Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100026
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
VetCompass: Big Data and Real-time Surveillance for Veterinary Science. VetCompass: big data and real-time surveillance for veterinary science:
The VetCompass data service intends to collect real-time records from veterinary clinics and aggregate them for researchers to interrogate. It aims to provide Australian researchers with sustainable and cost-effective access to authoritative data from hundreds of practitioners in Australia and the United Kingdom. These data will be essential for researc ....VetCompass: Big Data and Real-time Surveillance for Veterinary Science. VetCompass: big data and real-time surveillance for veterinary science:
The VetCompass data service intends to collect real-time records from veterinary clinics and aggregate them for researchers to interrogate. It aims to provide Australian researchers with sustainable and cost-effective access to authoritative data from hundreds of practitioners in Australia and the United Kingdom. These data will be essential for research on disease distribution and determinants, and surveillance and diagnostics that underpin evidence-based practice. The expected outcomes include identification of the most prevalent disorders and their causes and optimal treatments. The data may also revolutionise clinical auditing in Australia, help the veterinary profession to rank research priorities, and inform companion animal and equine curricula in our universities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100093
Funder
Australian Research Council
Funding Amount
$510,000.00
Summary
High-throughput technology targeting antimicrobial resistance in animals. This project aims to establish reference laboratories as biobanks for resistant isolate collections from veterinary diagnostic laboratories / surveillance programmes and a national research network to mitigate antimicrobial resistance in animals. Antimicrobial resistance in zoonotic/foodborne pathogens and livestock commensals is a global issue. This project will use mass-spectroscopy biotypers, information management soft ....High-throughput technology targeting antimicrobial resistance in animals. This project aims to establish reference laboratories as biobanks for resistant isolate collections from veterinary diagnostic laboratories / surveillance programmes and a national research network to mitigate antimicrobial resistance in animals. Antimicrobial resistance in zoonotic/foodborne pathogens and livestock commensals is a global issue. This project will use mass-spectroscopy biotypers, information management software, robotic liquid handling and a research dairy to develop high-throughput screening technologies to rapidly determine major animal species’ resistance status, and research anti-infectives and vaccines for livestock diseases. This will improve the health and production of Australian livestock, leading to greater market access for high quality products.Read moreRead less
Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if ....Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if the Cryptosporidium in humans is the same as that derived from water contamination sources (animals, sewage etc). The outcomes of this project will result in the development of more targeted, cost-effective preventive measures to minimize exposures to infections, accurate risk assessment, and scientific management of the watershed.Read moreRead less
Determining the impact of protozoan pathogens and strongyle worms on prime lamb production. This research will benefit wool and prime lamb industries nation-wide as sheep scouring is prevalent in high-rainfall areas across Australia. Data generated from the project will be used to educate farmers and reduce the financial burden of sheep scouring. This project will also enhance Australia's reputation in the disease management sector and will result in reduced risk to public health due to a better ....Determining the impact of protozoan pathogens and strongyle worms on prime lamb production. This research will benefit wool and prime lamb industries nation-wide as sheep scouring is prevalent in high-rainfall areas across Australia. Data generated from the project will be used to educate farmers and reduce the financial burden of sheep scouring. This project will also enhance Australia's reputation in the disease management sector and will result in reduced risk to public health due to a better understanding and management of zoonotic parasite and microbacterial contamination of carcasses and water catchments.Read moreRead less
The epidemiology of canine gastrointestinal parasitic zoonoses in different community settings in Thailand. The dog's role in transmitting zoonotic gastrointestinal parasites to humans has been recognised as a significant public health problem worldwide. Surveillance data with regard to canine parasites in Thailand and its regional countries is largely lacking, especially with regard to the dog's role as a perpetuator of the liver and intestinal flukes. This project aims to provide an accurate ....The epidemiology of canine gastrointestinal parasitic zoonoses in different community settings in Thailand. The dog's role in transmitting zoonotic gastrointestinal parasites to humans has been recognised as a significant public health problem worldwide. Surveillance data with regard to canine parasites in Thailand and its regional countries is largely lacking, especially with regard to the dog's role as a perpetuator of the liver and intestinal flukes. This project aims to provide an accurate and comprehensive assessment of the risks these parasites pose to the public using a combination of conventional and novel molecular epidemiological tools. Successful completion of this project will provide a model for control programs to be generated in the SE Asian region.Read moreRead less
Harnessing the genome of the Australian paralysis tick to develop effective control products. This project aims to examine the potent cocktail produced by the salivary gland of Australia's paralysis tick. The paralysis tick continues to cause severe illness and deaths for companion pets with up to 100,000 cases of toxicoses per year. This project aims to develop new safe treatments and/or preventative vaccines.
Immunonutrition: A novel concept to overcome gastrointestinal tract mucosal damage after weaning in pigs. A sustainable Australian pork industry relies on further reductions in costs whilst considering the enhanced health and welfare of pigs. This project will lead to more precise estimates of amino acid requirements in the post-weaning period, which will contribute to an increased efficiency of nutrient utilization and enhance the welfare of pigs recovering from the weaning process.
Exploitation of a Novel Drug Target for Controlling Animal Trypanosomiasis. Trypanosomiasis greatly reduces livestock productivity in countries where it is endemic and is a threat to livestock and native wildlife in countries such as Australia where it is exotic but there is a risk of entry. New trypanocidal drugs with different modes of action are urgently needed to overcome growing resistance. This project aims to characterise trypanosome tubulin and, with this information, produce new tubulin ....Exploitation of a Novel Drug Target for Controlling Animal Trypanosomiasis. Trypanosomiasis greatly reduces livestock productivity in countries where it is endemic and is a threat to livestock and native wildlife in countries such as Australia where it is exotic but there is a risk of entry. New trypanocidal drugs with different modes of action are urgently needed to overcome growing resistance. This project aims to characterise trypanosome tubulin and, with this information, produce new tubulin-binding compounds for assessment in vitro and in vivo. Upon completion of the project it is expected that drug binding sites on trypanosome tubulin will be characterised and at least one candidate for clinical trials identified.Read moreRead less
Developing a wildlife health intelligence and vaccine distribution system. This project aims to establish an industry-linked pipeline for vaccines to be delivered to animals in edible baits and a near real-time monitoring system for assessing the impact of management actions. This project will develop ultrasensitive diagnostic tests and incorporate biomarkers into baits from Australia's leading pest animal control company. Bait uptake and disease status in the field will be monitored using artif ....Developing a wildlife health intelligence and vaccine distribution system. This project aims to establish an industry-linked pipeline for vaccines to be delivered to animals in edible baits and a near real-time monitoring system for assessing the impact of management actions. This project will develop ultrasensitive diagnostic tests and incorporate biomarkers into baits from Australia's leading pest animal control company. Bait uptake and disease status in the field will be monitored using artificial intelligence technology developed in Tasmania. This integrated wildlife health intelligence and scalable vaccine platform can help protect the iconic Tasmanian devil from disease and increase Australia's preparedness for looming threats to the livestock industry such as African swine fever.Read moreRead less
A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent ....A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent enteric parasite identified globally in dogs. Infection rates can be as high as 75% in puppies. Current treatments are failing due to poor efficacy, resistance and poor adherence to treatment schedules. We have identified a novel, extremely rapid acting series of compounds capable of single shot eradication of Giardia.Read moreRead less