Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe t ....Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe that appears to have uniquely evolved in Australia. These results could inform the rational design of monitoring, prevention and treatment strategies to minimise infection outbreaks in Australian pigs and may result in production benefits to the pork industry, reduced environmental microbial contamination and safer food.Read moreRead less
Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less
New targets for antiviral therapies. The ability of dangerous viruses to cause lethal disease depends on their capacity to evade the immune system of infected hosts. This project will uncover at the molecular level the strategies used by viruses to disable immune responses; this will identify new ways to treat incurable diseases, by disabling the virus' defences against the immune system.
Theory and Applications of Computer-Intensive Statistical Methods. The availability of powerful computing equipment has had a dramatic impact on statistical methods and thinking. It has motivated development of novel approaches to data analysis, whose conception
and appreciation, even their application, often demand sophisticated and complex theoretical methods. In this context, the project will develop new approaches to solving non-standard statistical problems. These techniques will eithe ....Theory and Applications of Computer-Intensive Statistical Methods. The availability of powerful computing equipment has had a dramatic impact on statistical methods and thinking. It has motivated development of novel approaches to data analysis, whose conception
and appreciation, even their application, often demand sophisticated and complex theoretical methods. In this context, the project will develop new approaches to solving non-standard statistical problems. These techniques will either have direct application to solving practical problems of national or community concern, or provide a better understanding of the nature of such problems.Read moreRead less
Galactic Archaeology: A Radial Velocity Experiment to Unveil the History of the Milky Way. The ambitious RAdial Velocity Experiment (RAVE) will measure velocities and chemical properties of 50 million stars in the period 2006-2010 - 2000 times the number measured throughout history. RAVE will use a new-technology Australian fiber spectrometer at the Siding Spring UK Schmidt Telescope. A key demonstrator for RAVE is our proposed pilot survey using existing instruments to measure 100,000 stars - a ....Galactic Archaeology: A Radial Velocity Experiment to Unveil the History of the Milky Way. The ambitious RAdial Velocity Experiment (RAVE) will measure velocities and chemical properties of 50 million stars in the period 2006-2010 - 2000 times the number measured throughout history. RAVE will use a new-technology Australian fiber spectrometer at the Siding Spring UK Schmidt Telescope. A key demonstrator for RAVE is our proposed pilot survey using existing instruments to measure 100,000 stars - already 20 times larger than any previous survey - providing unique chemical and kinematical fingerprints of our Galaxy's formation. This is critical for determining the optimum observing strategy, data management, and software pipeline, before embarking on the full survey in 2006.Read moreRead less
The Last 8 Billion Years of Cosmic Evolution. A key factor in Australia's international prominence in astronomy has been the development and use of innovative instrumentation on its telescopes to undertake major leading-edge surveys. This project will enhance this reputation by using the new AAOmega facility on the 3.9m Anglo-Australian Telescope to make the largest ever survey of galaxies in the distant universe. This will allow us to address the two most important issues in cosmology today - ....The Last 8 Billion Years of Cosmic Evolution. A key factor in Australia's international prominence in astronomy has been the development and use of innovative instrumentation on its telescopes to undertake major leading-edge surveys. This project will enhance this reputation by using the new AAOmega facility on the 3.9m Anglo-Australian Telescope to make the largest ever survey of galaxies in the distant universe. This will allow us to address the two most important issues in cosmology today - the nature of the "dark energy" that is causing the universe's expansion to accelerate, and the detailed role of dark matter in galaxy formation and evolution. Read moreRead less
The fundamental physics governing the formation of cosmic structure. This project will investigate the physics that underlie three of the most fundamental processes within the universe - its accelerated expansion, the formation of cosmic structure, and galaxy formation - thereby contributing to the Priority Goal of Breakthrough Science under National Research Priority 3. It will involve world-leading research in these areas, enabled by innovative instrumentation on Australia's national telescope ....The fundamental physics governing the formation of cosmic structure. This project will investigate the physics that underlie three of the most fundamental processes within the universe - its accelerated expansion, the formation of cosmic structure, and galaxy formation - thereby contributing to the Priority Goal of Breakthrough Science under National Research Priority 3. It will involve world-leading research in these areas, enabled by innovative instrumentation on Australia's national telescope facilities. National benefit will also come via the collaborations it will involve with prestigious North American institutions. These collaborations will lead to new research capability being built within Australia, through knowledge and expertise being vested in young postgraduate and postdoctoral researchers.Read moreRead less
Large-scale three dimensional deformation of the lithosphere by subduction and mantle flow. We will be modelling of the dynamics of the Earth's crust and shallow lithosphere in response to the huge stresses created by plate motions. For Australia these stresses are transmitted from the distant plate boundaries, but they have a direct controlling influence on the evolution of the petroleum rich basins of Australia. These basins have reached maturity; further exploration will be in deep water wher ....Large-scale three dimensional deformation of the lithosphere by subduction and mantle flow. We will be modelling of the dynamics of the Earth's crust and shallow lithosphere in response to the huge stresses created by plate motions. For Australia these stresses are transmitted from the distant plate boundaries, but they have a direct controlling influence on the evolution of the petroleum rich basins of Australia. These basins have reached maturity; further exploration will be in deep water where geophysical prospecting methods are unreliable. Model-driven "exploration geodynamics" methods such as those we are developing will be needed to support traditional exploration techniques in these areas.Read moreRead less
What regulates star formation? Why does the Galaxy only make one new star per year, when it has enough material to make hundreds? This project will perform computer simulations of the slow drama unfolding in the stellar nurseries of the Milky Way, to understand what sets the rate and efficiency of star formation.
“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EA ....“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EAGLE-XL. MAGPI will deliver exquisite kinematics for hundreds of galaxies in the middle ages of the Universe, providing a view to the effect of dark matter on galaxies at this critical time, while EAGLE-XL represents the technological frontier in simulations and provides the best interpretative framework for MAGPI.Read moreRead less