Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Trans/national activism: Organizing for Domestic Worker Rights in Southeast Asia. This project will contribute to the identified national priority, Safeguarding Australia, by providing a better understanding of the issues surrounding labour migration, including the capacity of NGOs and state governments to address the needs and rights of labour migrants in Southeast Asia. By expanding our understanding of the possibilities for democratisation within the region and contributing to theoretical dev ....Trans/national activism: Organizing for Domestic Worker Rights in Southeast Asia. This project will contribute to the identified national priority, Safeguarding Australia, by providing a better understanding of the issues surrounding labour migration, including the capacity of NGOs and state governments to address the needs and rights of labour migrants in Southeast Asia. By expanding our understanding of the possibilities for democratisation within the region and contributing to theoretical developments on the relationship between state and civil society, this research will also contribute to the national interest in influencing institutional reform and democratic transition in Asia. Read moreRead less
Comparative Border Studies. While borders are of increasing interest to Australian scholars and policy-makers, much existing research in Australia is focused on issues of border security or border integrity. There is an urgent need to supplement this work with theoretical and empirical insights drawn from the field of border studies. North America is a key site for international research in this field. Collaboration with North American scholars is thus an important step in developing and expandi ....Comparative Border Studies. While borders are of increasing interest to Australian scholars and policy-makers, much existing research in Australia is focused on issues of border security or border integrity. There is an urgent need to supplement this work with theoretical and empirical insights drawn from the field of border studies. North America is a key site for international research in this field. Collaboration with North American scholars is thus an important step in developing and expanding Australian expertise in border studies. This project will provide the intellectual environment and collaborative networks necessary to establish the first dedicated Centre for Border Studies in Australia.Read moreRead less
Shipwrecks of the Roaring Forties: a maritime archaeological reassessment of some of Australia's earliest shipwrecks. This project will evaluate new ways of investigating the history of Europeans in the Indian Ocean by using the latest technology to evaluate seven Western Australian shipwrecks excavated over 40 years ago. The project will work with emerging technologies to study these significant sites and collections.
Pearls, People, and Power: the Transformation of the Indian Ocean World. This multidisciplinary project aims to be the first transoceanic investigation of pearling in the Indian Ocean World (IOW), focusing on the Red Sea, Persian Gulf, India/Sri Lanka, Sulu Sea and northern Australia. It will use commodity-based historical analyses and object-centred biographies to undertake comparative studies of labour systems, trade networks and the cultural value of pearls/pearl shell during an era marked by ....Pearls, People, and Power: the Transformation of the Indian Ocean World. This multidisciplinary project aims to be the first transoceanic investigation of pearling in the Indian Ocean World (IOW), focusing on the Red Sea, Persian Gulf, India/Sri Lanka, Sulu Sea and northern Australia. It will use commodity-based historical analyses and object-centred biographies to undertake comparative studies of labour systems, trade networks and the cultural value of pearls/pearl shell during an era marked by the spread of European imperialism and industrialisation. The project includes historical, ethnographic and film components and is expected to produce texts, films and museum displays. It is also designed to deliver a new understanding of the IOW past, and a new appreciation of Australia's place in IOW history.Read moreRead less