Nanobionic sensors for Real-Time Plant Health Monitoring. This project aims to develop nanosensors to detect and monitor plant health in real-time by measuring stress molecules. The project will create new knowledge on functional materials with unique optical, electronic and thermal properties as well as their bio-nano interactions with plants. The expected outcomes of the project will provide insight into 1) how localised nanosensors target organelles in living plants to 2) generate signals tha ....Nanobionic sensors for Real-Time Plant Health Monitoring. This project aims to develop nanosensors to detect and monitor plant health in real-time by measuring stress molecules. The project will create new knowledge on functional materials with unique optical, electronic and thermal properties as well as their bio-nano interactions with plants. The expected outcomes of the project will provide insight into 1) how localised nanosensors target organelles in living plants to 2) generate signals that can be picked up by portable devices to 3) report on plant health. Functional nanosensors will enable smart farming, precision agriculture and contribute to future agronomic research, further strengthening Australia’s position as an international leader in nanobiotechnology.Read moreRead less
Orientated biointerfacing of cell-mimetic nanoparticles. The project aims to create next-generation cell-mimetic nanotechnology by providing in-depth understandings and precise control over cell membrane coating orientation of biomimetic nanoparticles. Our approach is to design and develop new synthetic and analytic strategies to construct and quantify orientated biointerfacing. This will generate new knowledge and patentable methodologies related to orientated biomimetic nanoparticles. Expected ....Orientated biointerfacing of cell-mimetic nanoparticles. The project aims to create next-generation cell-mimetic nanotechnology by providing in-depth understandings and precise control over cell membrane coating orientation of biomimetic nanoparticles. Our approach is to design and develop new synthetic and analytic strategies to construct and quantify orientated biointerfacing. This will generate new knowledge and patentable methodologies related to orientated biomimetic nanoparticles. Expected outcomes include significant contributions to Australia's scholarly outputs, enhanced national capacity in disruptive nanotechnology, new opportunities for national value-add material manufacturing, and long-term benefits to biomedical and veterinary industries through new materials and nanotechnologies.
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Diamane: A New Frontier in Materials Science. Single-layer diamond (‘diamane’) is a new frontier of material research although its preparation is still in infancy with many structures predicted possible but have not been made experimentally. Built on a new chemical route for 'graphite to diamane' transformation, this project will address a research gap towards synthesising new diamane(-like) nanostructures and developing an in-depth understanding of the chemically induced phase transformation an ....Diamane: A New Frontier in Materials Science. Single-layer diamond (‘diamane’) is a new frontier of material research although its preparation is still in infancy with many structures predicted possible but have not been made experimentally. Built on a new chemical route for 'graphite to diamane' transformation, this project will address a research gap towards synthesising new diamane(-like) nanostructures and developing an in-depth understanding of the chemically induced phase transformation and structure-property correlations, which will have far-reaching impact on scientific fields beyond carbon research. Preliminary data points to both feasibility and impact for discovering new materials and technologies, which will bring foreseeable scholarly, economic, and social benefits.Read moreRead less
Nanoengineered hybrid coatings that control inflammation to artificial bone. This project aims to develop novel biocompatible surfaces using nanotechnology approaches to understand how cells attach to and grow on artificial bone materials. This research is significant because it combines novel nanofabrication and surface modification strategies for unprecedented control and manipulation of inflammatory cell behaviour relevant to orthopaedic implants. The project will overcome current limitations ....Nanoengineered hybrid coatings that control inflammation to artificial bone. This project aims to develop novel biocompatible surfaces using nanotechnology approaches to understand how cells attach to and grow on artificial bone materials. This research is significant because it combines novel nanofabrication and surface modification strategies for unprecedented control and manipulation of inflammatory cell behaviour relevant to orthopaedic implants. The project will overcome current limitations of uncontrollable inflammatory reactions to surfaces. The multifunctional surfaces are expected to give the biomaterials field new tools to control and maintain bone cell functionality, in vitro. Potential long-term benefits include applications as coatings in tissue engineering, regenerative medicine, and medical implants.Read moreRead less
Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestio ....Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestion and thermal stress. This will be achieved by tailoring the nanochemistry at multi-scales. Expected outcomes include new knowledge in custom-design of functional nanomaterials for mRNA delivery, and new technology that will bring commercial benefits to the partner organisation and the biopharma sector.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100086
Funder
Australian Research Council
Funding Amount
$510,000.00
Summary
Integrated multimodal microscopy facility for single molecule analysis. This project aims to establish an integrated multimodal microscopy facility in Australia for extensive structural characterization of functional and biological materials at the nanoscale and single molecule level. Discoveries using the facility will provide new insights into the relationship between molecules, materials, and their functions. The key outcomes and benefits of this facility are to i) strengthen the research eff ....Integrated multimodal microscopy facility for single molecule analysis. This project aims to establish an integrated multimodal microscopy facility in Australia for extensive structural characterization of functional and biological materials at the nanoscale and single molecule level. Discoveries using the facility will provide new insights into the relationship between molecules, materials, and their functions. The key outcomes and benefits of this facility are to i) strengthen the research effort in materials science and biotechnology, ii) advance the development of functional materials for biosensing and energy storage, and iii) create new catalysts for green energy conversion. The funding will ensure researchers have access to the latest technology critical to maintaining world-class research.Read moreRead less
Engineering Functional Antimicrobial Polypeptide Surfaces. Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims ....Engineering Functional Antimicrobial Polypeptide Surfaces. Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims to exploit the adhesive nature of metal–phenolic materials to rapidly coat diverse surfaces, including stainless steel and textiles. The expected outcome is the generation of antimicrobial polypeptide surfaces, which will have benefits in food safety, medical implant technology and advanced textiles.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100259
Funder
Australian Research Council
Funding Amount
$445,437.00
Summary
Next Generation Mass Spectrometry for Single-Cell Metabolomics. Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed ....Next Generation Mass Spectrometry for Single-Cell Metabolomics. Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed nanostructure to enhance detection efficiency. Expected outcomes include the development of a revolutionary carbon assisted NIMS platform for single-cell metabolomics analysis, and valuable intellectual property of commercial interest to provide economic benefit to Australia through technology advancement.Read moreRead less
Design of 2D Soft Plasmonic Photocatalysts for Artificial Leaves. The project aims to fabricate 2D soft plasmonic photocatalysts with leaf-like structures and functions for solar-to chemical energy conversions. The proposed 2D photocatalysts expect to change the traditional way of designing artificial photocatalysts. Expected outcomes of this project include fabrication of 2D soft plasmonic photocatalyst with large-area, ultrathin thickness, and high flexibility, understanding their plasmon-enha ....Design of 2D Soft Plasmonic Photocatalysts for Artificial Leaves. The project aims to fabricate 2D soft plasmonic photocatalysts with leaf-like structures and functions for solar-to chemical energy conversions. The proposed 2D photocatalysts expect to change the traditional way of designing artificial photocatalysts. Expected outcomes of this project include fabrication of 2D soft plasmonic photocatalyst with large-area, ultrathin thickness, and high flexibility, understanding their plasmon-enhanced photocatalysis mechanisms, and construction of artificial leaves to perform the solar-to-chemical conversions, which can provide significant benefits, such as creating new-generation of soft energy devices and advancing Australian expertise in photochemistry, self-assembly, and functional nanomaterials.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100032
Funder
Australian Research Council
Funding Amount
$456,547.00
Summary
Chemical and structural design for high power energy storage materials. This project aims to develop new materials with both high power and high energy storage capabilities by exploring emerging relaxor antiferroelectric (RAFE) materials. Through investigating the internal chemical and structural factors, and their interactions at different length scales, this project will first solve the current ambiguities in RAFEs and then identify critical factors for properties to better design and develop ....Chemical and structural design for high power energy storage materials. This project aims to develop new materials with both high power and high energy storage capabilities by exploring emerging relaxor antiferroelectric (RAFE) materials. Through investigating the internal chemical and structural factors, and their interactions at different length scales, this project will first solve the current ambiguities in RAFEs and then identify critical factors for properties to better design and develop new high-performance energy storage materials. The outcomes of this project will advance the knowledge of ferroic materials, provide new candidates for advanced electrical systems such as renewable energy, electric vehicles and pulsed power devices, and potentially revolutionise high power energy storage technologies.Read moreRead less