Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable ....Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable cognitive decline that occurs in healthy aging and why some populations age less successfully than others do. Better understanding of the impact of environmental change on the biology of aging has potential community benefits.Read moreRead less
Indigenous mathematical transforms. A class of mathematical transforms, or systematic conversions between related spaces or objects, was practised by some Aboriginal and Torres Strait Islander groups. Such transforms from ground to night sky were used in long-distance route-recording and wayfinding techniques. This project aims to elucidate these transforms, and to use this knowledge to extend the mathematical framework and applications of Fourier analysis. There is significant potential for new ....Indigenous mathematical transforms. A class of mathematical transforms, or systematic conversions between related spaces or objects, was practised by some Aboriginal and Torres Strait Islander groups. Such transforms from ground to night sky were used in long-distance route-recording and wayfinding techniques. This project aims to elucidate these transforms, and to use this knowledge to extend the mathematical framework and applications of Fourier analysis. There is significant potential for new mathematics to emerge at this exciting interface of Indigenous/non-Indigenous knowledge. Expected outcomes are interdisciplinary research training for Indigenous students and new understanding of Indigenous sciences. Emerging big data technologies such as holography may benefit. Read moreRead less
#thismymob: Digital land rights and reconnecting Indigenous communities. This project aims to investigate how social technology can connect Indigenous communities and enhance wellbeing; design culturally appropriate and sensitive technologies that afford a safe refuge for Indigenous peoples and their communities. This project will design and evaluate a mobile app to implement a national-scale, Indigenous-led technology development project and develop a national technology research and developmen ....#thismymob: Digital land rights and reconnecting Indigenous communities. This project aims to investigate how social technology can connect Indigenous communities and enhance wellbeing; design culturally appropriate and sensitive technologies that afford a safe refuge for Indigenous peoples and their communities. This project will design and evaluate a mobile app to implement a national-scale, Indigenous-led technology development project and develop a national technology research and development framework and post-secondary Indigenous software engineering curricula. The project expects to benefit Indigenous developers, entrepreneurs and start-ups to develop, operate and own technology.Read moreRead less
Babera dariadya yewing (Echoes of a flawed truth): investigating theory and practice on the interplay between bullying and racism. The negative impact of bullying and racism is being increasingly documented for Aboriginal youth, yet little attempt has been made to understand the differential impact of these stressors on the wellbeing and identity of Aboriginal Australian youth. This project will seek to address this issue, to guide future action-based research.
Plant-mediated arsenic-iron mineral transformations. The project goals are to advance our understanding of molecular-level iron-arsenic transformations induced at plant-mineral-atmosphere interfaces as influenced by remediation actions and future environmental change. The project aims for this to be achieved through an innovative experimental infrastructure combined with isotopic, spectroscopic and advanced synchrotron-based tools. Intended outcomes and benefits are the generation of new knowled ....Plant-mediated arsenic-iron mineral transformations. The project goals are to advance our understanding of molecular-level iron-arsenic transformations induced at plant-mineral-atmosphere interfaces as influenced by remediation actions and future environmental change. The project aims for this to be achieved through an innovative experimental infrastructure combined with isotopic, spectroscopic and advanced synchrotron-based tools. Intended outcomes and benefits are the generation of new knowledge, which will improve current understanding of arsenic and iron fate impacted by remediation actions, plant growth and planetary changes induced via the atmosphere-plant-soil interface.Read moreRead less
Developing a predictive toxicity model for metallic anions in plants. This project aims to develop competitive anionic toxicity models for antimony, arsenic, molybdenum and selenium supported by detailed speciation information. Available ecotoxicological models for inorganic toxicants have exclusively focused on cations such as zinc, and ignored anionic toxicants such as arsenic and antimony. For available models on cations to be applicable to contaminated environments, it is essential for equiv ....Developing a predictive toxicity model for metallic anions in plants. This project aims to develop competitive anionic toxicity models for antimony, arsenic, molybdenum and selenium supported by detailed speciation information. Available ecotoxicological models for inorganic toxicants have exclusively focused on cations such as zinc, and ignored anionic toxicants such as arsenic and antimony. For available models on cations to be applicable to contaminated environments, it is essential for equivalent anionic toxicity models be developed. This project will develop the first such model, which will provide new insights on ecotoxicological modelling for inorganic anionic toxicants. The project will transform ecotoxicological modelling approaches for metals and metalloids in terrestrial systems and directly improve our ability to assess risks associated with environmental contamination.Read moreRead less
Using genetics to reconstruct the peopling and diversification of Sahul. A recent landmark study has revealed that people who first arrived on Sahul (the landmass connecting Australia with New Guinea) remained largely genetically isolated from subsequent migrations. However, there is still little known about the route(s) taken into Sahul, or how adaptation has shaped the enormous diversity now observed across Indigenous Australians and Papuans. This project aims to look at these issues by applyi ....Using genetics to reconstruct the peopling and diversification of Sahul. A recent landmark study has revealed that people who first arrived on Sahul (the landmass connecting Australia with New Guinea) remained largely genetically isolated from subsequent migrations. However, there is still little known about the route(s) taken into Sahul, or how adaptation has shaped the enormous diversity now observed across Indigenous Australians and Papuans. This project aims to look at these issues by applying phylogenetic and population genetic tools to the largest genetic dataset yet analysed from populations across Australia, New Guinea, and Island South East Asia. The outcomes of the project should reveal both the route(s) taken into Sahul and how adaptation has shaped the diversity now observed in descendants of the colonisation.Read moreRead less
Understanding the role of deep flaming in violent pyroconvective events. This project aims to improve the prediction of firestorms by combining state-of-the-art knowledge of dynamic bushfire behaviour with atmospheric models to provide a comprehensive understanding of how the heat and moisture released by a bushfire interacts with ambient atmospheric instability to produce extreme fire events. Firestorms represent the most extreme and catastrophic phase of development of a bushfire. They often c ....Understanding the role of deep flaming in violent pyroconvective events. This project aims to improve the prediction of firestorms by combining state-of-the-art knowledge of dynamic bushfire behaviour with atmospheric models to provide a comprehensive understanding of how the heat and moisture released by a bushfire interacts with ambient atmospheric instability to produce extreme fire events. Firestorms represent the most extreme and catastrophic phase of development of a bushfire. They often cause broad-scale loss of property, environmental damage and human fatalities. Firestorms cannot be suppressed, and so accurate and timely warnings of their occurrence, combined with appropriate community responses, are the only way of mitigating their effects. Better understanding of extreme fire processes may improve mitigation planning, community safety, environmental outcomes and emergency response measures.Read moreRead less
Understanding the role of terrain geometry in eruptive bushfire behaviour. This project aims to improve understanding of the physical processes that cause eruptive bushfire behaviour, otherwise known as fire blow-up. Eruptive fire behaviour, characterised by rapid and unexpected escalation in fire intensity and rate of spread, is a global phenomenon that poses a major threat to fire-fighter safety and can seriously compromise bushfire suppression efforts. This project will address the role that ....Understanding the role of terrain geometry in eruptive bushfire behaviour. This project aims to improve understanding of the physical processes that cause eruptive bushfire behaviour, otherwise known as fire blow-up. Eruptive fire behaviour, characterised by rapid and unexpected escalation in fire intensity and rate of spread, is a global phenomenon that poses a major threat to fire-fighter safety and can seriously compromise bushfire suppression efforts. This project will address the role that terrain geometry plays in the incidence of fire eruption, through consideration of its effect on the attachment of flames to a surface. Expected outcomes include a dynamic fire spread modelling framework and the provision of better advice to bushfire authorities concerning fire blow-up.Read moreRead less
Promoting positive perinatal mental health, parenting, cultural and spiritual wellbeing, and resilience in Aboriginal parents in Western Australia. With community engagement, this three year study will use existing and new data to investigate the relationships between selected indicators of perinatal mental health and positive parenting. It will promote positive perinatal mental health, parenting, cultural and spiritual wellbeing, and resilience in young Aboriginal parents in two sites in Weste ....Promoting positive perinatal mental health, parenting, cultural and spiritual wellbeing, and resilience in Aboriginal parents in Western Australia. With community engagement, this three year study will use existing and new data to investigate the relationships between selected indicators of perinatal mental health and positive parenting. It will promote positive perinatal mental health, parenting, cultural and spiritual wellbeing, and resilience in young Aboriginal parents in two sites in Western Australia.Read moreRead less