How Do Cross-reactive Memory B Cells Affect Influenza Vaccine Titers?
Funder
National Health and Medical Research Council
Funding Amount
$798,049.00
Summary
Influenza vaccines are updated frequently to protect against the highly variable influenza virus. Despite careful selection of vaccine viruses, most influenza vaccines provide only modest protection and protection is poor some years. In turn, the response to vaccination varies between individuals. This probably reflects complex and variable histories of influenza infection and vaccination. The project investigates how past influenza exposure influences vaccine responses and effectiveness.
Modelling The Effects Of Immunity On Influenza Transmission - Implications For Prevention And Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$275,767.00
Summary
There is uncertainty about how many people can be infected by a single person with influenza at the start of an outbreak. Some data suggest that a single generation of transmission can infect 10-20 other people. With such a rate of growth (ie 10-20 fold every 3 days) the spread of an influenza outbreak is virtually unstoppable. Other data suggest that each person with influenza infects less than 2 other people on average. With such a lower rate of growth, control would be more feasible. Our proj ....There is uncertainty about how many people can be infected by a single person with influenza at the start of an outbreak. Some data suggest that a single generation of transmission can infect 10-20 other people. With such a rate of growth (ie 10-20 fold every 3 days) the spread of an influenza outbreak is virtually unstoppable. Other data suggest that each person with influenza infects less than 2 other people on average. With such a lower rate of growth, control would be more feasible. Our project will use data from historic and contemporary outbreaks of influenza and build mathematical models to explain the rate of growth of an influenza outbreak in terms of: 1. The proportion of people exposed to influenza who do not become ill (although there can be evidence of infection if careful studies are made). This proportion is about 33%. 2. The proportion of people who are protected from influenza by immunity, whether induced by vaccination or by past exposure to natural influenza infection (this can vary from 0% in isolated populations which have not seen influenza for many years up to 80 or 90% in urbanised populations that are exposed to influenza almost every season). 3. Different rates of contact between different people and groups of people - some may be exposed so often that their immunity is boosted regularly without them becoming severely ill; others, living in more isolated circumstances, may be rarely exposed, but when they are, they are more likely to become severely ill. 4. The effects of influenza vaccine in inducing protective immunity - it is well known that there is good protection if the vaccine is well matched to the circulating virus. 5. The effects of live virus infection in inducing (short-lived) protection against a wider range of influenza viruses. Our model results will be used to guide vaccine design and pandemic planning.Read moreRead less
A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Delivering Next-Generation Broadband Internet Access to Australia: Integration of Broadband Optical and Wireless Networks. Provision of broadband services is a high priority for the Australian government as evidenced by a range of initiatives costing more than $4 billion. Especially, the integration of optical and wireless broadband access will potentially provide inexpensive and efficient solutions to customers. Building on the strength of existing photonics and wireless industries in Australia ....Delivering Next-Generation Broadband Internet Access to Australia: Integration of Broadband Optical and Wireless Networks. Provision of broadband services is a high priority for the Australian government as evidenced by a range of initiatives costing more than $4 billion. Especially, the integration of optical and wireless broadband access will potentially provide inexpensive and efficient solutions to customers. Building on the strength of existing photonics and wireless industries in Australia, direct and indirect outcomes of this project can lead to new business opportunities and will further strengthen the growing local telecommunication industries. It is also anticipated that national and international collaboration will generate further research activities and significantly enhance the existing reputation of Australian research capabilities.Read moreRead less
Enhancing Australian Universities' Research Commercialisation Performance. The primary aims of the project are to develop a detailed understanding of the systematic barriers to research commercialisation within Australian universities and to promote innovation within the commercialisation through the adoption of effective processes. The project will also explore the needs of the smaller and regional universities to develop effective strategies that will enhance their research commercialisation c ....Enhancing Australian Universities' Research Commercialisation Performance. The primary aims of the project are to develop a detailed understanding of the systematic barriers to research commercialisation within Australian universities and to promote innovation within the commercialisation through the adoption of effective processes. The project will also explore the needs of the smaller and regional universities to develop effective strategies that will enhance their research commercialisation capacity and performance through the promotion of industry uptake of their research outcomes.Read moreRead less
Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outco ....Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outcomes include new knowledge on controlling porous structures and tailoring properties to targeted applications. This project, by laying the groundwork for a new generation of bio-based materials, will benefit the Australian advanced manufacturing sector, and enhance Australia's standing in materials science and engineering.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100186
Funder
Australian Research Council
Funding Amount
$233,000.00
Summary
The 3D Nanofabrication Facility. This project aims to breach the gap between meso, micro and nanoscale manufacturing by means of a novel 3D printing technique with nanometric resolution. This project expects to generate new knowledge in the technologies to fabricate complex structures with freedom of design from the meso to the nanoscale, currently not possible in Australia, by using the innovative integration of this technique within a well establish nanofabrication facility. Expected outcomes ....The 3D Nanofabrication Facility. This project aims to breach the gap between meso, micro and nanoscale manufacturing by means of a novel 3D printing technique with nanometric resolution. This project expects to generate new knowledge in the technologies to fabricate complex structures with freedom of design from the meso to the nanoscale, currently not possible in Australia, by using the innovative integration of this technique within a well establish nanofabrication facility. Expected outcomes of this project include new discoveries in fields such as nanotechnology, photonics, robotics, metamaterials, biosurface engineering or biotechnology. This should provide significant benefits, such as placing Australia in the leadership of nanotechnology and additive manufacturing.Read moreRead less
The true potential and limitations of fibres. This project aims to understand the fibre spinning process of nanomaterials to identify their true potential and limitations in wearable applications. The project is expected to lead to multifunctional materials that allow design and production of smart functional fibres and textiles that store and convert energy and sense, monitor and respond to human activities and external environments. The project outcomes are expected to accelerate the transform ....The true potential and limitations of fibres. This project aims to understand the fibre spinning process of nanomaterials to identify their true potential and limitations in wearable applications. The project is expected to lead to multifunctional materials that allow design and production of smart functional fibres and textiles that store and convert energy and sense, monitor and respond to human activities and external environments. The project outcomes are expected to accelerate the transformation of the fibre industry, which will have far reaching implications across research disciplines and sectors critical to technology, health, social, and economic future.Read moreRead less