Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects. Non-steroidal anti-inflammatory drugs (NSAIDs) have widespread human and veterinary applications for the treatment of arthritis and other inflammatory diseases, but their utility is limited by often severe gastrointestinal, renal and cardiac side-effects. The recently heralded COX-2 inhibitors have not lived up to their expectations in terms of efficacy and side-effects, therefore, there is a need to develop new potent ....Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects. Non-steroidal anti-inflammatory drugs (NSAIDs) have widespread human and veterinary applications for the treatment of arthritis and other inflammatory diseases, but their utility is limited by often severe gastrointestinal, renal and cardiac side-effects. The recently heralded COX-2 inhibitors have not lived up to their expectations in terms of efficacy and side-effects, therefore, there is a need to develop new potent, but safer, NSAIDs. This project is aimed at using the results from new lead compounds to design NSAIDs with much greater efficacy and much less side effects than those currently available.Read moreRead less
Synthesis and analysis of equine anabolic steroid metabolites. The Australian Racing Industry has an annual turnover of over $11,000M and is Australia's highest employing industry. Its credibility is dependent upon the enforcement of regulations relating to illicit substances. The aim of the project is to devise testing procedures for illicit drugs in the equine. To achieve this a variety of hydroxylated anabolic steroid equine metabolites are to be synthesised as reference standards and for ....Synthesis and analysis of equine anabolic steroid metabolites. The Australian Racing Industry has an annual turnover of over $11,000M and is Australia's highest employing industry. Its credibility is dependent upon the enforcement of regulations relating to illicit substances. The aim of the project is to devise testing procedures for illicit drugs in the equine. To achieve this a variety of hydroxylated anabolic steroid equine metabolites are to be synthesised as reference standards and for studies on analytical procedures. These analytical studies will involve production of antibodies, and of the appropriate testing procedures.Read moreRead less
Novel hybrid agricultural-byproduct/synthetic materials. The French partners have developed a method of converting low-value agricultural by-products into commodity plastics; however, the results are too water-sensitive to be useful. This project is to develop the science for grafting water-resistant moieties to this product, using mechanistically-based techniques developed by the Sydney group. The outcome would be technology for making useful materials from agricultural by-products that are cur ....Novel hybrid agricultural-byproduct/synthetic materials. The French partners have developed a method of converting low-value agricultural by-products into commodity plastics; however, the results are too water-sensitive to be useful. This project is to develop the science for grafting water-resistant moieties to this product, using mechanistically-based techniques developed by the Sydney group. The outcome would be technology for making useful materials from agricultural by-products that are currently of very low value in Australia.Read moreRead less