Novel Babesia proteins and their roles in the pathogenesis of tick fever. This project aims at gaining a deep understanding of the biology of Babesia parasites and how they cause tick fever in cattle. The project expects to discover novel parasite proteins involved in the development and persistence of tick fever and identify their functional role in infection. The main expected outcome is the discovery of parasite proteins that are critical for infection and pathogenesis of cattle tick fever. T ....Novel Babesia proteins and their roles in the pathogenesis of tick fever. This project aims at gaining a deep understanding of the biology of Babesia parasites and how they cause tick fever in cattle. The project expects to discover novel parasite proteins involved in the development and persistence of tick fever and identify their functional role in infection. The main expected outcome is the discovery of parasite proteins that are critical for infection and pathogenesis of cattle tick fever. The findings will contribute to the development of future novel vaccines to control tick fever, with significant economic benefits for the beef and dairy industries worldwide.Read moreRead less
Bacterial and host drivers of chlamydial blindness in koalas. Chlamydial infection of the eyes is a significant cause of disease and death in koalas, contributing to the ongoing decline of this native species. Little is known about what influences the outcome of these infections, challenging efforts to manage and control koala chlamydial blindness. This project aims to evaluate whether differences in the infecting Chlamydia pecorum strains or the koala immune response, are associated with the ou ....Bacterial and host drivers of chlamydial blindness in koalas. Chlamydial infection of the eyes is a significant cause of disease and death in koalas, contributing to the ongoing decline of this native species. Little is known about what influences the outcome of these infections, challenging efforts to manage and control koala chlamydial blindness. This project aims to evaluate whether differences in the infecting Chlamydia pecorum strains or the koala immune response, are associated with the outcome of chlamydial ocular infection. In addition to helping us to understand and prevent blindness in koalas, this project should significantly expand our knowledge of the koala immune system and generate an array of koala immunological assays, outcomes that may benefit all koala conservation efforts.Read moreRead less
From the pouch to the grave: age and sex related changes in immunity in the Tasmanian devil. Tasmanian devils face extinction in the wild due to the emergence of a contagious cancer: Devil Facial Tumour Disease (DFTD). A comprehensive understanding of the devil immune system is necessary to better understand the disease and develop a vaccine against it. This project will characterise immune responses of healthy devils throughout life, from the pouch, to onset of puberty, to old age. This project ....From the pouch to the grave: age and sex related changes in immunity in the Tasmanian devil. Tasmanian devils face extinction in the wild due to the emergence of a contagious cancer: Devil Facial Tumour Disease (DFTD). A comprehensive understanding of the devil immune system is necessary to better understand the disease and develop a vaccine against it. This project will characterise immune responses of healthy devils throughout life, from the pouch, to onset of puberty, to old age. This project will then compare these responses in DFTD-affected devils to determine why DFTD affects older animals first and does not affect sexually-immature devils. Additional outcomes will include the development of novel antibiotics against human and animal diseases and an atlas of devil development using the latest imaging technologies.Read moreRead less
Skeletal endocrine signalling in the regulation of glucose metabolism. This project seeks to explore a highly novel and interesting recent development in bone biology: the fact that the skeleton is a central regulator of glucose metabolism. Currently, the mechanisms involved in this process remain unclear. mTORC1 has been identified as a signalling pathway in bone cells that modulates glucose metabolism. This project plans to selectively delete mTORC1 in the bone cells of mice to examine how ske ....Skeletal endocrine signalling in the regulation of glucose metabolism. This project seeks to explore a highly novel and interesting recent development in bone biology: the fact that the skeleton is a central regulator of glucose metabolism. Currently, the mechanisms involved in this process remain unclear. mTORC1 has been identified as a signalling pathway in bone cells that modulates glucose metabolism. This project plans to selectively delete mTORC1 in the bone cells of mice to examine how skeletal mTORC1 signalling regulates glucose metabolism, and identify novel pathways and circulating factors involved in this process. These studies may provide greater understanding of the basic biology of glucose metabolism, and may have applications in animal husbandry and the future management of diabetes.Read moreRead less
Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understandin ....Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understanding of mammalian reproduction. The knowledge gained will have application in captive breeding and conservation of these extraordinary Australian mammals. The project also provides opportunity to train research students in cutting edge molecular biology and informatics.Read moreRead less
Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The cur ....Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The curation of genomic and transcriptomic data sets, and elucidation of snail–parasite interactions will underpin the development of environmental diagnostic tests and deliver a new generation of intervention strategies to reduce the burden of liver fluke disease through the control of their snail intermediate hosts.Read moreRead less
The High Time Resolution Radio Universe. The radio sky is blanketed by charged particles in the interstellar medium that smear impulsive emissions. By constructing a new digital electronic device for the giant Parkes radio telescope we will be able to divide the radio sky up into many thousands of radio "channels", which when searched on a supercomputer, will enable us to peer into the heart of our Galaxy in search of short bursts of emission. This will be the first large-scale search of the Uni ....The High Time Resolution Radio Universe. The radio sky is blanketed by charged particles in the interstellar medium that smear impulsive emissions. By constructing a new digital electronic device for the giant Parkes radio telescope we will be able to divide the radio sky up into many thousands of radio "channels", which when searched on a supercomputer, will enable us to peer into the heart of our Galaxy in search of short bursts of emission. This will be the first large-scale search of the Universe for short bursts of radio emission. The project will pioneer real-time processing of data on a remote supercomputer via a dedicated fibre link. Read moreRead less
The Commonwealth Cosmology Initiative: From the First Objects to the Cosmic Web. The Commonwealth Cosmology Initiative (CCI) is an exciting development for Australian astronomy's gifted young High Performance Computational (HPC) Astrophysics community. The CCI links the efforts of Australia's next-generation of HPC and theoretical cosmologists with those of the leading scientists in the world. The CCI will provide unparalleled opportunities to Australia's postgraduate and Early Career Research ....The Commonwealth Cosmology Initiative: From the First Objects to the Cosmic Web. The Commonwealth Cosmology Initiative (CCI) is an exciting development for Australian astronomy's gifted young High Performance Computational (HPC) Astrophysics community. The CCI links the efforts of Australia's next-generation of HPC and theoretical cosmologists with those of the leading scientists in the world. The CCI will provide unparalleled opportunities to Australia's postgraduate and Early Career Researcher community to take part in a program of research designed to answer several of the fundamental mysteries of modern astronomy - the formation of galaxies, their relationship with Cosmic Web in which they are embedded, and the nature of dark matter.Read moreRead less
Galactic Archaeology: A Radial Velocity Experiment to Unveil the History of the Milky Way. The ambitious RAdial Velocity Experiment (RAVE) will measure velocities and chemical properties of 50 million stars in the period 2006-2010 - 2000 times the number measured throughout history. RAVE will use a new-technology Australian fiber spectrometer at the Siding Spring UK Schmidt Telescope. A key demonstrator for RAVE is our proposed pilot survey using existing instruments to measure 100,000 stars - a ....Galactic Archaeology: A Radial Velocity Experiment to Unveil the History of the Milky Way. The ambitious RAdial Velocity Experiment (RAVE) will measure velocities and chemical properties of 50 million stars in the period 2006-2010 - 2000 times the number measured throughout history. RAVE will use a new-technology Australian fiber spectrometer at the Siding Spring UK Schmidt Telescope. A key demonstrator for RAVE is our proposed pilot survey using existing instruments to measure 100,000 stars - already 20 times larger than any previous survey - providing unique chemical and kinematical fingerprints of our Galaxy's formation. This is critical for determining the optimum observing strategy, data management, and software pipeline, before embarking on the full survey in 2006.Read moreRead less
The Last 8 Billion Years of Cosmic Evolution. A key factor in Australia's international prominence in astronomy has been the development and use of innovative instrumentation on its telescopes to undertake major leading-edge surveys. This project will enhance this reputation by using the new AAOmega facility on the 3.9m Anglo-Australian Telescope to make the largest ever survey of galaxies in the distant universe. This will allow us to address the two most important issues in cosmology today - ....The Last 8 Billion Years of Cosmic Evolution. A key factor in Australia's international prominence in astronomy has been the development and use of innovative instrumentation on its telescopes to undertake major leading-edge surveys. This project will enhance this reputation by using the new AAOmega facility on the 3.9m Anglo-Australian Telescope to make the largest ever survey of galaxies in the distant universe. This will allow us to address the two most important issues in cosmology today - the nature of the "dark energy" that is causing the universe's expansion to accelerate, and the detailed role of dark matter in galaxy formation and evolution. Read moreRead less