Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling w ....An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling with a novel experimental protocol to allow the study of kinetics of parasite replication in vivo. Expected outcomes will provide significant benefits, such as new avenues for vaccination and immune intervention.Read moreRead less
How a ubiquitous endosymbiont of insects protects against pathogens. The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative e ....How a ubiquitous endosymbiont of insects protects against pathogens. The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative evolutionary and genetic approaches, the project proposes to elucidate the mechanism of pathogen blocking and ascertain its broader consequences for the host. This knowledge may be critical for maintaining the effectiveness of the biocontrol approach in the field by informing the development of resistance management strategies.Read moreRead less
This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Understanding Influenza-specific T Cell Immunity In The Indigenous Population
Funder
National Health and Medical Research Council
Funding Amount
$870,112.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. T cells recognising conserved viral regions can elicit such protection. As T cells are restricted by proteins called HLAs, variable between different ethnicities, we will define T cell regions and their HLA restrictions in the Indigenous population to propose strategies for universal T cell-based protecti ....Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. T cells recognising conserved viral regions can elicit such protection. As T cells are restricted by proteins called HLAs, variable between different ethnicities, we will define T cell regions and their HLA restrictions in the Indigenous population to propose strategies for universal T cell-based protective immunity and vaccine design against influenza.Read moreRead less
The Helping Court: Examining the Early History of the Family Court of Australia. This project will benefit the many Australian families involved in divorce by analysing the process by which the Family Court of Australia, designed to reduce the acrimony and costs associated with fault-based adversarial processes, so quickly became a focus for criticism and violence. By identifying continuity and change in both the issues underlying disputes in the family law system and the strategies adopted to o ....The Helping Court: Examining the Early History of the Family Court of Australia. This project will benefit the many Australian families involved in divorce by analysing the process by which the Family Court of Australia, designed to reduce the acrimony and costs associated with fault-based adversarial processes, so quickly became a focus for criticism and violence. By identifying continuity and change in both the issues underlying disputes in the family law system and the strategies adopted to overcome them it will help to stabilise dispute resolution policies and reduce the need for review and adjustment in the future.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668026
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
The Australian Dictionary of Biography Online and Emerging National Information Systems: Networking Research Capability. The Australian Dictionary of Biography Online and Emerging National Information Systems Project will link the dictionary's scholarly biographical articles with the resources of national cultural institutions, making visible and available to researchers everywhere an unprecedented number of sources for the lives of historical actors and a much larger volume of contextual inform ....The Australian Dictionary of Biography Online and Emerging National Information Systems: Networking Research Capability. The Australian Dictionary of Biography Online and Emerging National Information Systems Project will link the dictionary's scholarly biographical articles with the resources of national cultural institutions, making visible and available to researchers everywhere an unprecedented number of sources for the lives of historical actors and a much larger volume of contextual information about them. Its leading-edge cultural informatics will make more efficient use of existing information infrastructure and stimulate further development. Researchers using the service will be enabled to make conceptual advances and produce new knowledge about Australian history and society.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452798
Funder
Australian Research Council
Funding Amount
$376,066.00
Summary
The Australian Dictionary of Biography Online: A Database of National Biography Facilitating Research into Australia's History. The project will publish the sixteen existing and all future volumes of the Australian Dictionary of Biography as a freely available relational database on the Internet. The A.D.B. is a fundamental research tool and teaching resource for Australian history, and a valuable source of knowledge about ten thousand past Australians. An innovative web-publication model will ....The Australian Dictionary of Biography Online: A Database of National Biography Facilitating Research into Australia's History. The project will publish the sixteen existing and all future volumes of the Australian Dictionary of Biography as a freely available relational database on the Internet. The A.D.B. is a fundamental research tool and teaching resource for Australian history, and a valuable source of knowledge about ten thousand past Australians. An innovative web-publication model will maximise the availability and searchability of the A.D.B., enabling researchers to pose new questions that will yield novel insights into Australian history. Interoperability with other on-line resources will result in a powerful addition to the country's information infrastructure, one capable of supporting high-quality research projects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560774
Funder
Australian Research Council
Funding Amount
$260,338.00
Summary
The Australian Dictionary of Biography Online Enhancement Project: Additional Search Capabilities and Greater Interoperability for the ADB Online. The Australian Dictionary of Biography Online Enhancement Project will augment the capabilities of the ADB Online. It will provide additional search categories and means of visualising the data in the dictionary's ten thousand biographical articles, enabling researchers to discover relationships, trends and developments, and thus to explore new them ....The Australian Dictionary of Biography Online Enhancement Project: Additional Search Capabilities and Greater Interoperability for the ADB Online. The Australian Dictionary of Biography Online Enhancement Project will augment the capabilities of the ADB Online. It will provide additional search categories and means of visualising the data in the dictionary's ten thousand biographical articles, enabling researchers to discover relationships, trends and developments, and thus to explore new themes and gain new insights into the nature of Australian history and society. The project will also develop the website's interoperability with resources provided by the National Library of Australia and other trusted institutions, making the ADB a key element in an evolving national information architecture supporting research in the humanities and social sciences.Read moreRead less