Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe t ....Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe that appears to have uniquely evolved in Australia. These results could inform the rational design of monitoring, prevention and treatment strategies to minimise infection outbreaks in Australian pigs and may result in production benefits to the pork industry, reduced environmental microbial contamination and safer food.Read moreRead less
Decoding germination defects that threaten global wheat production. Wheat is a major commodity in Australia. Sprouting damage represents a major global threat to wheat production and food security. This project will explore the genetic and molecular mechanisms underpinning pre-harvest sprouting (PHS) and late-maturity amylase (LMA). This project will apply transcriptomics and proteomics to measure the expression of the biomolecules associated with PHS and LMA, generating fundamental knowledge of ....Decoding germination defects that threaten global wheat production. Wheat is a major commodity in Australia. Sprouting damage represents a major global threat to wheat production and food security. This project will explore the genetic and molecular mechanisms underpinning pre-harvest sprouting (PHS) and late-maturity amylase (LMA). This project will apply transcriptomics and proteomics to measure the expression of the biomolecules associated with PHS and LMA, generating fundamental knowledge of grain molecular physiology that addresses a significant knowledge gap. The project will deliver tools capable of differentiating these conditions, thereby minimising economic losses. A better understanding of the genetic basis of PHS and LMA will lay the foundation for advanced breeding aiming to eliminate these. Read moreRead less
“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EA ....“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EAGLE-XL. MAGPI will deliver exquisite kinematics for hundreds of galaxies in the middle ages of the Universe, providing a view to the effect of dark matter on galaxies at this critical time, while EAGLE-XL represents the technological frontier in simulations and provides the best interpretative framework for MAGPI.Read moreRead less
Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid i ....Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid in developing and designing artificial tactile sensors inspired by their biological models studied in this project. Long-term, the project is expected to make an original contribution towards developing new technologies and novel medical applications, both of which promise to be of great national benefit.Read moreRead less
The evolution of mass and energy over the past 13 billion years. The universe has slowly transformed atomic material into a range of structures from planets, stars, galaxies, clusters and filaments. In the process the universe has generated energy at almost all wavelengths. This project will build a model to explain the evolution of mass, energy and structure in the universe and will test the model using the latest data.
Utilising artificial intelligence to elucidate the physics of galaxies. For decades astronomers have puzzled over the connection between the structure and evolution of galaxies and the role played by host environments. This project aims to resolve this problem by combining multi-wavelength observations, multi-component simulations, and pioneering data analysis using artificial intelligence. In particular, we target the nearby Fornax galaxy cluster as a laboratory for studying galaxy formation in ....Utilising artificial intelligence to elucidate the physics of galaxies. For decades astronomers have puzzled over the connection between the structure and evolution of galaxies and the role played by host environments. This project aims to resolve this problem by combining multi-wavelength observations, multi-component simulations, and pioneering data analysis using artificial intelligence. In particular, we target the nearby Fornax galaxy cluster as a laboratory for studying galaxy formation in dense environments. Using our novel machine learning techniques, we will elucidate the physical mechanisms that drive the rapid evolution of star formation, galactic nuclei, and gas and dust content within Fornax. Our predictions will benefit ongoing and future surveys at the national and international level. Read moreRead less
Origin of jaws - the greatest unsolved mystery of early vertebrate evolution. The 2008 discovery of an unborn embryo in the 380 million-year-old "Mother Fish" from the famous Gogo fossil deposit in NW Australia has attracted a collaboration of Australian, American and Chinese scientists to a new international collaboration. The team will study spectacular new fossils from central Australia and southern China, the oldest known back-boned animals with jaws and a hard skeleton. Innovative 3D X-ray ....Origin of jaws - the greatest unsolved mystery of early vertebrate evolution. The 2008 discovery of an unborn embryo in the 380 million-year-old "Mother Fish" from the famous Gogo fossil deposit in NW Australia has attracted a collaboration of Australian, American and Chinese scientists to a new international collaboration. The team will study spectacular new fossils from central Australia and southern China, the oldest known back-boned animals with jaws and a hard skeleton. Innovative 3D X-ray computer tomography, and the Australian synchrotron, will be used to investigate ancient cells and preserved soft tissue structures, to search for evidence that copulation and internal fertilization, as in modern mammals, might have originated when jaws first evolved. Read moreRead less
How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at ....How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at improving educational outcomes or counteracting age-related memory decline. Potential future benefits include facilitating the development of drugs to circumvent memory loss resulting from brain diseases, and improving the design of neuromorphic hardware for computing.Read moreRead less
Solving the mystery of ultra luminous fast radio burst emission . Fast Radio Bursts are a recently discovered inexplicable astronomical phenomenon whose millisecond-timescale emission is generated by regions less than 300 kilometres across yet so luminous it is visible at cosmological distances. Using the Australian Square Kilometre Array Pathfinder we have already localised these bursts, which made the front cover of Science, and recently used them to find the missing baryonic matter in the Uni ....Solving the mystery of ultra luminous fast radio burst emission . Fast Radio Bursts are a recently discovered inexplicable astronomical phenomenon whose millisecond-timescale emission is generated by regions less than 300 kilometres across yet so luminous it is visible at cosmological distances. Using the Australian Square Kilometre Array Pathfinder we have already localised these bursts, which made the front cover of Science, and recently used them to find the missing baryonic matter in the Universe. Next, we will scrutinise these bursts at three nanosecond time resolution, reaching the timescale necessary to probe the mechanism by which their ultra-luminous radiation is generated. This project will reveal previously inaccessible properties of the radiation to unlock the secrets of how they are produced.Read moreRead less
Weighing the Universe using fast radio bursts. Fast radio bursts are a newly-discovered astronomical phenomenon whose millisecond-timescale emission occurs at cosmological distances, rendering them exceptional probes of the matter that lies in intergalactic space. This project aims to measure the positions and obtain the distances to these bursts to make a direct measurement of the density of ordinary matter in the Universe, at least 50 per cent of which is believed to remain undetected in inter ....Weighing the Universe using fast radio bursts. Fast radio bursts are a newly-discovered astronomical phenomenon whose millisecond-timescale emission occurs at cosmological distances, rendering them exceptional probes of the matter that lies in intergalactic space. This project aims to measure the positions and obtain the distances to these bursts to make a direct measurement of the density of ordinary matter in the Universe, at least 50 per cent of which is believed to remain undetected in intergalactic space. This project will measure the distribution of this missing matter, and find how it has evolved throughout the history of the Universe. This will provide significant benefits, such as addressing two fundamental questions about our Universe: how much matter does it contain, and has a large fraction of it hitherto evaded detection in intergalactic space?Read moreRead less