions, making visible and available to researchers everywhere an unprecedented number of sources for the lives of historical actors and a much larger volume of contextual inform ....The Australian Dictionary of Biography Online and Emerging National Information Systems: Networking Research Capability. The Australian Dictionary of Biography Online and Emerging National Information Systems Project will link the dictionary's scholarly biographical articles with the resources of national cultural institutions, making visible and available to researchers everywhere an unprecedented number of sources for the lives of historical actors and a much larger volume of contextual information about them. Its leading-edge cultural informatics will make more efficient use of existing information infrastructure and stimulate further development. Researchers using the service will be enabled to make conceptual advances and produce new knowledge about Australian history and society.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452798
Funder
Australian Research Council
Funding Amount
$376,066.00
Summary
The Australian Dictionary of Biography Online: A Database of National Biography Facilitating Research into Australia's History. The project will publish the sixteen existing and all future volumes of the Australian Dictionary of Biography as a freely available relational database on the Internet. The A.D.B. is a fundamental research tool and teaching resource for Australian history, and a valuable source of knowledge about ten thousand past Australians. An innovative web-publication model will ....The Australian Dictionary of Biography Online: A Database of National Biography Facilitating Research into Australia's History. The project will publish the sixteen existing and all future volumes of the Australian Dictionary of Biography as a freely available relational database on the Internet. The A.D.B. is a fundamental research tool and teaching resource for Australian history, and a valuable source of knowledge about ten thousand past Australians. An innovative web-publication model will maximise the availability and searchability of the A.D.B., enabling researchers to pose new questions that will yield novel insights into Australian history. Interoperability with other on-line resources will result in a powerful addition to the country's information infrastructure, one capable of supporting high-quality research projects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560774
Funder
Australian Research Council
Funding Amount
$260,338.00
Summary
The Australian Dictionary of Biography Online Enhancement Project: Additional Search Capabilities and Greater Interoperability for the ADB Online. The Australian Dictionary of Biography Online Enhancement Project will augment the capabilities of the ADB Online. It will provide additional search categories and means of visualising the data in the dictionary's ten thousand biographical articles, enabling researchers to discover relationships, trends and developments, and thus to explore new them ....The Australian Dictionary of Biography Online Enhancement Project: Additional Search Capabilities and Greater Interoperability for the ADB Online. The Australian Dictionary of Biography Online Enhancement Project will augment the capabilities of the ADB Online. It will provide additional search categories and means of visualising the data in the dictionary's ten thousand biographical articles, enabling researchers to discover relationships, trends and developments, and thus to explore new themes and gain new insights into the nature of Australian history and society. The project will also develop the website's interoperability with resources provided by the National Library of Australia and other trusted institutions, making the ADB a key element in an evolving national information architecture supporting research in the humanities and social sciences.Read moreRead less
Modern human origins and early behavioural complexity in Australia and Southeast Asia. This project tackles a fundamental issue in world prehistory: how and when did humans first cross from Southeast Asia into Australia. Three new archaeological excavations using novel methods of analysis will assess the nature of behavioural complexity and human evolution at the time when Australia was first colonised over 45,000 years ago.