Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals. The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These c ....Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals. The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These cells cannot divide and so when this store is exhausted, reproduction ceases. Our strategy is to develop pharmaceutical reagents that will destroy this dormant egg population, thereby rendering the animals instantaneously and irreversibly infertile.Read moreRead less
Health and sustainability: Australia in a global context. Sustainable population health in Australia is threatened by emerging global and domestic forces, including rising costs of energy and food, linked with climate change and migration. Domestic factors include a growing, ageing population. Better understanding of these forces will enhance national capacity to respond and adapt to these risks.
An evaluation of novel aluminosilicate materials based on modified kaolins for environmental applications. We have shown that simple and inexpensive modification of kaolin produces materials that adsorb large amounts of ammonium (N) and phosphate (P). We intend to evaluate and develop these materials for water treatment, so as to reduce N, P inputs into rivers and wetlands. The materials can then be used as fertilisers. Similarly addition of the materials to sandy soils to reduce leaching losses ....An evaluation of novel aluminosilicate materials based on modified kaolins for environmental applications. We have shown that simple and inexpensive modification of kaolin produces materials that adsorb large amounts of ammonium (N) and phosphate (P). We intend to evaluate and develop these materials for water treatment, so as to reduce N, P inputs into rivers and wetlands. The materials can then be used as fertilisers. Similarly addition of the materials to sandy soils to reduce leaching losses of N, P from fertilisers will be investigated. The major outcome of this research will be effective and inexpensive procedures for reducing eutrophication due to N, P from waste water and fertilisers.Read moreRead less
Mitigating ecosystem impacts by improving the way we breed and manage devils. The Tasmanian ecosystem faces irreversible change due to the decline of the apex predator. An insurance population of Tasmanian devils has been established to prevent extinction of the species. Using the latest sequencing technologies the project aims to determine whether the Tasmanian ecosystem can be restored with Tasmanian devils that are more resilient to a changing environment by improving the way that devils are ....Mitigating ecosystem impacts by improving the way we breed and manage devils. The Tasmanian ecosystem faces irreversible change due to the decline of the apex predator. An insurance population of Tasmanian devils has been established to prevent extinction of the species. Using the latest sequencing technologies the project aims to determine whether the Tasmanian ecosystem can be restored with Tasmanian devils that are more resilient to a changing environment by improving the way that devils are bred and managed in captivity.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100021
Funder
Australian Research Council
Funding Amount
$2,168,000.00
Summary
Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low c ....Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low cost, to address biological and biomedical research needs. This project is expected to make Australian scientists globally competitive in the life sciences including biological, clinical and biomedical, plant and crop sciences, analytical chemistry, toxicology, agriculture, wildlife conservation and sports science, and to drive advances in the data sciences for systems biology.Read moreRead less
Special Research Initiatives - Grant ID: SR0354605
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Earth System Dynamics Network for a Sustainable Australia. Earth comprises systems of enormous complexity that sustain all life and control the distribution of mineral, energy and water resources. Thus understanding these dynamic systems provides the key to sustainable resource usage. The aim of The Earth System Dynamics Network is to facilitate scientific interactions through establishment of an earth and environmental sciences grid that links national and regional data assets with high per ....The Earth System Dynamics Network for a Sustainable Australia. Earth comprises systems of enormous complexity that sustain all life and control the distribution of mineral, energy and water resources. Thus understanding these dynamic systems provides the key to sustainable resource usage. The aim of The Earth System Dynamics Network is to facilitate scientific interactions through establishment of an earth and environmental sciences grid that links national and regional data assets with high performance computing through open sourced middleware. The result will be an unparalleled predictive capacity for complex Earth systems. The outcome will be confidence in the knowledge that underpins our decisions as stakeholders to keep Australia sustainable.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100008
Funder
Australian Research Council
Funding Amount
$4,282,859.00
Summary
ARC Training Centre for Behavioural Insights for Technology Adoption (BITA). Australia needs accelerated adoption of innovation technologies to improve outcomes in health, agriculture and cybersecurity. Despite technically viable solutions, innovations fail to be adopted due to behavioural barriers. Behavioural approaches can promote significant gains by bridging the barriers to technology adoption. The Centre for Behavioural Insights for Technology Adoption will boost national productivity by i ....ARC Training Centre for Behavioural Insights for Technology Adoption (BITA). Australia needs accelerated adoption of innovation technologies to improve outcomes in health, agriculture and cybersecurity. Despite technically viable solutions, innovations fail to be adopted due to behavioural barriers. Behavioural approaches can promote significant gains by bridging the barriers to technology adoption. The Centre for Behavioural Insights for Technology Adoption will boost national productivity by identifying, designing and evaluating solutions that address these barriers. By uniting industry and government with world-leading interdisciplinary researchers, the Centre will build transformative capability in people, data and solutions and support Australian organisations to achieve higher returns on technology investment.Read moreRead less
New targets for antiviral therapies. The ability of dangerous viruses to cause lethal disease depends on their capacity to evade the immune system of infected hosts. This project will uncover at the molecular level the strategies used by viruses to disable immune responses; this will identify new ways to treat incurable diseases, by disabling the virus' defences against the immune system.
Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less
Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid i ....Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid in developing and designing artificial tactile sensors inspired by their biological models studied in this project. Long-term, the project is expected to make an original contribution towards developing new technologies and novel medical applications, both of which promise to be of great national benefit.Read moreRead less