Genetic selection of artificial polyketides. This project aims to harness the potential of synthetic biology to build cells that can make valuable new derivatives of polyketides. Polyketides are natural products that have proven to be highly effective for use in industry, medicine and agriculture. The technologies developed in this project will provide resources to discover new chemicals, accessible to almost any scientific laboratory. Expected outcomes include the opportunity to put the future ....Genetic selection of artificial polyketides. This project aims to harness the potential of synthetic biology to build cells that can make valuable new derivatives of polyketides. Polyketides are natural products that have proven to be highly effective for use in industry, medicine and agriculture. The technologies developed in this project will provide resources to discover new chemicals, accessible to almost any scientific laboratory. Expected outcomes include the opportunity to put the future of natural product discovery and optimisation in the hands of the wider scientific community, which will provide significant benefits, such as providing new tools for Australian industries.Read moreRead less
Universal transcriptome editing technologies. Ribonucleic acid (RNA) is life’s most essential molecule – as no living cell or virus can function without it. Although RNA plays many critical roles in cells, from information transfer and regulation of gene expression to scaffolding macromolecular structures and catalysis, the current approaches to manipulate RNA for technological purposes are limited in many respects. This project brings together the scientists who were the first to discover a uni ....Universal transcriptome editing technologies. Ribonucleic acid (RNA) is life’s most essential molecule – as no living cell or virus can function without it. Although RNA plays many critical roles in cells, from information transfer and regulation of gene expression to scaffolding macromolecular structures and catalysis, the current approaches to manipulate RNA for technological purposes are limited in many respects. This project brings together the scientists who were the first to discover a universal code for recognition of RNA by proteins and one of the world’s leading RNA-focused biotechnology companies, Locana Biosciences, with the goal of providing robust and versatile tools to target RNA in diverse organisms.Read moreRead less
Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden ....Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden genomic potential of these Australian fungi. Expected outcomes of this project include new fine chemicals and lead molecules with desirable bioactivies. This will provide significant benefits to Australia's economy through the discovery of new pharmaceuticals, veterinary products and agrichemicals.Read moreRead less