Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100950
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Building intelligence into online video services by learning user interests. This project aims to build an intelligent video streaming service by characterising users’ view interest patterns and predict user interest changes through learning data from Internet to address the challenge caused by astronomic video population. The outcomes of the project will be of great values for users and our society by intelligently filtering out valueless, harmful, illegal and unwanted videos in advance.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100158
Funder
Australian Research Council
Funding Amount
$348,026.00
Summary
A large-scale distributed experimental facility for the internet of things. This project aims to establish a large-scale, real-world experimental facility for the Internet of Things (IoT), which is currently missing in Australia, as well as in the rest of the world. The project is expected to be an essential instrument to achieve Australia’s leadership on key enabling technologies of the IoT, and to provide Australian research community with a unique platform for large-scale experimentation and ....A large-scale distributed experimental facility for the internet of things. This project aims to establish a large-scale, real-world experimental facility for the Internet of Things (IoT), which is currently missing in Australia, as well as in the rest of the world. The project is expected to be an essential instrument to achieve Australia’s leadership on key enabling technologies of the IoT, and to provide Australian research community with a unique platform for large-scale experimentation and evaluation of IoT technologies and services. The project will also serve as a vehicle for the education and training of Australia’s next generation of scholars and engineers, and contribute to Australia’s scientific visibility.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100131
Funder
Australian Research Council
Funding Amount
$645,000.00
Summary
The AustLit resource: supporting research in studies of Australian literary and narrative cultures. AustLit traces the history of Australia’s engagement with the art of story by creating an innovative web-based environment where all aspects of literary history can be explored, analysed and shared. The 2013 program will broaden AustLit’s information base in areas ranging from contemporary multi-lingual publishing to publishing in the colonial era.
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.
Improving student outcomes: coaching teachers in the power of feedback. This project aims to investigate how student outcomes can be augmented through coaching teachers in effective feedback practice. The project addresses a critical problem of stagnating levels of student achievement in Australian schools with the innovative research design combining evidence-based, pedagogies of feedback, formative assessment and instructional coaching to improve teacher practice and ultimately raise student a ....Improving student outcomes: coaching teachers in the power of feedback. This project aims to investigate how student outcomes can be augmented through coaching teachers in effective feedback practice. The project addresses a critical problem of stagnating levels of student achievement in Australian schools with the innovative research design combining evidence-based, pedagogies of feedback, formative assessment and instructional coaching to improve teacher practice and ultimately raise student achievement levels. The project aims to guide policy implementation in pedagogy to raise the quality of teaching standards and to improve learning outcomes for Australian students. Ultimately, outcomes from the research will help close the gap for low achieving students, and challenge and extend those who may already be meeting required benchmarks. Read moreRead less
Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This pr ....Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This project plans to identify teacher behaviours that motivate students in their first year at secondary school. Using an experimental design with a representative sample of 150 teachers and 1500 students in low socioeconomic areas across three states, the project plans to test whether an online professional learning program for teachers can improve student engagement and achievement. This cost-effective and scalable intervention is designed for widespread dissemination to Australian teachers.Read moreRead less
Increasing the rural medical workforce: investigating personal traits to enhance our understanding and improve training of rural registrars. This project will research new methodologies for increasing the number of rural doctors in Australia. A better understanding of those individuals best suited for rural practice will provide value for money to the Government by making the most efficient use of initiatives to increase recruitment and retention of the rural workforce.
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Building sound ecological restoration strategies for endangered amphibians. This project integrates the principles of ecology and restoration ecology to secure the persistence of a population of an endangered frog in the context of a large urban renewal and ecological rehabilitation precinct at the Sydney Olympic Park. Habitat rehabilitation at the site provides an unrivalled opportunity for ecology to provide robust scientific direction and support for conservation management practices and deve ....Building sound ecological restoration strategies for endangered amphibians. This project integrates the principles of ecology and restoration ecology to secure the persistence of a population of an endangered frog in the context of a large urban renewal and ecological rehabilitation precinct at the Sydney Olympic Park. Habitat rehabilitation at the site provides an unrivalled opportunity for ecology to provide robust scientific direction and support for conservation management practices and develops the site as a model site illustrating adaptive management practices. The project investigates the role of two threatening processes in amphibian decline in a habitat management context and the outcomes have wide implications for the global amphibian decline. Read moreRead less