Exploitation of a Novel Drug Target for Controlling Animal Trypanosomiasis. Trypanosomiasis greatly reduces livestock productivity in countries where it is endemic and is a threat to livestock and native wildlife in countries such as Australia where it is exotic but there is a risk of entry. New trypanocidal drugs with different modes of action are urgently needed to overcome growing resistance. This project aims to characterise trypanosome tubulin and, with this information, produce new tubulin ....Exploitation of a Novel Drug Target for Controlling Animal Trypanosomiasis. Trypanosomiasis greatly reduces livestock productivity in countries where it is endemic and is a threat to livestock and native wildlife in countries such as Australia where it is exotic but there is a risk of entry. New trypanocidal drugs with different modes of action are urgently needed to overcome growing resistance. This project aims to characterise trypanosome tubulin and, with this information, produce new tubulin-binding compounds for assessment in vitro and in vivo. Upon completion of the project it is expected that drug binding sites on trypanosome tubulin will be characterised and at least one candidate for clinical trials identified.Read moreRead less
A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent ....A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent enteric parasite identified globally in dogs. Infection rates can be as high as 75% in puppies. Current treatments are failing due to poor efficacy, resistance and poor adherence to treatment schedules. We have identified a novel, extremely rapid acting series of compounds capable of single shot eradication of Giardia.Read moreRead less
Developing a wildlife health intelligence and vaccine distribution system. This project aims to establish an industry-linked pipeline for vaccines to be delivered to animals in edible baits and a near real-time monitoring system for assessing the impact of management actions. This project will develop ultrasensitive diagnostic tests and incorporate biomarkers into baits from Australia's leading pest animal control company. Bait uptake and disease status in the field will be monitored using artif ....Developing a wildlife health intelligence and vaccine distribution system. This project aims to establish an industry-linked pipeline for vaccines to be delivered to animals in edible baits and a near real-time monitoring system for assessing the impact of management actions. This project will develop ultrasensitive diagnostic tests and incorporate biomarkers into baits from Australia's leading pest animal control company. Bait uptake and disease status in the field will be monitored using artificial intelligence technology developed in Tasmania. This integrated wildlife health intelligence and scalable vaccine platform can help protect the iconic Tasmanian devil from disease and increase Australia's preparedness for looming threats to the livestock industry such as African swine fever.Read moreRead less
Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if ....Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if the Cryptosporidium in humans is the same as that derived from water contamination sources (animals, sewage etc). The outcomes of this project will result in the development of more targeted, cost-effective preventive measures to minimize exposures to infections, accurate risk assessment, and scientific management of the watershed.Read moreRead less
Rational design of new drug candidates for the treatment of Trypanosoma cruzi infection. There is a serious shortage of safe and effective drugs to treat Chagas disease which is caused by a parasitic infection. This project aims to design and identify new drug candidates by defining the disposition profile within the body which is necessary to achieve a therapeutic effect.
Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less
Developing solutions to marine mammal interactions with long-line fisheries. Developing solutions to marine mammal interactions with long-line fisheries. This project aims to use innovative techniques to determine aspects of natural marine mammal behaviour that can be exploited, in conjunction with optimal fishing vessel operations, to minimise their interactions with commercial fisheries. Marine mammal interactions with commercial fisheries are a growing worldwide issue with both ecological (in ....Developing solutions to marine mammal interactions with long-line fisheries. Developing solutions to marine mammal interactions with long-line fisheries. This project aims to use innovative techniques to determine aspects of natural marine mammal behaviour that can be exploited, in conjunction with optimal fishing vessel operations, to minimise their interactions with commercial fisheries. Marine mammal interactions with commercial fisheries are a growing worldwide issue with both ecological (incidental bycatch and increased dependence on fisheries) and economic consequences (annual losses of tens of millions of dollars to the fishing industry). Successful solutions to reduce these interactions have remained elusive. Outcomes from this research are expected to be applicable worldwide, have substantial economic and ecological benefits, and ensure the sustainability of the fishing industry.Read moreRead less
Monitoring and Modelling Hydrogeochemical Interactions with Groundwater : Implications for Mine Dewatering on Groundwater, River and Lake Chemistry. Alcoa operates a power station and brown coal mine at Anglesea in western Victoria. Following heavy rain in 2000 acidic water entered the Anglesea estuary causing precipitation of iron and aluminium flocs and fish kills. Estuary closure to tourism resulted. This project will identify the cause(s) of this phenomenon by modelling groundwater movement ....Monitoring and Modelling Hydrogeochemical Interactions with Groundwater : Implications for Mine Dewatering on Groundwater, River and Lake Chemistry. Alcoa operates a power station and brown coal mine at Anglesea in western Victoria. Following heavy rain in 2000 acidic water entered the Anglesea estuary causing precipitation of iron and aluminium flocs and fish kills. Estuary closure to tourism resulted. This project will identify the cause(s) of this phenomenon by modelling groundwater movement and studying geochemical processes. The resultant hydrogeochemical model will also be applied to simulating longer term water quality changes in the catchment arising from current mine dewatering operations and future rewatering following mine closure.
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Creating perceptual experts in Australia's policing and security agencies. This project aims to create the next generation of experts in Australia’s policing and national security agencies, by improving crime scene evidence interpretation. Agencies are under pressure to develop more rigorous training practices that go beyond mere intuition and tradition. This project will use a novel approach that directs learning toward the most diagnostic perceptual cues. Expected outcomes include a solid empi ....Creating perceptual experts in Australia's policing and security agencies. This project aims to create the next generation of experts in Australia’s policing and national security agencies, by improving crime scene evidence interpretation. Agencies are under pressure to develop more rigorous training practices that go beyond mere intuition and tradition. This project will use a novel approach that directs learning toward the most diagnostic perceptual cues. Expected outcomes include a solid empirical basis for national training programs designed to create experts that are accurate, reliable, and continuously improving. Improving the training of experts will ensure the integrity of forensics as evidentiary tools available to police, lead to more reliable courtroom convictions and help safeguard Australia from terrorism and crime.Read moreRead less
Fire management of complex rehabilitated forests - quantifying and understanding spatial variability of forest structure and fuels. Up to 5 million ha of forest is burnt by bushfire in Australia in severe fire years. The cost of fire suppression in 2002/3 in WA was in excess of 12 million dollars. Consequently, development and application of technologies and knowledge for enhancing fire management and reducing wildfire risk is of high priority and substantial economic, social and environmental b ....Fire management of complex rehabilitated forests - quantifying and understanding spatial variability of forest structure and fuels. Up to 5 million ha of forest is burnt by bushfire in Australia in severe fire years. The cost of fire suppression in 2002/3 in WA was in excess of 12 million dollars. Consequently, development and application of technologies and knowledge for enhancing fire management and reducing wildfire risk is of high priority and substantial economic, social and environmental benefit. The opportunity to conduct experimental fires across a complex landscape will enable calibration and development of technologies not previously possible. This research will define the way prescribed fire is used to integrate young rehabilitated forest into management of the broader landscape and develop more cost-effective tools for fire management.Read moreRead less