Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100068
Funder
Australian Research Council
Funding Amount
$931,950.00
Summary
Australian Advanced Metabolic Signal Discovery, and Imaging Platform. This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under ....Australian Advanced Metabolic Signal Discovery, and Imaging Platform. This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under environmental stress; integral chemical signals exchanged in host-microbe interactions; and volatile signatures linked to ecosystem health and developmental anomalies in animals. Results will inform innovative strategies to enhance biological adaptation, climate resilience and plant, animal, and ecosystem health.Read moreRead less
Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
Linking individual traits, the gut microbiome and parasite load in wildlife. This project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project wi ....Linking individual traits, the gut microbiome and parasite load in wildlife. This project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project will provide a new, yet crucial, perspective on how and why diseases spread. Our discoveries will help understand and manage the burden of infectious diseases from parasites in and beyond our cities and across the human-wildlife interface; essential for improving human and wildlife health in an increasingly urbanised Australia.Read moreRead less
Mobilising Dutch East India Company collections for new global stories . Australia has a rich legacy of archives, art and artefacts, including 4 shipwrecks in WA, from its history of encounters with the Dutch East India Company (VOC). Through comparative research in Australian and overseas museums and archives we aim to situate Australian collections in a global context, creating new stories about Australia as part of the VOC global network. An interdisciplinary team will train 3 ECRs and 7 HDRs ....Mobilising Dutch East India Company collections for new global stories . Australia has a rich legacy of archives, art and artefacts, including 4 shipwrecks in WA, from its history of encounters with the Dutch East India Company (VOC). Through comparative research in Australian and overseas museums and archives we aim to situate Australian collections in a global context, creating new stories about Australia as part of the VOC global network. An interdisciplinary team will train 3 ECRs and 7 HDRs and forge partnerships with the Netherlands, Britain, Denmark, Germany, Sweden, Indonesia, Malaysia, and South Africa, strengthening national capacity. Our analysis will enrich the value of collections, provide narratives for museums and sites, and revitalise content for international and domestic tourism markets.Read moreRead less
Facing new worlds: comparative histories of Australasia and North America. This project aims to develop comparative research into Indigenous and settler experiences in Australasia and North America in order to discover new connections or distinctions between the two regions for both public and academic audiences. The project will centre on a major exhibition with a focus on biography and life representation and will develop new methodologies for examining the shared or different histories of com ....Facing new worlds: comparative histories of Australasia and North America. This project aims to develop comparative research into Indigenous and settler experiences in Australasia and North America in order to discover new connections or distinctions between the two regions for both public and academic audiences. The project will centre on a major exhibition with a focus on biography and life representation and will develop new methodologies for examining the shared or different histories of complex indigenous-settler relations across "New World" sites. The expected outcomes of this project are to promote a deeper appreciation of Australia’s place in a Pacific world with as yet unexplored links to the Americas, and also to model new ways for art history and socio-cultural history to come together to explicate a shared, complicated past.Read moreRead less
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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The ABC, its Archives and its Audiences. This project aims to enable deeper understandings of the role of Australia’s principal public service broadcaster in the lives of audience members across the country, and the community needs and interests that have shaped it. The project, in partnership with the Australian Broadcasting Corporation and the National Archives of Australia, is significant because it will uncover and interpret paper records relating to listeners and viewers during the broadcas ....The ABC, its Archives and its Audiences. This project aims to enable deeper understandings of the role of Australia’s principal public service broadcaster in the lives of audience members across the country, and the community needs and interests that have shaped it. The project, in partnership with the Australian Broadcasting Corporation and the National Archives of Australia, is significant because it will uncover and interpret paper records relating to listeners and viewers during the broadcaster’s first 50 years. Expected outcomes include an enlarged and more discoverable media archive for the benefit of researchers, industry and all Australians; an innovative audience-centred approach to the ABC’s history; and enhanced academic, archival and media collaborations. Read moreRead less
Everyday Heritage. This project aims to uncover everyday but overlooked forms of Australian heritage. Working collaboratively to bridge academic and industry practice, it seeks to develop innovative methods with outcomes expected to include enhanced collaboration between heritage, digital humanities, and historical research, and new resources for communities and the heritage sector. This should provide significant social and cultural benefits such as more inclusive forms of heritage, and broader ....Everyday Heritage. This project aims to uncover everyday but overlooked forms of Australian heritage. Working collaboratively to bridge academic and industry practice, it seeks to develop innovative methods with outcomes expected to include enhanced collaboration between heritage, digital humanities, and historical research, and new resources for communities and the heritage sector. This should provide significant social and cultural benefits such as more inclusive forms of heritage, and broader intellectual and practical understandings of shared history and citizenship. The project will promote public debate on the role of the past in modern Australia through a range of new forms of history and heritage, digital resources and heritage management tools.
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Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belongin ....Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belonging’. In doing so, the project forges links between cultural studies of storytelling, LGBTIQ+ youth studies and Australian history. Benefits include innovations in reparative historical methodologies, new resources for the GLAM, youth and education sectors and improvements in LGBTIQ+ youth wellbeing.Read moreRead less