Anthocyanin Inhibitors to the Influenza Virus. The increasing resistance of circulating influenza strains to current anti-viral inhibitors has prompted an investigation to screen, design, synthesize and evaluate a new class of natural product based inhibitors to the virus employing novel and innovative mass spectrometry, computational and structural approaches. Preliminary studies reveal they offer benefits in terms of a different mode of binding to influenza neuraminidase, remote from many know ....Anthocyanin Inhibitors to the Influenza Virus. The increasing resistance of circulating influenza strains to current anti-viral inhibitors has prompted an investigation to screen, design, synthesize and evaluate a new class of natural product based inhibitors to the virus employing novel and innovative mass spectrometry, computational and structural approaches. Preliminary studies reveal they offer benefits in terms of a different mode of binding to influenza neuraminidase, remote from many known resistance mutations, and may have specific practicality against N1 neuraminidase in H1N1 and H5N1 viruses responsible for all pandemics of the 20th and 21st centuries. The research will enable the potential of these inhibitors to be fully assessed at the molecular level for the first time.Read moreRead less
Proteotyping for the rapid identification of pandemic influenza. Future influenza pandemics will develop more rapidly providing a relatively short window with which to survey and assess the nature of the virus and administer effective treatments. Application of a new proteotyping approach will allow strains of pandemic potential to be characterised more directly and rapidly than current surveillance methods.
Predicting the evolution of the influenza virus on mass. Understanding viral reassortment is essential for the development of efficacious vaccines and to prepare for a future influenza pandemic. The research will improve our ability to monitor the evolution of reassorted influenza virus strains using new computer algorithms in concert with the application of bioinformatics and analytical technologies.
Development of electrophoretic cell sorters. The aim of this research is to develop the next generation of cell sorters to scale production of viable sperm and other cell types. Our approach is to understand the factors that control the migration of cells in an electric field so that we can design large-scale devices to purify cells using electrophoretic separation. The outcomes of this research enable large-scale production of viable sperm for human and animal-assisted conception, benefiting in ....Development of electrophoretic cell sorters. The aim of this research is to develop the next generation of cell sorters to scale production of viable sperm and other cell types. Our approach is to understand the factors that control the migration of cells in an electric field so that we can design large-scale devices to purify cells using electrophoretic separation. The outcomes of this research enable large-scale production of viable sperm for human and animal-assisted conception, benefiting infertile couples and the livestock breeding industry. Successful development of an efficient cell separation technology would add significant commercial value to the Australian biomanufacturing sector. Read moreRead less
Engineering of a novel export system for industrially important amino acids. This project aims to understand the gating mechanism of MscCG (a major amino acid exporter) and improve the amino acid production by designing a highly effective MscCG-like export system for selective membrane transport of industrially relevant amino acids. Amino acid production is one of the most promising global markets, driven by growing meat consumption in developing countries. The project aims to elucidate the thre ....Engineering of a novel export system for industrially important amino acids. This project aims to understand the gating mechanism of MscCG (a major amino acid exporter) and improve the amino acid production by designing a highly effective MscCG-like export system for selective membrane transport of industrially relevant amino acids. Amino acid production is one of the most promising global markets, driven by growing meat consumption in developing countries. The project aims to elucidate the three-dimensional structure of MscCG and identify important parts. In doing so, the project aims to design more efficient and economic amino acid production.Read moreRead less