Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Music Usage Metrics and the Future of the Australian Music Industry. This project aims to conduct a comprehensive and systematic examination of changing music consumption patterns in Australia in an era of digital downloads. Based on a comprehensive longitudinal dataset on music use in Australia provided by industry partners, the project plans to use innovative computational methods to develop and test evidence-based models for generating, sharing and distributing music revenues. It also plans t ....Music Usage Metrics and the Future of the Australian Music Industry. This project aims to conduct a comprehensive and systematic examination of changing music consumption patterns in Australia in an era of digital downloads. Based on a comprehensive longitudinal dataset on music use in Australia provided by industry partners, the project plans to use innovative computational methods to develop and test evidence-based models for generating, sharing and distributing music revenues. It also plans to examine the current and future uses of music usage data in decision-making processes in music organisations, as well as the potential consequences of such use for practitioners and industry stakeholders. The project aims to support the future growth of the Australian music industry.Read moreRead less
Low-cost Sensing Methods and Hybrid Learning Models. This project aims to revolutionise the theory and practice of sensing and monitoring by developing novel Artificial Intelligence and Internet of Things technologies. This project expects to generate new knowledge in the area of Artificial Intelligence of Things by combining sensing, machine learning, and big data analytics. Expected outcomes of this project include novel low-cost sensing methods and new hybrid machine learning models for predi ....Low-cost Sensing Methods and Hybrid Learning Models. This project aims to revolutionise the theory and practice of sensing and monitoring by developing novel Artificial Intelligence and Internet of Things technologies. This project expects to generate new knowledge in the area of Artificial Intelligence of Things by combining sensing, machine learning, and big data analytics. Expected outcomes of this project include novel low-cost sensing methods and new hybrid machine learning models for predictive sensory data analytics. This should provide significant benefits, such as substantially reduced operating and service costs and improved accuracy for real-time monitoring in the fields where cheap-to-implement and easy-to-service monitoring systems over large geographical areas are imperative.Read moreRead less
Taming the uncertainty in trajectory data. This project aims to develop effective and efficient methods to manage large scale uncertain trajectory data. It provides individuals, business, government and social groups the ability to explore significant uncertain trajectories and their patterns, for important usages in location based services, logistic, transportation and tourism.
Bio-Acoustic Observatory: Engaging Birdwatchers to Monitor Biodiversity by Collaboratively Collecting and Analysing Big Audio Data. This project will research how to crowd-source the collection and analysis of environmental animal sounds (for example, birds, frogs). This will enable a bio-acoustic observatory which provides a scalable, objective and permanent record of the environment, something hitherto impossible. The project will investigate how to engage the community of birdwatchers to exte ....Bio-Acoustic Observatory: Engaging Birdwatchers to Monitor Biodiversity by Collaboratively Collecting and Analysing Big Audio Data. This project will research how to crowd-source the collection and analysis of environmental animal sounds (for example, birds, frogs). This will enable a bio-acoustic observatory which provides a scalable, objective and permanent record of the environment, something hitherto impossible. The project will investigate how to engage the community of birdwatchers to extend their pastime online with new kinds of interactive tools to enable collaborative analysis of big audio data, and new kinds of birding experiences. Outcomes will be: new approaches to physical/virtual engagement in human-computer interaction; new approaches to analysing big data; a new validated ecological monitoring technique and concepts for sustainable knowledge generation communities.Read moreRead less
Visual Analytics for Next Generation Sequencing. Next-generation sequencing technologies have brought a revolution in biology and healthcare, while taxing the ability of scientists and clinicians to identify and process relevant data, to make sense of it all and communicate it to others in a concise and meaningful way. This project aims to tackle this problem through fundamentally new approaches to data selection and visualisation at very large scale, actively encoding for insight into underlyin ....Visual Analytics for Next Generation Sequencing. Next-generation sequencing technologies have brought a revolution in biology and healthcare, while taxing the ability of scientists and clinicians to identify and process relevant data, to make sense of it all and communicate it to others in a concise and meaningful way. This project aims to tackle this problem through fundamentally new approaches to data selection and visualisation at very large scale, actively encoding for insight into underlying biological and biomedical processes, bringing sustainable discovery of new relationships and variations within the data. The project aims to support new approaches to medical diagnosis and treatment, and offer crucial lessons to address the broader challenge of understanding large, complex data sets.Read moreRead less