Tissue Engineering the Meniscus: Combining Novel Biomimetic Hybrid Scaffolds with Adult Stem Cells. Development of a meniscal implant ex vivo will provide significant health and economic benefits, given that worldwide, millions of people annually suffer from meniscus damage or loss. We believe that a tissue engineered meniscus, composed of a novel biomimetic scaffold which guides the differentiation of mesenchymal stem cells in a novel bioreactor will provide a solution to the problem of donor ....Tissue Engineering the Meniscus: Combining Novel Biomimetic Hybrid Scaffolds with Adult Stem Cells. Development of a meniscal implant ex vivo will provide significant health and economic benefits, given that worldwide, millions of people annually suffer from meniscus damage or loss. We believe that a tissue engineered meniscus, composed of a novel biomimetic scaffold which guides the differentiation of mesenchymal stem cells in a novel bioreactor will provide a solution to the problem of donor scarcity in meniscal repair. Success in this project will lead directly to large-animal studies and clinical trials. The training of four early careeer researchers involved in this project will also be of significant benefit to the Australian Tissue Engineering and Biomaterials community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100220
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Fluorescence and internal reflection system to develop lab-on-chip devices. Fluorescence and internal reflection system to develop lab-on-chip devices:
The aim of this project is to develop and establish a state-of-the-art fluorescence imaging facility. It aims to establish a total internal reflection fluorescence microscope combined with high speed epifluorescence imaging workstation that will be tailored to specifically investigate the fundamentals of blood cell, and vascular cell function. T ....Fluorescence and internal reflection system to develop lab-on-chip devices. Fluorescence and internal reflection system to develop lab-on-chip devices:
The aim of this project is to develop and establish a state-of-the-art fluorescence imaging facility. It aims to establish a total internal reflection fluorescence microscope combined with high speed epifluorescence imaging workstation that will be tailored to specifically investigate the fundamentals of blood cell, and vascular cell function. The project forms part of a broad bioengineering research program aimed at developing novel lab-on-chip technologies for basic cell biology and haematology. Outcomes from these projects may have significant impact in fundamental research in both bioengineering and biology disciplines.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101302
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Lab-on-a-chip platforms for hemodynamics research: new approaches for the study of blood diseases. This project will use advanced microfluidic technologies to study how and why blood clotting occurs. New devices will be created that can precisely analyse the ability of blood to form clots and these will become powerful tools for the diagnosis of blood disorders and the research and validation of drugs for the treatment of these disorders.
Engineering a physiologically-relevant blood vessel in vitro . The project will develop an in vitro blood vessel model which will mimic arterial conditions by incorporating vascular cells and silk conduits as scaffolds, for the first time. This approach will overcome the limitations of simplistic 2D cell cultures, the long maturation times of fully tissue-engineered vessels, and resource intensive animal models. The innovative bioengineered construct proposed builds on the CI’s significant advan ....Engineering a physiologically-relevant blood vessel in vitro . The project will develop an in vitro blood vessel model which will mimic arterial conditions by incorporating vascular cells and silk conduits as scaffolds, for the first time. This approach will overcome the limitations of simplistic 2D cell cultures, the long maturation times of fully tissue-engineered vessels, and resource intensive animal models. The innovative bioengineered construct proposed builds on the CI’s significant advances in materials and surface engineering and the Partner Organisation’s (Codex Research) new bioreactor platform. It will offer a solution for modelling of native vessel processes in vitro that would be more appropriate for pre-clinical drug and device development, and in the long-term, tissue replacement.Read moreRead less