Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100129
Funder
Australian Research Council
Funding Amount
$425,200.00
Summary
Atomic layer nanofabrication system for multi-functional applications. This project aims to establish a multifunctional atomic layer nanofabrication facility in Sydney with the capacity to provide services nation-wide. The facility has powerful capabilities to produce mono-atom thin films, nanosize powders and two-dimensional nanostructures of a variety of materials, including elemental metals, metal oxides, metal nitrides, metal sulfides, metal-metal compounds, and polymers. This will significa ....Atomic layer nanofabrication system for multi-functional applications. This project aims to establish a multifunctional atomic layer nanofabrication facility in Sydney with the capacity to provide services nation-wide. The facility has powerful capabilities to produce mono-atom thin films, nanosize powders and two-dimensional nanostructures of a variety of materials, including elemental metals, metal oxides, metal nitrides, metal sulfides, metal-metal compounds, and polymers. This will significantly enhance Australian research and industrial activities in the areas of renewable energy production and storage, microelectronics, chemical and bio-sensors, protective coatings, flexible electronic devices, and catalysis.Read moreRead less
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.