Microfluidic Strategy For Circulating Tumour Cells Analysis In Cancer Patients
Funder
National Health and Medical Research Council
Funding Amount
$429,180.00
Summary
My approach and ultimate goal over the next 4 years is to demonstrate the use of recently discovered “Nanoshearing” technology as a standard diagnostic tool for cancer patients undergoing systemic therapy and assess the impact of standard protocols in predicting response to therapy and patient outcomes. Data from this study could potentially define new standards of clinical practice, as they relate to follow-up screening for response to therapy and recurrence of disease.
Modelling The Biology And Transmission Of Influenza Virus - Learning From 1918-19 And Other Outbreaks
Funder
National Health and Medical Research Council
Funding Amount
$114,222.00
Summary
In preparing for a future pandemic of influenza, it is important to learn as much as possible from what happened in the past, particularly from the devastating pandemic of 1918-19. This project will collate detailed information about the spread of influenza in past outbreaks and create a publicly accessible data-base. Mathematical methods will be used to analyse historic and contemporary data, so as to provide better understanding of the spread of influenza, and of the likely effects of social a ....In preparing for a future pandemic of influenza, it is important to learn as much as possible from what happened in the past, particularly from the devastating pandemic of 1918-19. This project will collate detailed information about the spread of influenza in past outbreaks and create a publicly accessible data-base. Mathematical methods will be used to analyse historic and contemporary data, so as to provide better understanding of the spread of influenza, and of the likely effects of social and medical measures for its control. An important theme of the project is to consolidate our knowledge about how past exposure to non-pandemic influenza could provide short-lived protection against any new pandemic, and to explore the implications of this for prevention today. Another theme is to explore the severity of influenza during pandemics, and to identify social and medical factors that might reduce the dose of virus transmitted, or otherwise reduce the severity of infection. The insights from the modeling will also help to identify gaps in knowledge and understanding about the basic biology of influenza, stimulate new research to fill those gaps, and thus offer the prospect of more effective vaccines and treatments for the future control of influenza.Read moreRead less
Deadly Liver Mob: Engaging Aboriginal People In Viral Hepatitis, HIV And Sexual Health Services
Funder
National Health and Medical Research Council
Funding Amount
$848,441.00
Summary
Rates of blood-borne viruses and sexually transmissible infections are high among the Aboriginal and Torres Strait Islander population. A local initiative in western Sydney has trialed a new approach to engagement and care of Aboriginal people. We will implement this approach in services across NSW and evaluate its effectiveness as a sustainable and acceptable model for engaging Aboriginal people in care and develop an implementation plan for future roll-out to other services.
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Developmental Pathways to Intimate Partner Homicide: Understanding Individual and Situational Dimensions. Intimate partner homicide is a serious public health and safety issue. This project will have several benefits. The findings will extend understanding of pathways leading to partner homicide. The findings will contribute to improved decision-making models by police and social welfare agencies. With more valid information about the changing characteristics leading to partner homicide, the fin ....Developmental Pathways to Intimate Partner Homicide: Understanding Individual and Situational Dimensions. Intimate partner homicide is a serious public health and safety issue. This project will have several benefits. The findings will extend understanding of pathways leading to partner homicide. The findings will contribute to improved decision-making models by police and social welfare agencies. With more valid information about the changing characteristics leading to partner homicide, the findings will foster more effective and efficient responses. Additionally, the findings will inform victims of partner violence of risks related to escalation toward fatal outcomes and should facilitate help seeking behaviour. Collectively, project findings should expand understanding, improve service delivery and save lives.
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Understanding and Costing Offending Trajectories: Creating an Evidence-Base for Targeting Crime Prevention. The research will provide an evidence-base for targeting diversionary and crime prevention programs and for assessing their cost-effectiveness. Many of these programs have resulted in a range of beneficial outcomes and they are receiving increased government funding. By providing a better understanding of offending pathways, the research will enable programs to be targeted towards particul ....Understanding and Costing Offending Trajectories: Creating an Evidence-Base for Targeting Crime Prevention. The research will provide an evidence-base for targeting diversionary and crime prevention programs and for assessing their cost-effectiveness. Many of these programs have resulted in a range of beneficial outcomes and they are receiving increased government funding. By providing a better understanding of offending pathways, the research will enable programs to be targeted towards particular at-risk groups at crucial developmental phases. The innovative longitudinal costing method that will be developed and applied in the Queensland context will enable an assessment of the cost-effectiveness of diversionary and crime prevention programs. This will provide a sound empirical basis for directing scarce government resources.Read moreRead less
The Effectiveness Of An Indicated Prevention Program For Anxiety
Funder
National Health and Medical Research Council
Funding Amount
$867,982.00
Summary
Generalised anxiety disorder (GAD) is a common disorder. In this research project, we evaluate the effectiveness of a new automated Internet program which is designed to reduce the risk of GAD and to promote self help. If found to be effective, this website will provide assistance to those at risk living in rural and remote areas without access to other resources, and individuals who prefer to seek help anonymously.
Whistling While They Work: Enhancing the Theory and Practice of Internal Witness Management in Public Sector Organisations. The protection of whistleblowers and other internal witnesses to corruption, misconduct and maladministration is a great unsolved problem in public sector governance. Involving 11 integrity institutions, this first national study of internal witness management will describe and compare organisational experience under varying public interest disclosure regimes across the Au ....Whistling While They Work: Enhancing the Theory and Practice of Internal Witness Management in Public Sector Organisations. The protection of whistleblowers and other internal witnesses to corruption, misconduct and maladministration is a great unsolved problem in public sector governance. Involving 11 integrity institutions, this first national study of internal witness management will describe and compare organisational experience under varying public interest disclosure regimes across the Australian public sector. By identifying and promoting current best practice in workplace responses to public interest whistleblowing, the project will use the experience and perceptions of internal witnesses and first- and second-level managers to identify more routine strategies for preventing, reducing and addressing reprisals and other whistleblowing-related conflicts.Read moreRead less
DNA FINGERPRINTING IN DOCUMENT SECURITY TO COUNTER TERRORISM. Crime costs Australia >$18 billion per year. Of this, money laundering/document fraud is estimated at ~$4.5 billion and ~$1.5 to $3 trillion worldwide. Although many techniques combat document fraud (signatures, specialised inks and paper, watermarking etc) they are severely limited by low specificity or are easy to copy.
Alternatively identification by DNA fingerprinting is highly specific (>10 billion to 1) and can now be obtain ....DNA FINGERPRINTING IN DOCUMENT SECURITY TO COUNTER TERRORISM. Crime costs Australia >$18 billion per year. Of this, money laundering/document fraud is estimated at ~$4.5 billion and ~$1.5 to $3 trillion worldwide. Although many techniques combat document fraud (signatures, specialised inks and paper, watermarking etc) they are severely limited by low specificity or are easy to copy.
Alternatively identification by DNA fingerprinting is highly specific (>10 billion to 1) and can now be obtained from cells embedded within paper. This project will use these techniques to provide definitive document validity and authenticity to minimise document fraud and thus counter illicit finance and terrorist funding.
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Crime and CCTV in Australia: Understanding the Relationship. Crime costs Australia $32 billion annually (Mayhew, 2003). Increased criminal and terrorist activities, internationally and nationally have caused major breaches of security in public places, resulting in heightened investment in crime prevention strategies including Closed Circuit Television (CCTV). However, rigorous research into CCTV's effectiveness on crimes in public places has not been undertaken. This innovative project will ide ....Crime and CCTV in Australia: Understanding the Relationship. Crime costs Australia $32 billion annually (Mayhew, 2003). Increased criminal and terrorist activities, internationally and nationally have caused major breaches of security in public places, resulting in heightened investment in crime prevention strategies including Closed Circuit Television (CCTV). However, rigorous research into CCTV's effectiveness on crimes in public places has not been undertaken. This innovative project will identify CCTV's impact on crime and key socio-legal issues of security of public places. The outcomes will contribute to an important decision-making model for local, state, and federal departments, and private sector organisations responsible for CCTV and related crime prevention technologies. Read moreRead less