The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Industrial Transformation Training Centres - Grant ID: IC130100005
Funder
Australian Research Council
Funding Amount
$2,405,204.00
Summary
ARC Training Centre for Innovative Wine Production. Innovative Wine Production: responding to climate, water, market and economic challenges. This Training Centre for Innovative Wine Production will provide new knowledge, methods and technologies as well as highly skilled PhD and postdoctoral researchers to tackle the main challenges for industry: Climate warming, water restrictions, changing consumer preferences and rising wine alcohol content, in order to help make the wines that consumers wan ....ARC Training Centre for Innovative Wine Production. Innovative Wine Production: responding to climate, water, market and economic challenges. This Training Centre for Innovative Wine Production will provide new knowledge, methods and technologies as well as highly skilled PhD and postdoctoral researchers to tackle the main challenges for industry: Climate warming, water restrictions, changing consumer preferences and rising wine alcohol content, in order to help make the wines that consumers want.Read moreRead less
ARC/NHMRC Research Network for Parasitology. The ARC Network for Parasitology will focus and coordinate Australia's world class fundamental, strategic and applied parasitology research. This targeted approach will raise Australia's standing in the field, assist in the community's understanding of parasitology and biosecurity and maintain and improve Australia's capacity for keeping its stock, crops, wildlife and people disease-free. On an international scale, the Network will work with other cou ....ARC/NHMRC Research Network for Parasitology. The ARC Network for Parasitology will focus and coordinate Australia's world class fundamental, strategic and applied parasitology research. This targeted approach will raise Australia's standing in the field, assist in the community's understanding of parasitology and biosecurity and maintain and improve Australia's capacity for keeping its stock, crops, wildlife and people disease-free. On an international scale, the Network will work with other countries to develop new technologies for the detection and eradication of parasites. This emphasis will not only protect Australia's borders but will assist our near neighbours and lead to the development of technologies with an economic benefit to Australia.
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Industrial Transformation Training Centres - Grant ID: IC170100008
Funder
Australian Research Council
Funding Amount
$4,459,672.00
Summary
ARC Training Centre for Innovative Wine Production. The ARC Training Centre for Innovative Wine Production aims to tackle challenges to wine production through innovative, multi-disciplinary research. Australia’s grape and wine industry is a multi-billion dollar industry, yet in some areas profitability is low. Reasons include extreme weather events, soil salinity and diseases, inefficient practices, a low level of technological innovation and high input costs. New technologies and process effic ....ARC Training Centre for Innovative Wine Production. The ARC Training Centre for Innovative Wine Production aims to tackle challenges to wine production through innovative, multi-disciplinary research. Australia’s grape and wine industry is a multi-billion dollar industry, yet in some areas profitability is low. Reasons include extreme weather events, soil salinity and diseases, inefficient practices, a low level of technological innovation and high input costs. New technologies and process efficiencies developed as part of this project will reduce environmental impact, drive production costs down and profits and employment up. The project will mount a suite of industry-led projects to deliver outcomes to boost Australia’s competitiveness as a supplier of sustainably-produced premium branded wine to the world.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100008
Funder
Australian Research Council
Funding Amount
$4,282,859.00
Summary
ARC Training Centre for Behavioural Insights for Technology Adoption (BITA). Australia needs accelerated adoption of innovation technologies to improve outcomes in health, agriculture and cybersecurity. Despite technically viable solutions, innovations fail to be adopted due to behavioural barriers. Behavioural approaches can promote significant gains by bridging the barriers to technology adoption. The Centre for Behavioural Insights for Technology Adoption will boost national productivity by i ....ARC Training Centre for Behavioural Insights for Technology Adoption (BITA). Australia needs accelerated adoption of innovation technologies to improve outcomes in health, agriculture and cybersecurity. Despite technically viable solutions, innovations fail to be adopted due to behavioural barriers. Behavioural approaches can promote significant gains by bridging the barriers to technology adoption. The Centre for Behavioural Insights for Technology Adoption will boost national productivity by identifying, designing and evaluating solutions that address these barriers. By uniting industry and government with world-leading interdisciplinary researchers, the Centre will build transformative capability in people, data and solutions and support Australian organisations to achieve higher returns on technology investment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100192
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomole ....Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomolecules including peptides, proteins and small molecules. The discovery of unknown compounds is expected to improve fundamental understanding of molecular structure and function, provide opportunities for new bio-industries in health and the environment, and generate commercial opportunities through spin-off companies, patents and licensing.Read moreRead less
ARC Centre of Excellence in Plants for Space. ARC Centre of Excellence in Plants for Space. This Centre aims to create on-demand, zero-waste, high-efficiency plants and plant products to address grand challenges in sustainability for Space and on Earth. Significant advances in plant, food, and sensory science; process and systems engineering; law and policy; and psychology are expected to deliver transformative solutions for Space habitation – and create enhanced plant-derived food and bioresour ....ARC Centre of Excellence in Plants for Space. ARC Centre of Excellence in Plants for Space. This Centre aims to create on-demand, zero-waste, high-efficiency plants and plant products to address grand challenges in sustainability for Space and on Earth. Significant advances in plant, food, and sensory science; process and systems engineering; law and policy; and psychology are expected to deliver transformative solutions for Space habitation – and create enhanced plant-derived food and bioresources to capitalise upon emergent and rapidly expanding domestic and global markets. Anticipated outcomes include industry uptake of innovative plant forms, foods, technologies, and commodities; and an ambitious education and international co-ordination agenda to position Australia as a global leader in research supporting Space habitation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100021
Funder
Australian Research Council
Funding Amount
$2,168,000.00
Summary
Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low c ....Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low cost, to address biological and biomedical research needs. This project is expected to make Australian scientists globally competitive in the life sciences including biological, clinical and biomedical, plant and crop sciences, analytical chemistry, toxicology, agriculture, wildlife conservation and sports science, and to drive advances in the data sciences for systems biology.Read moreRead less