Highly integrated miniaturised total analysis systems for pharmaceuticals in biological and environmental samples. This project will develop three unique chemical approaches that will each overcome a challenge to the creation of advanced miniaturised analytical devices with sample-in/answer-out capability. This will provide substantial improvements in speed, cost, portability, and operational simplicity and safety. New technology for analysing drugs in body fluids will be critical to enabling pe ....Highly integrated miniaturised total analysis systems for pharmaceuticals in biological and environmental samples. This project will develop three unique chemical approaches that will each overcome a challenge to the creation of advanced miniaturised analytical devices with sample-in/answer-out capability. This will provide substantial improvements in speed, cost, portability, and operational simplicity and safety. New technology for analysing drugs in body fluids will be critical to enabling people to closely match their pharmaceutical consumption with their individual requirements. The advance will have implications for all patients, particularly those in remote and rural Australian populations. The same technology is likely to find applications in environmental monitoring of emerging pharmaceutical pollutants. Read moreRead less
Mitigating ecosystem impacts by improving the way we breed and manage devils. The Tasmanian ecosystem faces irreversible change due to the decline of the apex predator. An insurance population of Tasmanian devils has been established to prevent extinction of the species. Using the latest sequencing technologies the project aims to determine whether the Tasmanian ecosystem can be restored with Tasmanian devils that are more resilient to a changing environment by improving the way that devils are ....Mitigating ecosystem impacts by improving the way we breed and manage devils. The Tasmanian ecosystem faces irreversible change due to the decline of the apex predator. An insurance population of Tasmanian devils has been established to prevent extinction of the species. Using the latest sequencing technologies the project aims to determine whether the Tasmanian ecosystem can be restored with Tasmanian devils that are more resilient to a changing environment by improving the way that devils are bred and managed in captivity.Read moreRead less
Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala ....Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala care centres, wildlife hospitals and government departments.Read moreRead less
Integrating electrophysiology and molecular biology to understand the role of cell membranes in bacterial responses to chill and osmotic stress. Modern food manufacture is driven by competing demands: consumers prefer foods that are 'natural', i.e. having received minimal processing and containing less preservatives, and last, but are safe. Thus, a challenge is to find minimal sets of treatments and preservatives that limit microbial growth.
Current methods to for determining limits to microbi ....Integrating electrophysiology and molecular biology to understand the role of cell membranes in bacterial responses to chill and osmotic stress. Modern food manufacture is driven by competing demands: consumers prefer foods that are 'natural', i.e. having received minimal processing and containing less preservatives, and last, but are safe. Thus, a challenge is to find minimal sets of treatments and preservatives that limit microbial growth.
Current methods to for determining limits to microbial growth are time and consuming and empirical. We will assess the potential of a new method (MIFE) to rapidly measure limits of bacterial growth under combinations of treatments. At the same time we will study how cells, and in particular how the cell membrane, responds to these stresses to provide insights for the development of new, minimal - yet safe - food preservation technologies.
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Industrial Transformation Training Centres - Grant ID: IC140100024
Funder
Australian Research Council
Funding Amount
$2,061,605.00
Summary
ARC Training Centre for Innovative Horticultural Products. ARC Training Centre for Innovative Horticultural Products. The Australian food industry, and the fresh produce sector in particular, offers enormous opportunities for growth and diversification through development of innovative new products that are safe, convenient, affordable and healthy. The Training Centre will develop fresh foods with improved shelf life and sensory quality, through a suite of food science and market analysis projec ....ARC Training Centre for Innovative Horticultural Products. ARC Training Centre for Innovative Horticultural Products. The Australian food industry, and the fresh produce sector in particular, offers enormous opportunities for growth and diversification through development of innovative new products that are safe, convenient, affordable and healthy. The Training Centre will develop fresh foods with improved shelf life and sensory quality, through a suite of food science and market analysis projects relevant to the horticultural supply chains of Woolworths supermarket. A new model for researcher training, integrating formal course-work and workplace-integrated learning, will deliver professionals who are industry relevant, understand food product innovation and have a trans-disciplinary approach to delivering products that satisfy market demand.Read moreRead less
Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and ....Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and their consequent integration under physiological conditions. This project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community at the cutting edge of science. The project will also deliver intellectual property, which will position Australia at the forefront of bionanotechnology.Read moreRead less
Improving the diagnosis, management and control of chlamydial infections in Australian livestock. Chlamydial diseases, such as arthritis and encephalomyelitis, are associated with significant economic losses for Australian livestock producers. Effective surveillance and management of Chlamydia infections is problematic due to: the absence of epidemiological data; the lack of an accurate and easily interpretable diagnostic test; and the lack of an available vaccine. This project aims to evaluate ....Improving the diagnosis, management and control of chlamydial infections in Australian livestock. Chlamydial diseases, such as arthritis and encephalomyelitis, are associated with significant economic losses for Australian livestock producers. Effective surveillance and management of Chlamydia infections is problematic due to: the absence of epidemiological data; the lack of an accurate and easily interpretable diagnostic test; and the lack of an available vaccine. This project aims to evaluate factors associated with chlamydial disease in Australian livestock and thereby improve on-farm diagnosis. With the concomitant development of a chlamydial vaccine for sheep, this project aims to provide veterinarians and producers with important tools to reduce the on-farm impacts of chlamydial disease.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237784
Funder
Australian Research Council
Funding Amount
$707,000.00
Summary
Hyphenated Separations/Mass Spectrometry Technology for Protein and Natural Product Characterisation. This proposal consolidates the 3 institutions' collaboration on the ACROSS (Australian Centre for Research on Separation Science) initiative, providing fundamental technology for chemical structural analysis of complex samples involving high resolution protein and natural product characterisation. Requested equipment supports complete characterisation of important novel target molecules. GCxGC-T ....Hyphenated Separations/Mass Spectrometry Technology for Protein and Natural Product Characterisation. This proposal consolidates the 3 institutions' collaboration on the ACROSS (Australian Centre for Research on Separation Science) initiative, providing fundamental technology for chemical structural analysis of complex samples involving high resolution protein and natural product characterisation. Requested equipment supports complete characterisation of important novel target molecules. GCxGC-TOFMS technology will validate our newly patented multidimensional separation techniques. Q-TOF-TOFMS technology, novel patented protein prefractionation approaches, and sample handling with high resolution characterisation / identification of new target proteins allows advanced proteomics developments. Proteomics depends critically upon sophisticated MS techniques. These technologies will: ·enhance the capabilities and expertise in these sciences in the SE Australian area; ·ensure the ACROSS initiative achieves internationally competitive research capabilities; ·provide commercial endpoints in fields associated with analysis of proteins, essential oils and other natural (bio)substances.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100026
Funder
Australian Research Council
Funding Amount
$2,997,000.00
Summary
ARC Training Centre for the Australian Food Processing Industry in the 21st Century. ARC Training Centre for the Australian Food Processing Industry in the 21st Century. The Training Centre will educate a new generation of engineers and scientists and foster the capacity of Australian food industries to further develop advanced technologies in manufacturing and product improvement. The key objective is to support industry production of nutraceuticals for the promotion of health and well-being. I ....ARC Training Centre for the Australian Food Processing Industry in the 21st Century. ARC Training Centre for the Australian Food Processing Industry in the 21st Century. The Training Centre will educate a new generation of engineers and scientists and foster the capacity of Australian food industries to further develop advanced technologies in manufacturing and product improvement. The key objective is to support industry production of nutraceuticals for the promotion of health and well-being. In enabling the production of these nutraceuticals the Training Centre will design cost effective and sustainable processes that minimise waste-products, enhance efficiency and minimize the energy consumption. These high value products have enormous potential globally to boost not only partner company revenues but to significantly increase Australian exports in agribusiness.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100016
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Predictive Breeding for Agricultural Futures. This Centre aims to develop the advanced capacity needed to secure Australia’s food and fibre production and export value into the future. Leveraging immense industry support, the Centre expects to develop and integrate cutting-edge plant and animal breeding technologies and deliver world-class training that addresses critical demand for highly skilled industry leaders. Expected outcomes include a future-ready predictive breedi ....ARC Training Centre in Predictive Breeding for Agricultural Futures. This Centre aims to develop the advanced capacity needed to secure Australia’s food and fibre production and export value into the future. Leveraging immense industry support, the Centre expects to develop and integrate cutting-edge plant and animal breeding technologies and deliver world-class training that addresses critical demand for highly skilled industry leaders. Expected outcomes include a future-ready predictive breeding industry able to transform data into optimised decisions, and the human capacity to drive it. This should provide significant benefits to enhance the sustainability and profitability of all major Australian agriculture sectors, including livestock, grains, horticulture, cotton, wine, dairy, forestry and fisheries.Read moreRead less