Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Visual Analytics for Next Generation Sequencing. Next-generation sequencing technologies have brought a revolution in biology and healthcare, while taxing the ability of scientists and clinicians to identify and process relevant data, to make sense of it all and communicate it to others in a concise and meaningful way. This project aims to tackle this problem through fundamentally new approaches to data selection and visualisation at very large scale, actively encoding for insight into underlyin ....Visual Analytics for Next Generation Sequencing. Next-generation sequencing technologies have brought a revolution in biology and healthcare, while taxing the ability of scientists and clinicians to identify and process relevant data, to make sense of it all and communicate it to others in a concise and meaningful way. This project aims to tackle this problem through fundamentally new approaches to data selection and visualisation at very large scale, actively encoding for insight into underlying biological and biomedical processes, bringing sustainable discovery of new relationships and variations within the data. The project aims to support new approaches to medical diagnosis and treatment, and offer crucial lessons to address the broader challenge of understanding large, complex data sets.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100158
Funder
Australian Research Council
Funding Amount
$348,026.00
Summary
A large-scale distributed experimental facility for the internet of things. This project aims to establish a large-scale, real-world experimental facility for the Internet of Things (IoT), which is currently missing in Australia, as well as in the rest of the world. The project is expected to be an essential instrument to achieve Australia’s leadership on key enabling technologies of the IoT, and to provide Australian research community with a unique platform for large-scale experimentation and ....A large-scale distributed experimental facility for the internet of things. This project aims to establish a large-scale, real-world experimental facility for the Internet of Things (IoT), which is currently missing in Australia, as well as in the rest of the world. The project is expected to be an essential instrument to achieve Australia’s leadership on key enabling technologies of the IoT, and to provide Australian research community with a unique platform for large-scale experimentation and evaluation of IoT technologies and services. The project will also serve as a vehicle for the education and training of Australia’s next generation of scholars and engineers, and contribute to Australia’s scientific visibility.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100131
Funder
Australian Research Council
Funding Amount
$645,000.00
Summary
The AustLit resource: supporting research in studies of Australian literary and narrative cultures. AustLit traces the history of Australia’s engagement with the art of story by creating an innovative web-based environment where all aspects of literary history can be explored, analysed and shared. The 2013 program will broaden AustLit’s information base in areas ranging from contemporary multi-lingual publishing to publishing in the colonial era.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100033
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Australian Acoustic Observatory: A network to monitor biodiversity. This project aims to create a terrestrial acoustic sensor network comprising 450 listening stations across Australia. Acoustic sensing transforms environmental science by recording vocal species 24/7, providing spatial and temporal data for ecosystem monitoring and research. Australia has leading research expertise in this emerging field, which is relevant to its fragile and mega-diverse environment. This project is expected to ....Australian Acoustic Observatory: A network to monitor biodiversity. This project aims to create a terrestrial acoustic sensor network comprising 450 listening stations across Australia. Acoustic sensing transforms environmental science by recording vocal species 24/7, providing spatial and temporal data for ecosystem monitoring and research. Australia has leading research expertise in this emerging field, which is relevant to its fragile and mega-diverse environment. This project is expected to enable and develop continental scale environmental monitoring, and the data generated will be made freely available to all online, enabling new science in understanding ecosystems, long-term environmental change, data visualisation and acoustic science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100049
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Establishment of the Australian data archive: an integrated research facility for the social sciences and humanities. The Australian data archive will enable Australia's leading researchers to address complex social, economic and environmental problems, leading to the development of evidence based policy. The archive will have an open access policy which will ensure that the general public, media and government and non-government agencies are able to examine the data used by researchers to arriv ....Establishment of the Australian data archive: an integrated research facility for the social sciences and humanities. The Australian data archive will enable Australia's leading researchers to address complex social, economic and environmental problems, leading to the development of evidence based policy. The archive will have an open access policy which will ensure that the general public, media and government and non-government agencies are able to examine the data used by researchers to arrive at their conclusions.Read moreRead less