An immunological and immunogenetic approach to understand and to protect Tasmanian devils against Devil Facial Tumour Disease. The Tasmanian devil is the world's largest living carnivorous marsupial. From an environmental perspective, devils play a fundamental role through scavenging. Dead and dying animals were removed nightly from Tasmania's landscape and therefore decaying carcases did not require removal. Loss of this top order scavenger will alter the balance of biodiversity and non-native ....An immunological and immunogenetic approach to understand and to protect Tasmanian devils against Devil Facial Tumour Disease. The Tasmanian devil is the world's largest living carnivorous marsupial. From an environmental perspective, devils play a fundamental role through scavenging. Dead and dying animals were removed nightly from Tasmania's landscape and therefore decaying carcases did not require removal. Loss of this top order scavenger will alter the balance of biodiversity and non-native animals (such as foxes, feral cats, crows, and even European wasps) will then compete for this scavenger role. As these animals are non-selective they will also prey on living animals and many of Tasmania's native animals (such as Eastern barred bandicoot, potoroos, quolls etc.) will be seriously threatened and our biodiverse landscape could be irreversibly altered.Read moreRead less
Improving the diagnosis, management and control of chlamydial infections in Australian livestock. Chlamydial diseases, such as arthritis and encephalomyelitis, are associated with significant economic losses for Australian livestock producers. Effective surveillance and management of Chlamydia infections is problematic due to: the absence of epidemiological data; the lack of an accurate and easily interpretable diagnostic test; and the lack of an available vaccine. This project aims to evaluate ....Improving the diagnosis, management and control of chlamydial infections in Australian livestock. Chlamydial diseases, such as arthritis and encephalomyelitis, are associated with significant economic losses for Australian livestock producers. Effective surveillance and management of Chlamydia infections is problematic due to: the absence of epidemiological data; the lack of an accurate and easily interpretable diagnostic test; and the lack of an available vaccine. This project aims to evaluate factors associated with chlamydial disease in Australian livestock and thereby improve on-farm diagnosis. With the concomitant development of a chlamydial vaccine for sheep, this project aims to provide veterinarians and producers with important tools to reduce the on-farm impacts of chlamydial disease.Read moreRead less
Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The ser ....Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The serological tests to be developed aim to be species-specific tests to detect the most important chlamydial sheep pathogens. This in turn endeavours to improve domestic surveillance, reducing on-farm losses and costs, and improve market opportunities for Australian sheep exporters as well as informing veterinary populations on best practice treatment.Read moreRead less
Host-tumour interplay in Tasmanian devils with devil facial tumour disease: can immune cells be harnessed for therapy? Tasmanian devils only exist naturally in Tasmania and Devil Facial Tumour Disease, an infectious cancer, could cause the extinction of the Tasmanian devil. This project will determine if Devil Facial Tumour Disease reduces the effectiveness of the devil's immune system and test if activated immune cells can protect against this disease.
Epidemiology of Phoma spp. complex and other foliar pathogens affecting pyrethrum. We will quantify the spectrum of fungal plant pathogens found on pyrethrum (Tanacetum cineariifolium L.) foliage and their relative impact on yield and pyrethrin assay. For those fungi having a significant impact on production (such as Phoma ligulicola) we will conduct detailed epidemiological studies to determine how disease levels change with environmental parameters and geographical factors. This study will a ....Epidemiology of Phoma spp. complex and other foliar pathogens affecting pyrethrum. We will quantify the spectrum of fungal plant pathogens found on pyrethrum (Tanacetum cineariifolium L.) foliage and their relative impact on yield and pyrethrin assay. For those fungi having a significant impact on production (such as Phoma ligulicola) we will conduct detailed epidemiological studies to determine how disease levels change with environmental parameters and geographical factors. This study will adapt radiometric technology for disease assessment in pyrethrum, and develop predictive models for disease development based on environmental conditions and furthermore, assess the effect of simulated climate change events on disease severity in the future.Read moreRead less
Towards a durable management strategy for ray blight in Tasmanian pyrethrum crops. This project will take a multi-factorial approach to the identification of edaphic factors and their collinearity for the prediction of foliar disease caused by the fungus, Phoma ligulicola in Tasmanian pyrethrum crops. This will allow implementation of a decision support system whereby disease management options may be weighed against site specific risk. Alternative management strategies to the current fungicid ....Towards a durable management strategy for ray blight in Tasmanian pyrethrum crops. This project will take a multi-factorial approach to the identification of edaphic factors and their collinearity for the prediction of foliar disease caused by the fungus, Phoma ligulicola in Tasmanian pyrethrum crops. This will allow implementation of a decision support system whereby disease management options may be weighed against site specific risk. Alternative management strategies to the current fungicide based system for control will also be assessed for their efficacy and role in mitigating site risk. The effect of cultural control methods such as cultivar mixtures and host resistance will be modelled on the spatio-temporal characteristics of the epidemic and compared to these in naturally occurring epidemics at specific sites.Read moreRead less
Development of an immune enhancing vaccine to protect Tasmanian devils against a contagious cancer. The iconic Tasmanian devil is threatened with extinction from a uniformly fatal transmissible facial cancer. Our team has shown in proof of concept that the cancer cells can be recognised by the devil immune system. This project will develop and test a vaccine against the tumour, which will ultimately protect devils in the wild.
Understanding the evolution of fungicide resistance for durable control of fungal pathogens in pyrethrum. The pyrethrum plant is grown for the extraction of natural insecticidal pyrethrins used in a variety of pest control products. Australia supplies 60 per cent of the global market for natural pyrethrins. Fungal pathogens of pyrethrum can cause severe losses. This project will investigate fungicide resistance in these pathogens at the molecular level.
Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala ....Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala care centres, wildlife hospitals and government departments.Read moreRead less
Meeting the challenges of Sclerotinia crown rot in a perennial production system - pyrethrum. The Australian pyrethrum industry has undergone rapid growth in the last decade, which has seen it become the second largest producer of natural insecticidal pyrethrins in the world. Current production supplies 60% of the global market, with further expansion planned. Sclerotinia crown rot is a major disease that results in plant death; reducing yields and the life of the perennial crop. This project ....Meeting the challenges of Sclerotinia crown rot in a perennial production system - pyrethrum. The Australian pyrethrum industry has undergone rapid growth in the last decade, which has seen it become the second largest producer of natural insecticidal pyrethrins in the world. Current production supplies 60% of the global market, with further expansion planned. Sclerotinia crown rot is a major disease that results in plant death; reducing yields and the life of the perennial crop. This project aims to develop more cost effective and environmentally sustainable methods of managing this disease. This will help to ensure consistent supply of pyrethrin to the world market, reduce the costs of production and increase the net return to growers.Read moreRead less