The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Cryogenic pipelines to replace trestle for liquefied gas transfer terminals. This project aims to develop geotechnical design tools, software, and publish design guidelines, for engineers to lay and keep cryogenic pipelines stable on the seabed. Transferring liquefied natural gas between floating tankers and onshore plants conventionally relies on a pipeline on a trestle system. As an alternative, novel subsea cryogenic pipelines are being considered. By ensuring the stability of subsea cryogeni ....Cryogenic pipelines to replace trestle for liquefied gas transfer terminals. This project aims to develop geotechnical design tools, software, and publish design guidelines, for engineers to lay and keep cryogenic pipelines stable on the seabed. Transferring liquefied natural gas between floating tankers and onshore plants conventionally relies on a pipeline on a trestle system. As an alternative, novel subsea cryogenic pipelines are being considered. By ensuring the stability of subsea cryogenic pipelines laid directly on the seabed, this project will provide significant benefits to Australia’s liquefied natural gas trade by unlocking substantial cost savings, and making this key export industry more competitive.Read moreRead less
Optimum Multi-rate Filter Bank Design for Speech Enhancement and Communication Systems. Multi-rate signal processing is gaining more and more importance in signal processing applications such as echo cancellation, microphone arrays, speech enhancement and equalisation. This project is aimed at obtaining high performance and high efficiency multi-rate processing designs by developing appropriate problem formulations based on solid mathematical foundations so that powerful optimisation techniques ....Optimum Multi-rate Filter Bank Design for Speech Enhancement and Communication Systems. Multi-rate signal processing is gaining more and more importance in signal processing applications such as echo cancellation, microphone arrays, speech enhancement and equalisation. This project is aimed at obtaining high performance and high efficiency multi-rate processing designs by developing appropriate problem formulations based on solid mathematical foundations so that powerful optimisation techniques can be applied. The developed multi-rate systems will result in low complexity and low power hardware implementations without significant compromise in performance in each application. Size and cost sensitive of communication devices such as personal data assistants, mobile telephones, hands-free devices, and laptops will benefit greatly from the outcome of the project.Read moreRead less
ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the ....ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the core activities of the Network: Researcher Mobility, Workshops and Conferences, Postgraduate Education, and Knowledge Management Systems. The Network is expected to add significant value to pre-existing investments and raise the profile of Australian telecommunications research.Read moreRead less
Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water acro ....Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water across Australia.Read moreRead less
The epidemiology of canine gastrointestinal parasitic zoonoses in different community settings in Thailand. The dog's role in transmitting zoonotic gastrointestinal parasites to humans has been recognised as a significant public health problem worldwide. Surveillance data with regard to canine parasites in Thailand and its regional countries is largely lacking, especially with regard to the dog's role as a perpetuator of the liver and intestinal flukes. This project aims to provide an accurate ....The epidemiology of canine gastrointestinal parasitic zoonoses in different community settings in Thailand. The dog's role in transmitting zoonotic gastrointestinal parasites to humans has been recognised as a significant public health problem worldwide. Surveillance data with regard to canine parasites in Thailand and its regional countries is largely lacking, especially with regard to the dog's role as a perpetuator of the liver and intestinal flukes. This project aims to provide an accurate and comprehensive assessment of the risks these parasites pose to the public using a combination of conventional and novel molecular epidemiological tools. Successful completion of this project will provide a model for control programs to be generated in the SE Asian region.Read moreRead less
Bushfire safety improvements for rural electricity networks using hybrid fault detection incorporating distributed observations of travelling waves. Electrical faults in distribution networks can result in catastrophic bush fires. The existing fault detection methods are known to be incapable of detecting many faults. This project will develop improved protection methods that detect travelling waves produced by dangerous faults such as fallen lines and vegetation contacts.
Risks to human health and the ecosystem from feral pigs in Perth metropolitan water catchments. This project aims to investigate the potential risk feral pigs pose to public health through the dissemination of water borne pathogens within water catchment areas, and to investigate their role in the maintenance and spread of diseases of public and animal health concern in the south west of Western Australia. As well as providing a frontline approach to protecting our water supplies, this project ....Risks to human health and the ecosystem from feral pigs in Perth metropolitan water catchments. This project aims to investigate the potential risk feral pigs pose to public health through the dissemination of water borne pathogens within water catchment areas, and to investigate their role in the maintenance and spread of diseases of public and animal health concern in the south west of Western Australia. As well as providing a frontline approach to protecting our water supplies, this project will also provide valuable data on the nature and extent of the risk feral pigs pose to biodiversity conservation and the environment generally. The outcomes of this research will provide a scientific basis for the development of prioritised strategies for the control of feral pigs in Western Australia.Read moreRead less
Local canons: institutional authority and the category of the literary in Australian secondary-school English syllabuses, 1901-2001. Does literature still have a role to play in contemporary Australian culture and society? Is there any national benefit from the study of Shakespeare? Patrick White? Is literary study irrelevant, and out of touch with contemporary culture? These are contentious and important questions. This research, in seeking a deeper and more detailed understanding of the variab ....Local canons: institutional authority and the category of the literary in Australian secondary-school English syllabuses, 1901-2001. Does literature still have a role to play in contemporary Australian culture and society? Is there any national benefit from the study of Shakespeare? Patrick White? Is literary study irrelevant, and out of touch with contemporary culture? These are contentious and important questions. This research, in seeking a deeper and more detailed understanding of the variability of the category of literature in Australian school education over the past century, promises to make an important contribution to long-standing and still vital national and international debates over the canon: debates that tell us a great deal about our region and the world.Read moreRead less